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Biology, Physiology and Molecular Biology of Weeds / by Jugulam, Mithila

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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Ethnobotany of India.

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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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Metabolic Therapies in Orthopedics, Second Edition /

Table of Contents: “…Veltmann, PhD, DCCN and Roberta L. Kline, MD --…”
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Nuclear control of electron transport chain gene expression

Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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Nuclear control of electron transport chain gene expression

Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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Nuclear control of electron transport chain gene expression

Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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Bacterial extrachromosomal elements role in chemical detoxification and potential cancer therapy /

Table of Contents: “…Contents: Examples of degradative plasmids -- Xylene and toluene degradation by TOL plasmids -- The chloro-catechol orthocleavage pathway -- Catabolic pathways/genes in 2,4-D degradation -- Chemostatic evolution of 2,4,5-T degradative genes -- Unusual genomic structure of the 2,4,5-T genes -- Sequence characteristics of the clc element -- Evolution of s-triazine degradative plasmids -- Azurin interaction with different targets -- Structural features of azurin and immunoglobulins -- Secretion of azurin upon exposure to cancer cells -- Sequences in released extrachromosomal DNA -- Released CpG-rich DNA has anti-tumor activity.…”
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Bacterial extrachromosomal elements role in chemical detoxification and potential cancer therapy /

Table of Contents: “…Contents: Examples of degradative plasmids -- Xylene and toluene degradation by TOL plasmids -- The chloro-catechol orthocleavage pathway -- Catabolic pathways/genes in 2,4-D degradation -- Chemostatic evolution of 2,4,5-T degradative genes -- Unusual genomic structure of the 2,4,5-T genes -- Sequence characteristics of the clc element -- Evolution of s-triazine degradative plasmids -- Azurin interaction with different targets -- Structural features of azurin and immunoglobulins -- Secretion of azurin upon exposure to cancer cells -- Sequences in released extrachromosomal DNA -- Released CpG-rich DNA has anti-tumor activity.…”
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Bacterial extrachromosomal elements role in chemical detoxification and potential cancer therapy /

Table of Contents: “…Contents: Examples of degradative plasmids -- Xylene and toluene degradation by TOL plasmids -- The chloro-catechol orthocleavage pathway -- Catabolic pathways/genes in 2,4-D degradation -- Chemostatic evolution of 2,4,5-T degradative genes -- Unusual genomic structure of the 2,4,5-T genes -- Sequence characteristics of the clc element -- Evolution of s-triazine degradative plasmids -- Azurin interaction with different targets -- Structural features of azurin and immunoglobulins -- Secretion of azurin upon exposure to cancer cells -- Sequences in released extrachromosomal DNA -- Released CpG-rich DNA has anti-tumor activity.…”
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Plant abiotic stress /

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