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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by chan...

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Главные авторы: Tveito, Aslak (Автор), Lines, Glenn T. (Автор)
Соавтор: SpringerLink (Online service)
Формат: Электронный ресурс eКнига
Язык:английский
Опубликовано: Cham : Springer International Publishing : Imprint: Springer, 2016.
Серии:Lecture Notes in Computational Science and Engineering, 111
Предметы:
Mathematics.
Computer graphics.
Computer mathematics.
Computational Science and Engineering.
Biomedicine general.
Computer Imaging, Vision, Pattern Recognition and Graphics.
Online-ссылка:http://dx.doi.org/10.1007/978-3-319-30030-6
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Оглавление:
  • Preface
  • Background: Contents and Method
  • One-dimensional calcium release
  • Models of open and state blockers
  • Two-dimensional calcium release
  • Computing theoretical drugs in the two-dimensional case
  • Generalized systems
  • Calcium-induced calcium release
  • Numerical release for CICR
  • A prototypical model of an ion channel
  • Inactivated ion channels
  • A simple model of the sodium channel
  • Mutations affecting the mean open time
  • The burst mode
  • Whole sale action potentials
  • .

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