Drug repositioning bringing new life to shelved assets and existing drugs /
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| Další autoři: | , |
| Médium: | Elektronický zdroj E-kniha |
| Jazyk: | angličtina |
| Vydáno: |
Hoboken :
John Wiley & Sons,
c2012.
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| Témata: | |
| On-line přístup: | An electronic book accessible through the World Wide Web; click to view |
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Obsah:
- Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison
- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt
- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller
- Regulatory considerations and strategies for drug repositioning / Ken Phelps
- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb
- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.]
- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.]
- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee
- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume
- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.]
- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong
- Drug repositioning efforts by non-profit foundations
- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark
- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.