Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry /
Bewaard in:
| Hoofdauteur: | |
|---|---|
| Coauteur: | |
| Formaat: | Elektronisch E-boek |
| Taal: | Engels |
| Gepubliceerd in: |
Hoboken, N.J. :
Wiley,
c2011.
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| Onderwerpen: | |
| Online toegang: | An electronic book accessible through the World Wide Web; click to view |
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Inhoudsopgave:
- Modelling in the pharmaceutical industry
- Physiologically-based modelling
- A review of pharmacokinetic principles
- Physiological model for absorption
- Physiological model for distribution
- Physiological models for drug metabolism and excretion
- Generic whole-body physiologically-based pharmacokinetic modelling
- Variability, uncertainty and sensitivity analysis
- Evaluation of drug-drug interaction risk with pbpk models
- PBPK of biotherapeutics
- Data integration and sensitivity analysis
- Hypothesis generation and pharmacokinetic predictions
- Integration of PBPK and pharmacodynamics
- PBPK modelling of populations
- PBPK models along the drug discovery and development value chain.