Search Results - muleta~

Polypharmacology in drug discovery

Table of Contents: “…Silver 9.1 Introduction. 9.2 Classical antibacterial polypharmacology. 9.3 New approaches to multi-targeted single pharmacophores. 9.4 Synthetic lethals. 9.5 Hybrid molecules. 9.6 Conclusions. 10 A "magic shotgun" perspective on anticonvulsant mechanisms Matt T. …”
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Sleep in childhood neurological disorders

Table of Contents: “…Sheldon -- Craniofacial disorders and sleep / Tarig Ali-Dinar and Nalton F. Ferraro -- Multi-disciplinary team approach for the evaluation of children with sleep disorders / Umakanth Khatwa ... …”
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Engineering principles of combat modeling and distributed simulation

Table of Contents: “…Sorroche -- Standards-based combat simulation initialization using the military scenario definition language (MSDL) / R.L. Wittman -- Multi-resolution combat modeling / M.D. Petty, R.W. …”
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Proceedings of the International Conference on Social Modeling and Simulation, plus Econophysics Colloquium 2014

Table of Contents: “…-Chapter 3 Interaction and Distribution -- Geographic Dependency of Population Distribution- Spatiotemporal Analysis of Influenza Epidemics in Japan -- A Universal Lifetime Distribution for Multi-Species Systems -- Firm Age Distributions and the Decay Rate of Firm Activities -- Empirical Analysis of Firm-Dynamics on Japanese Inter-firm trade Network -- Direct participants’ behavior through the lens of transactional analysis: the case of SPEI -- Chapter 4 Traffic and Pedestrian -- Pedestrian Dynamics in Jamology -- Qualitative Methods of Validating Evacuation Behaviors -- Collective dynamics of pedestrians with no fixed destination -- Traffic Simulation of Kobe-city -- MOSAIIC: city-level agent-based traffic simulation adapted to emergency situations -- GUI for Agent Based Modeling -- Chapter 5 Social Media -- Emotional Changes in Japanese Blog Space Resulting from the 3.11 Earthquake -- Modeling of ENJYO via process of consensus formation on SNS -- A network structure of emotional interactions in an electronic bulletin board -- Scale-free network topologies with clustering similar to online social networks -- Identifying Colors of Products and Associated Personalized Recommendation Engine in e-Fashion Business.…”
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Neurotransmitters in plants : perspectives and applications /

Table of Contents: “…Chapter 4: Melatonin and Serotonin in Plant Morphogenesis and DevelopmentChapter 5: The Multi-Regulatory Properties of Melatonin in Plants; Chapter 6: Serotonin and Melatonin in Root Morphogenesis: Functions and Mechanisms; Chapter 7: Acetylcholine as a Regulator of Differentiation and Development in Tomato; SECTION III: Cellular Location of Neurotransmitters: Their Reception and Signaling; Chapter 8: Tools for Microanalysis of the Neurotransmitter Location in Plant Cells; Chapter 9: Inter- and Intracellular Signaling in Plant Cells with Participation of Neurotransmitters (Biomediators)…”
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Intersectionality and difference in childhood and youth : global perpsectives /

Table of Contents: “…Subverting neighbourhood normalcy and the impacts on child wellbeing in Malta; Chapter summary; Introduction; Methodology; Findings: how children's wellbeing may differ according to the neighbourhood social processes and contextual norms in relation to their parents' marital status.; Conclusion; References…”
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Competition policy and patent law under uncertainty regulating innovation /

Table of Contents: “…Favoring dynamic over static competition: implications for antitrust analysis and policy David Teece; 7. Antitrust, multi-dimensional competition, and innovation: do we have an antitrust-relevant theory of competition now? …”
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Mixed models theory and applications with R / by Demidenko, Eugene, 1948-

