Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry /

Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry /

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Bibliographic Details
Main Author: Peters, Sheila Annie
Corporate Author: ebrary, Inc
Format: Electronic eBook
Language:English
Published: Hoboken, N.J. : Wiley, c2011.
Subjects:
Pharmacokinetics > Mathematical models.
Drugs > Design > Mathematical models.
Electronic books.
Online Access:An electronic book accessible through the World Wide Web; click to view
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Table of Contents:
  • Modelling in the pharmaceutical industry
  • Physiologically-based modelling
  • A review of pharmacokinetic principles
  • Physiological model for absorption
  • Physiological model for distribution
  • Physiological models for drug metabolism and excretion
  • Generic whole-body physiologically-based pharmacokinetic modelling
  • Variability, uncertainty and sensitivity analysis
  • Evaluation of drug-drug interaction risk with pbpk models
  • PBPK of biotherapeutics
  • Data integration and sensitivity analysis
  • Hypothesis generation and pharmacokinetic predictions
  • Integration of PBPK and pharmacodynamics
  • PBPK modelling of populations
  • PBPK models along the drug discovery and development value chain.

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