Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry /

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолч: Peters, Sheila Annie
Байгууллагын зохиогч: ebrary, Inc
Формат: Цахим Цахим ном
Хэл сонгох:англи
Хэвлэсэн: Hoboken, N.J. : Wiley, c2011.
Нөхцлүүд:
Онлайн хандалт:An electronic book accessible through the World Wide Web; click to view
Шошгууд: Шошго нэмэх
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
Агуулга:
  • Modelling in the pharmaceutical industry
  • Physiologically-based modelling
  • A review of pharmacokinetic principles
  • Physiological model for absorption
  • Physiological model for distribution
  • Physiological models for drug metabolism and excretion
  • Generic whole-body physiologically-based pharmacokinetic modelling
  • Variability, uncertainty and sensitivity analysis
  • Evaluation of drug-drug interaction risk with pbpk models
  • PBPK of biotherapeutics
  • Data integration and sensitivity analysis
  • Hypothesis generation and pharmacokinetic predictions
  • Integration of PBPK and pharmacodynamics
  • PBPK modelling of populations
  • PBPK models along the drug discovery and development value chain.