Table of Contents: “…331.16 Software and books361.17 Summary points 372 MLE for LME Model 412.1 Example: Weight versus height 422.2 The model and log-likelihood functions 452.3 Balanced random-coefficient model 602.4 LME model with random intercepts 642.5 Criterion for the MLE existence 722.6 Criterion for positive definiteness of matrix D742.7 Preestimation bounds for variance parameters 772.8 Maximization algorithms792.9 Derivatives of the log-likelihood function 812.10 Newton--Raphson algorithm 832.11 Fisher scoring algorithm852.12 EM algorithm 882.13 Starting point 932.14 Algorithms for restricted MLE 962.15 Optimization on nonnegative definite matrices 972.16 lmeFS and lme in R 1082.17 Appendix: Proof of the MLE existence 1122.18 Summary points 1153 Statistical Properties of the LME Model 1193.1 Introduction 1193.2 Identifiability of the LMEmodel 1193.3 Information matrix for variance parameters 1223.4 Profile-likelihood confidence intervals 1333.5 Statistical testing of the presence of random effects 1353.6 Statistical properties of MLE 1393.7 Estimation of random effects 1483.8 Hypothesis and membership testing 1533.9 Ignoring random effects 1573.10 MINQUE for variance parameters 1603.11 Method of moments 1693.12 Variance least squares estimator 1733.13 Projection on D+ space 1783.14 Comparison of the variance parameter estimation 1783.15 Asymptotically efficient estimation for [beta] 1823.16 Summary points 1834 Growth Curve Model and Generalizations 1874.1 Linear growth curve model 1874.2 General linear growth curve model 2034.3 Linear model with linear covariance structure 2214.4 Robust linear mixed effects model 2354.5 Appendix: Derivation of the MM estimator 2434.6 Summary points 2445 Meta-analysis Model 2475.1 Simple meta-analysis model 2485.2 Meta-analysis model with covariates 2755.3 Multivariate meta-analysis model 2805.4 Summary points 2916 Nonlinear Marginal Model 2936.1 Fixed matrix of random effects 2946.2 Varied matrix of random effects 3076.3 Three types of nonlinear marginal models 3186.4 Total generalized estimating equations approach 3236.5 Summary points 3307 Generalized Linear Mixed Models 3337.1 Regression models for binary data 3347.2 Binary model with subject-specific intercept 3577.3 Logistic regression with random intercept 3647.4 Probit model with random intercept 3847.5 Poisson model with random intercept 3887.6 Random intercept model: overview 4037.7 Mixed models with multiple random effects 4047.8 GLMM and simulation methods 4137.9 GEE for clustered marginal GLM 4187.10 Criteria for MLE existence for binary model 4267.11 Summary points 4318 Nonlinear Mixed Effects Model 4358.1 Introduction 4358.2 The model 4368.3 Example: Height of girls and boys 4398.4 Maximum likelihood estimation 4418.5 Two-stage estimator 4448.6 First-order approximation 4508.7 Lindstrom--Bates estimator 4528.8 Likelihood approximations 4578.9 One-parameter exponential model 4608.10 Asymptotic equivalence of the TS and LB estimators 4678.11 Bias-corrected two-stage estimator 4698.12 Distribution misspecification 4718.13 Partially nonlinear marginal mixed model 4748.14 Fixed sample likelihood approach4758.15 Estimation of random effects and hypothesis testing 4788.16 Example (continued) 4798.17 Practical recommendations 4818.18 Appendix: Proof of theorem on equivalence 4828.19 Summary points 4859 Diagnostics and Influence Analysis 4899.1 Introduction 4899.2 Influence analysis for linear regression 4909.3 The idea of infinitesimal influence 4939.4 Linear regression model 4959.5 Nonlinear regression model 5129.6 Logistic regression for binary outcome 5179.7 Influence of correlation structure 5269.8 Influence of measurement error 5279.9 Influence analysis for the LME model 5309.10 Appendix: MLE derivative with respect to σ2 5369.11 Summary points 53710 Tumor Regrowth Curves 54110.1 Survival curves 54310.2 Double--exponential regrowth curve 54510.3 Exponential growth with fixed regrowth time 55910.4 General regrowth curve 56510.5 Double--exponential transient regrowth curve 56610.6 Gompertz transient regrowth curve 57310.7 Summary points 57611 Statistical Analysis of Shape 57911.1 Introduction 57911.2 Statistical analysis of random triangles 58111.3 Face recognition 58411.4 Scale-irrelevant shape model 58511.5 Gorilla vertebrae analysis 58911.6 Procrustes estimation of the mean shape 59111.7 Fourier descriptor analysis 59811.8 Summary points 60712 Statistical Image Analysis 60912.1 Introduction 60912.2 Testing for uniform lighting 61212.3 Kolmogorov--Smirnov image comparison 61612.4 Multinomial statistical model for images 62012.5 Image entropy 62312.6 Ensemble of unstructured images 62712.7 Image alignment and registration 64012.8 Ensemble of structured images 65212.9 Modeling spatial correlation 65412.10 Summary points 66013 Appendix: Useful Facts and Formulas 66313.1 Basic facts of asymptotic theory 66313.2 Some formulas of matrix algebra 67013.3 Basic facts of optimization theory 674References 683Index 713.…”
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Rethinking culture, organization and management /

