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Function and regulation of the PDK1 kinase

Table of Contents: “…Contents: The insulin cascade -- Approaches to study the insulin signalling pathway -- GSK3 regulation of glycogen synthase by insulin -- Inactivation of GSK3 by PI3K -- GSK3 inactivation by other kinases -- Protein Kinase B (Akt) -- PKB signal transduction -- Substrate specificity of PKB -- Activation of PKB by insulin -- Phosphorylation of PKB on Thr308 and Ser473 -- PKB phosphorylation on the catalytic domain -- How insulin locates PKB to the plasma membrane -- PKB translocation to the cell membrane -- Molecular mechanism of PKB activation -- Phosphorylation of PKB -- Discovery of PDK1 -- Primary structure of human PDK1 -- PIP3 requirement for PDK1 activation of PKB -- PDK1/2 phosphorylation of PKB -- The inability of PIP3 to activate PDK1 in vitro -- PKB in muscle-specific PDK1 knockout mice -- Glycogen synthase inactivation by GSK3 -- GSK3 & glycogen synthase in muscle-specific PDK1 knockout mice -- GSK3 knock-in mice -- Analysis of GSK3 isoforms in knock-in mice -- Glycogen synthase activity in knock-in mice -- Insulin effects mediated by protein kinases -- S6K, SGK and PKC activation -- PDK1 as a "master upstream kinase" -- S6K in muscle-specific PDK1 knockout mice -- PDK1 activation of 24 AGC kinase members -- Regulation of the PDK1 pathway -- The PDK1 kinase domain -- Defining the PIF-pocket by knock-in mutation -- S6K in PDK1 PIF-pocket knock-in mutation -- The role of PIP3 binding to the PH domain -- Inhibition of PKB in PDK1 PH domain knock-in cells -- The role of the PDK1 in cancer -- Evaluation of PDK1 as a drug target -- Generation of PDK1 hypomorphic mice -- PTEN and its effect in cancer -- PDK1 and PTEN in tumours.…”
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French Silver in the J. Paul Getty Museum / by Bremer-David, Charissa

Table of Contents: “…Paul Getty as a Silver Collector and the Formation of the Museum's French Silver Collection -- Note to the Reader I: Stamps and Marks -- Note to the Reader II: Historic Units of Measure and Currency -- Catalogue -- Water Fountain (Fontaine), transformed from a Water Flagon (Buire) -- Lidded Bowl (Écuelle couverte) -- Pair of Tureens, Liners, and Stands (Paire de terrines, doublures et plateaux) -- Pair of Decorative Bronzes: Sugar Casters in the Form of Cane Field Laborers (Sucriers à poudre en forme d'ouvriers des champs de canne) -- Two Sugar Casters (Deux sucriers à poudre) -- Pair of Lidded Tureens, Liners, and Stands (Paire de pots à oille couvertes, doublures et plateaux) -- Tray for Lidded Beakers (Gantiere pour gobelets couverts) -- La machine d'argent, or Centerpiece for a Table (Surtout de table) -- Sauceboat on Stand (Sauciere sur support) -- Two Girandoles (Deux girandoles) -- Maker Biographies -- Appendix: Silver Alloy Analysis by X-ray Fluorescence Spectroscopy / Jessica Chasen, Arlen Heginbotham and Julie Wolfe.…”
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The power of systems : how policy sciences opened up the Cold War world /

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