Search Results - Fanalysis~

Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Belarusian Nation-Building in Times of War and Revolution : Nation-Building in Times of War and Revolution / by Kasmach, Lizaveta

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Transforming the Authority of the Archive : Undergraduate Pedagogy and Critical Digital Archives /

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Floundering Stability : US Foreign Policy in Egypt / by Kamel, Amir Magdy

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Universities and Economic Development in Africa : Pact, academic core and coordination /

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Cultural Encounters on China’s Ethnic Frontiers /

Table of Contents: “…The history of ethnic identity -- Millenarianism, Christian movements, and ethnic change among the Miao in Southwest China / Siu-woo Cheung -- Chinggis Khan : from imperial ancestor to ethnic hero / Almaz Khan -- The impact of urban ethnic education on modern Mongolian ethnicity, 1949-1966 / Wurlig Borchigud -- On the dynamics of Tai/Dai-Lue ethnicity : an ethnohistorical analysis / Shih-chung Hsieh -- Glossary -- References -- Contributors -- Index.…”
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Return to the Kingdom of Childhood : Re-envisioning the Legacy and Philosophical Relevance of Negritude / by Thiam, Cheikh

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Imagining the Global : Transnational Media and Popular Culture Beyond East and West / by Darling-Wolf, Fabienne

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Where Do We Go From Here? /

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African Markets and the Utu-Ubuntu Business Model. A perspective on economic informality in Nairobi : A perspective on economic informality in Nairobi / by Kinyanjui, Mary Njeri

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Social Media Activism : Water as a Common Good / by Cernison, Matteo

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Skin for Skin : Death and Life for Inuit and Innu / by Sider, Gerald M.

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The Operations of the Navy in the Dutch East Indies and the Bay of Bengal : Compiled by The War History Office of the National Defense College of Japan /

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First Hebrew Shakespeare Translations : A Bilingual Edition and Commentary / by Kahn, Lily

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Trans and Genderqueer Subjects in Medieval Hagiography /

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Theater as Data : Computational Journeys into Theater Research / by Escobar, Miguel (Theater researcher)

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Constructing Identities over Time : “Bad Gypsies” and “Good Roma” in Russia and Hungary / by Dunajeva, Jekatyerina

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Romani Liberation : A Northern Perspective on Emancipatory Struggles and Progress / by Selling, Jan

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Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists / by Copeland, Robert Allen

Table of Contents: “…Enzyme Reaction Mechanisms.2.1 Initial Binding of Substrate.2.2 Noncovalent Forces in Reversible Ligand Binding to Enzymes.2.2.1 Electrostatic Forces.2.2.2 Hydrogen Bonds.2.2.3 Hydrophobic Forces.2.2.4 van der Waals Forces.2.3 Transformations of the Bond Substrate.2.3.1 Strategies for Transition State Stabilization.2.3.2 Enzyme Active Sites Are Most Complementary to the Transition State Structure.2.4 Steady State Analysis of Enzyme Kinetics.2.4.1 Factors Affecting the Steady State Kinetic Constants.2.5 Graphical Determination of kcat and KM2.6 Reactions Involving Multiple Substates.2.6.1 Bisubstrate Reaction Mechanisms.2.7 Summary.References.3. …”
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Executing your business transformation how to engage sweeping change without killing yourself or your business /

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