Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry /
Enregistré dans:
| Auteur principal: | |
|---|---|
| Collectivité auteur: | |
| Format: | Électronique eBook |
| Langue: | anglais |
| Publié: |
Hoboken, N.J. :
Wiley,
c2011.
|
| Sujets: | |
| Accès en ligne: | An electronic book accessible through the World Wide Web; click to view |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|
Table des matières:
- Modelling in the pharmaceutical industry
- Physiologically-based modelling
- A review of pharmacokinetic principles
- Physiological model for absorption
- Physiological model for distribution
- Physiological models for drug metabolism and excretion
- Generic whole-body physiologically-based pharmacokinetic modelling
- Variability, uncertainty and sensitivity analysis
- Evaluation of drug-drug interaction risk with pbpk models
- PBPK of biotherapeutics
- Data integration and sensitivity analysis
- Hypothesis generation and pharmacokinetic predictions
- Integration of PBPK and pharmacodynamics
- PBPK modelling of populations
- PBPK models along the drug discovery and development value chain.