Biopharmaceutics modeling and simulations theory, practice, methods, and applications /
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| Format: | Électronique eBook |
| Langue: | anglais |
| Publié: |
Hoboken, N.J. :
Wiley,
c2012.
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| Sujets: | |
| Accès en ligne: | An electronic book accessible through the World Wide Web; click to view |
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Table des matières:
- Introduction
- Theoretical framework I : solubility
- Theoretical framework II : dissolution
- Theoretical framework III : biological membrane permeation
- Theoretical framework IV : gastrointestinal transit models and integration
- Physiology of gastrointestinal tract and other administration sites in humans and animals
- Drug parameters
- Validation of mechanistic models
- Bioequivalence and biopharmaceutical classification system
- Dose and particle size dependency
- Enabling formulations
- Food effect
- Biopharmaceutical modeling for miscellaneous cases
- Intestinal transporters
- Strategy in drug discovery and development
- Epistemology of biopharmaceutical modeling and good simulation practice.