Foundations of comparative genomics

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Detalhes bibliográficos
Autor principal: Mushegian, Arcady R.
Autor Corporativo: ebrary, Inc
Formato: Recurso Electrónico livro electrónico
Idioma:inglês
Publicado em: Amsterdam ; Boston : Academic Press, c2007.
Assuntos:
Acesso em linha:An electronic book accessible through the World Wide Web; click to view
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Sumário:
  • The beginning of computational genomics
  • Finding sequence similarities
  • Homology: can we get it right?
  • Getting ready for the era of comparative genomics: the importance of viruses
  • The first fact of comparative genomics: protein sequences are remarkably resilient in evolution
  • The second fact of comparative genomics: functional convergence at the molecular level
  • Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches
  • Prediction of function and reconstruction of metabolism: post-homology approaches
  • Structural genomics: what does it tell us about life?
  • How many protein families are there?
  • Phylogenetic inference and the era of complete genomes
  • Two stories about evolution
  • Minimal and ancestral genomes
  • Comparative genomics and systems biology.