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Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…Contents: What causes selective neuronal loss in AD? -- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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PI 3-Kinase signalling enzymes & lipid messengers

Table of Contents: “…Contents: Structure of phosphatidylinositol (PI) -- Action of PI 3-kinase (PI3K) on PI -- PI3K and phospholipase C signalling -- Discovery of PI3K -- Cloning of PI3K -- PI3K isoforms in mammals -- Class I PI3K signalling pathways in cells -- PI3K in disease -- PI3K signalling pathways in cancer -- PTEN loss and T-cell lymphoma -- PI3K isoforms and therapy -- p110alpha as an oncogene.…”
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Blood brain barrier in health and disease

Table of Contents: “…Contents: The blood-brain barrier is not a static barrier -- The blood-brain barrier does inhibit drug delivery to the brain -- The blood-brain barrier is at the level of the endothelial cell cytoarchitecture that line all cerebral blood vessels in the brain -- The blood-brain barrier consists of a unique set of regulated proteins held together in a tight cytoarchitectural matrix to form a tight junction -- Stressors such as head injury, hypoxia, pain and diseases such as M.S, diabetes, Alzheimer's, cancer and stroke alter tight junction proteins of the blood-brain barrier leading to a "leak" and a loss of integrity -- Understanding what controls the integrity of the blood-brain barrier is critical if we are to understand how to treat the diseases of the brain.…”
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Adipose-immune interactions in obesity

Table of Contents: “…Contents: Adipoimmunology -- The adipose organ in obesity -- The immune system -- Adipose tissue macrophages and inflammation -- Differentiation of macrophages -- Effect of obesity on adipose tissue macrophages -- Macrophages cause insulin resistance in obesity -- ATM polarization model -- Future directions: ATM and adipose tissue -- Adipose tissue lymphocytes and inflammation -- T-lymphocytes subsets -- CD3+ T cells are present in the adipose tissue -- Age related increased bone-marrow adipocity -- Age related thymic adipocity -- T cells develop in the thymus -- The effect of thymic involution -- Lineage of thymic adipocytes -- Loss of ghrelin signaling and thymic adiposity -- reduction in naive T cells -- Adipose secretory products and immune cells -- Effect of obesity on immune function -- Obesity induced by monogenic leptin deficiency -- Dietary obesity reduces lymphoid cellularity -- Dietary obesity induces apoptosis of T cells -- Influenza infection.…”
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Antiphospholipid Syndrome (APS) from pathogenesis to treatment /

Table of Contents: “…Contents: History: fetal loss and LAC -- The use of anti-cardiolipin antigen -- GPL and past obstetric history -- The primary antiphospholipid syndrome (pAPS) -- Causes of thromboses in SLE -- Congenital thrombophilias -- APS classification criteria -- Anti-cardiolipin test (aCL) -- Autoimmunity -- Lupus and APS -- Thrombotic microangiopathy (MAPS) -- The Lucio phenomenon -- Pathogenesis -- CNS involvement in APS -- Snnedon's syndrome -- Neural injury pathogenesis in APS animal models -- Management of APS -- Asymptomatic aPL -- Thrombosis treatment -- INR recommendations -- Thrombocytopenia -- Obstetric management of APS -- Advantages and disadvantages of heparin -- Pregnancy and coumadin; clinical study -- APS and preeclampsia -- HCQ in SLE pregnancy: clinical study -- Thrombocytopenia during pregnancy -- Catastrophic APS -- Alternative therapies -- Vaccination as an APS triggering factor -- Thromboembolism and antipsychotics -- Lung adenocarcinoma and thrombosis.…”
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Trauma: code red : companion to the RCSEng definitive surgical trauma skills course /

Taylor & Francis
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Pathogenic mechanisms in prion disease

Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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The epidermis and its barrier(s)

Table of Contents: “…Contents: The importance of the skin barrier and its components -- The stratum corneum and the brick- and- mortar analogy -- Differentiation & programmed cell death of keratinocytes -- Lamellar bodies and their contents -- Barrier and moisturization -- Stratum corneum lipids and enzymes -- Epidermal tight junctions -- Measurement of trans-epidermal water loss (TEWL) -- Skin pigmentation, UV protection and P53 -- Immune barrier (Langerhans cells, Langerin & Birbek granules) -- Hair follicles (anti-microbial barrier and a route for skin penetration) -- Transdermal drug delivery -- Barrier homeostasis/up-regulation of properties -- Aves & mammals: liquid sequestration differences -- Adaptive plasticity of human skin barrier.…”
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Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…Contents: What causes selective neuronal loss in AD? -- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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Symptoms in the pharmacy a guide to the management of common illness / by Blenkinsopp, Alison