Table of Contents: “…Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Table of Contents -- Series note -- List of contributors -- Chapter 1 Introduction: rethinking culture, organization and management -- Chapter 2 Joanne Martin -- (Meta)theory of culture -- 'Other' writings -- Gender inequality -- On (gendered) aspects of academic careers and research processes -- Conclusion -- the future of Martin and organization studies -- Acknowledgement -- Notes -- Recommended reading -- References -- Chapter 3 Mary Douglas: the cultural and material manifestations of dirt and dirty work…”
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Adoption and impact of OER in the Global South /

Table of Contents: “…Factors influencing open educational practices and OER in the global south : meta-synthesis of the ROER4D project -- 3. OER use in the global south : a baseline survey of higher education instructors -- section 2. …”
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Bayesian cost-effectiveness analysis of medical treatments / by Moreno, Elías, Vázquez Polo, Francisco José, Negrín-Hernández, Miguel Angel

Table of Contents: “…Optimal treatments </LI><P></P></B><P>Introduction </P><P>The net benefit of a treatment </P><P>Utility functions of the net benefit </P><P>The utility function U Optimal treatments </P><P>Interpretation of the expected utility </P><P>The utility function U Optimal treatments </P><P>Interpretation of the expected utility </P><P>Penalizing a new treatment </P><P>Parametric classes of probabilistic rewards </P><P>Frequentist predictive distribution of the net bene</P><P>Bayesian predictive distribution of the net benefit </P><P>Statistical models for cost and effectiveness </P><P>The normal-normal model </P><P>The lognormal-normal model </P><P>The lognormal-Bernoulli model </P><P>The bivariate normal model </P><P>The dependent lognormal-Bernoulli model </P><P>A case study </P><P>The cost-effectiveness acceptability curve for the utility</P><P>function U </P><P>The case of completely unknown rewards </P><P>The case of parametric rewards </P><P>The cost-effectiveness acceptability curve for the utility</P><P>function U </P><P>Comments on cost-effectiveness acceptability curve </P><P></P><B><P><LI>Cost-effectiveness analysis for heterogenous data </LI><P></P></B><P>Introduction </P><P>Clustering </P><P>Prior distributions </P><P>Posterior distribution of the cluster models </P><P>Examples </P><P>Bayesian meta-analysis </P><P>The Bayesian meta-model </P><P>The likelihood of the meta-parameter and the</P><P>linking distribution </P><P>Properties of the linking distribution </P><P>Examples </P><P>Contents</P><P>The predictive distribution of (c; e) conditional on a partition</P><P>The unconditional predictive distribution of (c; e) </P><P>The predictive distribution of the net benefit z </P><P>The case of independent c and e </P><P>Optimal treatments </P><P>Examples </P><P></P><B><P><LI>Subgroup cost-effectiveness</B> <B>analysis </LI><P></P></OL></B><P>Introduction </P><P>The data and the Bayesian model </P><P>The independent normal-normal model </P><P>The normal-normal model </P><P>The lognormal-normal model </P><P>The probit sampling model </P><P>Bayesian variable selection </P><P>Notation </P><P>Posterior model probability </P><P>The hierarchical uniform prior for models </P><P>Zellner's gpriors for model parameters </P><P>Intrinsic priors for model parameters </P><P>Bayes factors for normal linear models </P><P>Bayes factors for probit models </P><P>Bayesian predictive distribution of the net benefit </P><P>The normal-normal case </P><P>The case where c and e are independent </P><P>The lognormal-normal case </P><P>Optimal treatments for subgroups </P><P>Examples </P><P>Improving subgroup definition </P><P></P>…”
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Los refugiados españoles y la cultura mexicana : actas de las segundas jornadas celebradas en El Colegio de México en noviembre de 1996 /

