Integrated cardiac safety assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance /

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Bibliographische Detailangaben
1. Verfasser: Turner, J. Rick
Körperschaft: ebrary, Inc
Weitere Verfasser: Durham, Todd A.
Format: Elektronisch E-Book
Sprache:Englisch
Veröffentlicht: Hoboken, N.J. : John Wiley & Sons, c2009.
Schlagworte:
Online-Zugang:An electronic book accessible through the World Wide Web; click to view
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Inhaltsangabe:
  • The importance of cardiac safety assessments
  • The biological basis of adverse drug reactions
  • Cardiac structure and function
  • Cardiac pathophysiology and disease
  • Drug discovery and drug design
  • Nonclinical development
  • The thorough QT/QTc trial
  • General safety assessments
  • Therapeutic use trials and meta-analyses
  • Assessment methodologies in nonexperimental postmarketing surveillance
  • Postmarketing proarrhythmic cardiac safety assessments
  • Generalized cardiac safety
  • Medication errors, adherence, and concordance
  • Future directions in drug safety.