Applications of toxicogenomics in safety evaluation and risk assessment

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Bibliographic Details
Corporate Author: ebrary, Inc
Other Authors: Boverhof, Darrell R., Gollapudi, B. Bhaskar
Format: Electronic eBook
Language:English
Published: Hoboken, N.J. : John Wiley & Sons, c2011.
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Online Access:An electronic book accessible through the World Wide Web; click to view
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Table of Contents:
  • Toxicology, "omics" technologies, and toxicogenomics : a primer
  • Introduction to human health risk assessment
  • Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward
  • Approaches and practical considerations for the analysis of toxicogenomics data
  • Genomics in identifying mutagenic mode of action in carcinogenesis
  • Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens
  • Genomics in characterizing endocrine toxicity
  • Studying organ specific toxicity using gene expression profiling
  • Toxicogenomic studies in human populations
  • Toxicogenomics applied to ecological risk assessment
  • Analysis of transcriptomic dose response data for toxicology and risk assessment
  • Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges
  • Toxicogenomics and animal alternatives
  • Toxicogenomics and the regulatory framework
  • Standardization of gene expression information for the safety evaluation--activities in Japan -
  • Applying transcriptional profiling in drug safety evaluation
  • Reframing the risk assessment paradigm : towards a systems biology approach.