Table of Contents: “…Luis Cernuda ante la poesía española peninsular (1957-1962) / James Valender -- La experiencia mexicana de Juan Gil-Albert / Rose Corral -- Emilio Prados: el sentido en la ausencia / Juan Manuel Díaz de Guereñu -- Poetas hispanoamericanos: algunos aspectos como ensayistas (Ramón Xirau, Manuel Durán, Tomás Segovia) / Arturo Souto Albarce -- Un boceto del paisaje: Acevedo, Toussaint y Moreno Villa / Hector Perea -- Jose Moreno Villa y la "ecuela mexicana" / Juan Perez de Ayala -- Un Buñuel de ida y vuelta / Agustín Sánchez Vidal -- El hombre Ramón y otros papeles (notas sobre un expediente) / Andres Lira -- Los filósofos del exilio: Jose Gaos / Teresa Rodríguez de Lecea -- Ortega y el hiperión mexicano / Francisco Gil Villegas M. -- Los científicos y los órganos de ayuda a los refugiados / Luis Alfredo Baratas Díaz --Seneca por ejemplo: una casa para la resistencia, 1939-1947 / Víctor Díaz Arciniega -- Miguel Prieto, entre impresores y tipógrafos / Martí Soler -- Rescatar una memoria: un proyecto para la recuperación de fondos bibliográficos y documentales del exilio español en Mexico / Jose García-Velasco -- La revista Las Españas, cincuenta años despues / Ascención Hernández de León-Portilla -- Dulcinea en el exilio / Angelina Muñiz Huberman -- Mexico y las instituciones de la república española en el exilio / Alicia Alted Vigil -- Alfonso Reyes, diplomático en España: años cómodos, pero insatisfactorios / Javier Garciadiego Dantan -- Perfiles del exilio: dos refugiadas / Jose Antonio Matesanz -- Narciso Bassols en la trinchera pública: su lucha a favor de la España Republicana y contra el fascismo / Georgina Naufal Tuena -- Refugiados españoles en Mexico: recuento y caracterizaciõn / Dolores Pla Brugat -- La Unión de Profesores Universitarios Españoles en el exilio: motivos y razones / Concepción Ruiz-Funes -- El asilo político en Mexico: las fuentes del diálogo / Fernando Serrano Migallón -- Naturalistas en el exilio: Nueva España en el Nuevo Mundo? …”
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Situating portfolios four perspectives /

Table of Contents: “…Williamson -- Kentucky's state-mandated writing portfolios and teacher accountability / Susan Callahan -- Teachers and students : reclaiming assessment via portfolios / Sandra Murphy -- Establishing sound portfolio practice : reflections on faculty development / Cheryl Evans Ause and Gerilee Nicastro -- Of large-mouth milk jugs, cosmic trash compactors, and renewal machines : reflections on a multi-task portfolio assessment / Charlotte W. O'Brien -- Portfolio for doctoral candidacy : a veritable alternative / Janice M. …”
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Understanding Society and Natural Resources Forging New Strands of Integration Across the Social Sciences /

