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9601
Colorectal cancer and the rare variant hypothesis
Published 2020Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Series
Electronic Video -
9602
Belarusian Nation-Building in Times of War and Revolution : Nation-Building in Times of War and Revolution /
Published 2023Full text available:
Electronic eBook -
9603
Transforming the Authority of the Archive : Undergraduate Pedagogy and Critical Digital Archives /
Published 2023Full text available:
Electronic eBook -
9604
Floundering Stability : US Foreign Policy in Egypt /
Published 2023Full text available:
Electronic eBook -
9605
Universities and Economic Development in Africa : Pact, academic core and coordination /
Published 2011Full text available:
Electronic eBook -
9606
Cultural Encounters on China’s Ethnic Frontiers /
Published 1995Table of Contents: “…The history of ethnic identity -- Millenarianism, Christian movements, and ethnic change among the Miao in Southwest China / Siu-woo Cheung -- Chinggis Khan : from imperial ancestor to ethnic hero / Almaz Khan -- The impact of urban ethnic education on modern Mongolian ethnicity, 1949-1966 / Wurlig Borchigud -- On the dynamics of Tai/Dai-Lue ethnicity : an ethnohistorical analysis / Shih-chung Hsieh -- Glossary -- References -- Contributors -- Index.…”
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Electronic eBook -
9607
Return to the Kingdom of Childhood : Re-envisioning the Legacy and Philosophical Relevance of Negritude /
Published 2014Full text available:
Electronic eBook -
9608
Imagining the Global : Transnational Media and Popular Culture Beyond East and West /
Published 2015Full text available:
Electronic eBook -
9609
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9610
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9611
Social Media Activism : Water as a Common Good /
Published 2019Full text available:
Electronic eBook -
9612
Skin for Skin : Death and Life for Inuit and Innu /
Published 2014Full text available:
Electronic eBook -
9613
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9614
First Hebrew Shakespeare Translations : A Bilingual Edition and Commentary /
Published 2017Full text available:
Electronic eBook -
9615
Trans and Genderqueer Subjects in Medieval Hagiography /
Published 2021Full text available:
Electronic -
9616
Theater as Data : Computational Journeys into Theater Research /
Published 2021Full text available:
Electronic eBook -
9617
Constructing Identities over Time : “Bad Gypsies” and “Good Roma” in Russia and Hungary /
Published 2022Full text available:
Electronic eBook -
9618
Romani Liberation : A Northern Perspective on Emancipatory Struggles and Progress /
Published 2022Full text available:
Electronic eBook -
9619
Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists /
Published 2013Table of Contents: “…Enzyme Reaction Mechanisms.2.1 Initial Binding of Substrate.2.2 Noncovalent Forces in Reversible Ligand Binding to Enzymes.2.2.1 Electrostatic Forces.2.2.2 Hydrogen Bonds.2.2.3 Hydrophobic Forces.2.2.4 van der Waals Forces.2.3 Transformations of the Bond Substrate.2.3.1 Strategies for Transition State Stabilization.2.3.2 Enzyme Active Sites Are Most Complementary to the Transition State Structure.2.4 Steady State Analysis of Enzyme Kinetics.2.4.1 Factors Affecting the Steady State Kinetic Constants.2.5 Graphical Determination of kcat and KM2.6 Reactions Involving Multiple Substates.2.6.1 Bisubstrate Reaction Mechanisms.2.7 Summary.References.3. …”
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Electronic eBook -
9620