Biopharmaceutics modeling and simulations theory, practice, methods, and applications /

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Hlavní autor: Sugano, Kiyohiko
Korporativní autor: ebrary, Inc
Médium: Elektronický zdroj E-kniha
Jazyk:angličtina
Vydáno: Hoboken, N.J. : Wiley, c2012.
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Obsah:
  • Introduction
  • Theoretical framework I : solubility
  • Theoretical framework II : dissolution
  • Theoretical framework III : biological membrane permeation
  • Theoretical framework IV : gastrointestinal transit models and integration
  • Physiology of gastrointestinal tract and other administration sites in humans and animals
  • Drug parameters
  • Validation of mechanistic models
  • Bioequivalence and biopharmaceutical classification system
  • Dose and particle size dependency
  • Enabling formulations
  • Food effect
  • Biopharmaceutical modeling for miscellaneous cases
  • Intestinal transporters
  • Strategy in drug discovery and development
  • Epistemology of biopharmaceutical modeling and good simulation practice.