Table of Contents: “…Gowdy -- Chapter 7: The Humanities as Hypotheses for Understanding Resource Challenges and Conflicts: Bron Taylor -- Part 2: Topics in Integration: Chapter 8: Innovative Multi-level Approaches to Risk Governance Research: Armin Haas, Peijun Shi, Qian Ye -- Chapter 9: Livelihoods, Poverty, and Conservation : Lucca Tacconi, Andrew Vayda -- Chapter 10: Who’s afraid of Thomas Malthus?…”
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Managing Elevated Risk Global Liquidity, Capital Flows, and Macroprudential Policy—An Asian Perspective / by Azis, Iwan J., Shin, Hyun Song

Table of Contents: “…Contents -- Foreword -- Chapter 1: Introduction and Overview -- Chapter 2: The Three Phases of Global Liquidity -- 2.1: Conceptual and Measurement Issues -- 2.2: First Phase of Global Liquidity -- 2.2.1: Round-trip Bank Flows to the US -- 2.2.2: Banking Sector Flows to the Rest of the World -- 2.2.3: Exchange Rates and Leverage -- 2.3: Second Phase of Global Liquidity -- 2.4: The Case of Emerging Asia -- 2.5: Third Phase and Onward -- 2.6: References -- Chapter 3: Early Warning Indicators for Financial Vulnerabilities -- 3.1: Principles for Selection of Early Warning Indicators -- 3.2: Core and Noncore Liabilities -- 3.3: References -- Chapter 4: Emerging Asia’s Noncore Liabilities and Policy Effectiveness -- 4.1: Bank-led Flows, Noncore Liabilities, and Credit Growth -- 4.2: Reassessing Monetary Policy -- 4.3: Appendix -- 4.4: References -- Chapter 5: Capital Flows and Income Distribution -- 5.1: National Policy Remains Key -- 5.2: How Capital Flows Affect Income Inequality -- 5.3: Prioritization for a Multi-Objective Goal -- 5.4: Appendix -- 5.5: References -- Chapter 6: Policy Implications -- 6.1 Tailoring Policies to Vulnerabilities -- 6.2 Macroprudential Tools -- 6.2.1 Bank Capital-Oriented Tools -- 6.2.1.1 Capital Requirements that Adjust Over the Cycle -- 6.2.1.2 Forward-Looking Provisioning -- 6.2.1.3: Leverage caps -- 6.2.1.4: Loan-To-Value and Debt-Service-To-Income Caps -- 6.2.1.5: Loan-to-Deposit caps -- 6.2.1.6: Levy on Noncore Liabilities -- 6.2.1.7: Unremunerated Reserve Requirements -- 6.2.2: Relative Merits of URR versus Levies/Taxes -- 6.2.3: Relationship with other Stabilization Policies -- 6.3: Financial Integration and Institutional Design -- 6.4: Policy Choices -- 6.5: References.…”
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Creative research in music : informed practice, innovation and transcendence /

Table of Contents: “…Santos ; Remarks on music in Indonesia : Dilemmas and misunderstandings but also challenges and chances in an emerging country with a multi-ethnic society / Dieter Mack ; Seeking innovation as exploration of aesthetic / James Henry Byrne Humberstone -- Transcendence. …”
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Pathwise estimation and inference for diffusion market models / by Dokuchaev, Nikolai, Hin, Lin Yee

Table of Contents: “…2.9.1 Options and their prices2.9.2 Option pricing for a complete market; 2.9.3 Black-Scholes formula; 2.10 Pricing for an incomplete market; 2.11 A multi-stock market model; 3: Some special market models; 3.1 Mean-reverting market model; 3.1.1 Basic properties of a mean-reverting model; 3.1.2 Absence of arbitrage and the Novikov condition; 3.1.3 Proofs; 3.2 A market model with delay in coefficients; 3.2.1 Existence, regularity, and non-arbitrage properties; 3.2.2 Time discretization and restrictions on growth; 3.3 A market model with stochastic numéraire; 3.3.1 Model setting…”
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Nonlinear optimization : models and applications / by Fox, William P., 1949-

Table of Contents: “…MV Optimization 6.1 Introduction 6.2 The Hessian 6.3 Unconstrained OptimizationConvexity and The Hessian MatrixMax and Min Problems with Several VariablesChapter 7. Multi-variable Search Methods 7.1 Introduction7.2 Gradient Search7.3 Modified Newton's MethodChapter 8. …”
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The Charnoly body : a novel biomarker of mitochondrial bioenergetics / by Sharma, Sushil, Ph. D., D.M.R.I.T

Table of Contents: “…Free radical-induced compromised mitochondrial bioenergetics triggers Charnoly body formation (free radical hypothesis of charnoly body formation; stages of intracellular toxification/detoxification; biomarkers of intracelular detoxification) -- Free radical-induced molecular pathophysiology of Charnoly body and charnolosome -- Charnoly body as a novel biomarker of cell injury -- Charnoly body as a novel biomarker of compromised mitochondrial bioenergetics (biomarkers of CMB; free radical-induced CB molecular pathogenesis) -- Antioxidants prevent Charnoly body formation, augment charnolophagy, and stabilize charnolosome to enhance mitochondrial bioenergetics and intracellular detoxification (therapeutic potential of antioxidants in response to different -- Stages of a free radical attack) -- Metallothioneins inhibit charnoly body formation and confer structural and functional stability to charnolosome (therapeutic potential of metallothioneins (MTS) as CB antagonists; therapeutic potential of (MTS) as charnolosome (CS) stabilizers) -- The Charnoly body : a novel biomarker of mitochondrial bioenergetics -- Clinical significance of Charnoly body as a biomarker of compromized mitochondrial bioenergetics in multidrug resistant diseases -- Development of novel charnolopharmacotherapeutics in pharmaceutical industry by flow cytometric analysis -- Charnoly body as a novel biomarker in nanomedicine (Charnoly body, charnolophagosome, and charnlosome as potential nanotheranostic biomarkers in evidence based personalized medicine) -- Clinical significance of mitochondrial bioenergetic and Charnoly body in evidence based personalized nanotheranostics -- Translational multimodality neuroimaging of Charnoly body, charnolophagy, and charnolosome for personalized theranostics of chronic MDR diseases -- Pet radiopharmaceuticals and surface plasmon resonance spectroscopy for Charnoly body and micro-RNA based personalized theranostics -- Therapeutic potential of stem cells from different biological sources as Charnoly body anagonists, charnolophagy agonists, and charnolosome stabilizers -- Charnolopharmacotherapeutics of chronic multidrug resistant diseases by metallothionein-induced hypoxia inducible factor-1 -- Clinical significance of disease-specific Charnoly body formation -- Charnoly body in fetal alcohol syndrome -- Charnoly body in nicotinism -- Charnoly body in ZIKV disease -- Charnoly body in malnutrition -- Charnoly body in drug addiction and other chronic multi-drug-resistant diseases (therapeutic potential of MTS) -- Charnoly body in cardiovascular diseases -- Charnoly body in stroke -- Charnoly body in traumatic brain injury -- Charnolopharmacotherapy of neurodegenerative and other diseases.…”
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Divided Spaces, Contested Pasts The Heritage of the Gallipoli Peninsula. by Thys-Şenocak, Lucienne

Table of Contents: “…The ""other"" Allied dead: multi-faith burials, French cemeteries on the Gallipoli peninsulaConstruction challenges; The Allied Memorials; The Cape Helles Memorial; Post-war pilgrimage, battlefield tourism; Maintaining the cemeteries of the Gallipoli peninsula; 5 Commemoration begins for the Ottoman martyrs; Pre-WWI Ottoman memorials: Istanbul; Memorials of the Balkan Wars: Edirne; Commemorating the Ottoman dead on the Gallipoli peninsula; Commemorating the Ottoman dead off the Gallipoli peninsula; Monuments to the ""unknown soldier; Other commemorative monuments…”
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