Table of Contents: “…Respiratory problems -- Colds and flu -- Cough -- Sore throat -- Allergic rhinitis -- Respiratory symptoms for direct referral -- Gastrointestinal tract problems -- Mouth ulcers -- Heartburn -- Indigestion -- Nausea and vomiting -- Motion sickness and its prevention -- Constipation -- Diarrhoea -- Irritable bowel syndrome -- Haemorrhoids -- Skin conditions -- Eczema/dermatitis -- Acne -- Athlete's foot -- Cold sores -- Warts and verrucae -- Scabies -- Dandruff -- Hair loss -- Psoriasis -- Painful conditions -- Headache -- Musculoskeletal problems -- Women's health -- Cystitis -- Dysmenorrhoea -- Vaginal thrush -- Emergency hormonal contraception -- Common symptoms in pregnancy -- Eye and ear problems -- Eye problems: the painful red eye -- Common ear problems -- Childhood conditions -- Common childhood rashes -- Colic -- Teething -- Napkin rash -- Head lice -- Threadworms (pinworms) -- Oral thrush -- Insomnia -- Prevention of heart disease.…”
An electronic book accessible through the World Wide Web; click to view

Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…Contents: What causes selective neuronal loss in AD? -- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
Get full text
Series

The epidermis and its barrier(s)

Table of Contents: “…Contents: The importance of the skin barrier and its components -- The stratum corneum and the brick- and- mortar analogy -- Differentiation & programmed cell death of keratinocytes -- Lamellar bodies and their contents -- Barrier and moisturization -- Stratum corneum lipids and enzymes -- Epidermal tight junctions -- Measurement of trans-epidermal water loss (TEWL) -- Skin pigmentation, UV protection and P53 -- Immune barrier (Langerhans cells, Langerin & Birbek granules) -- Hair follicles (anti-microbial barrier and a route for skin penetration) -- Transdermal drug delivery -- Barrier homeostasis/up-regulation of properties -- Aves & mammals: liquid sequestration differences -- Adaptive plasticity of human skin barrier.…”
Get full text
Series

Pathogenic mechanisms in prion disease

Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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Exploring grief : towards a sociology of sorrow /

Table of Contents: “…4 Magical thinking: experiences of grief and mourning in George Saunders' Lincoln in the Bardo and Jesmyn Ward's Sing, Unburied, Sing5 A story of loss: self-narration of grief and public feeling rules; 6 Writing grief: the fraught work of mourning in fiction; Part III Forms of grief; 7 The denial of grief: reflections from a decade of anthropological research on parental bereavement and child death; 8 Public mourning: displays of grief and grievance; 9 Grief in human and companion-animal loss, bonding, and dividual pet-personhood; Part IV Grief and social critique…”
Taylor & Francis
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Enterprise Risk Management in the Global Supply Chain. by Cook, Thomas A.

Table of Contents: “…Reducing International Supply Chain Costs without Beating Up Your Carrier or Service Provider When a Major Carrier Goes Bankrupt: Managing the Aftermath and Future Loss Preventive Measures ; Loss Prevention ; Global E-Commerce ; Trade Compliance ; Buying Internationally: Import Supply Chain ; Duties and Fees ; Harmonized Tariff Classification ; Country of Origin Marking ; Trade Compliance ; Reasonable Care Standard ; Customhouse Brokers ; Internal Supervision and Control ; Supply Chain Security ; Invoice Requirements ; Bonds ; Record Retention.…”
Taylor & Francis
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Sexuality and gender now : moving beyond heteronormativity /

Table of Contents: “…Sex and the consulting room -- Homophobia, heteronormativity and shame -- Working with sameness and difference: reflections on supervision with diverse sexualities -- Desire -- Losing the internal Oedipal mother and loss of sexual desire -- The primary maternal Oedipal situation and female homoerotic desire -- Mending the symbolic, when a place for male same-sex desire is not found -- Perspectives on gender -- From bisexuality to intersexuality: rethinking gender categories -- Notes on a crisis of meaning in the care of gender diverse children -- Crossing over -- Gender now -- Anonymous: a person beyond gender.…”
Taylor & Francis
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Plympton Priory a house of Augustinian Canons in south-western England in the late Middle Ages / by Fizzard, Allison D.

Table of Contents: “…The founding of Plympton Priory : background and context -- Episcopal support for the new foundation : donations to Plympton Priory from the Bishops of Exeter and their circle -- Building the endowment : lay benefactors, their motives, and their gifts -- Managing the inheritance : gains, losses, and challenges in the twelfth, thirteenth, and fourteenth centuries -- Maximizing the inheritance : Plympton Priory and its churches and chapels -- Plympton Priory and the laity : challenges to the authority of the priory -- The regular and the secular : Plympton Priory and its connections to the secular clergy -- The canons of Plympton Priory -- The patronage case : the crown, the Bishops of Exeter, and Plympton Priory -- Dissolution.…”
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Norman tradition and transcultural heritage : exchange of cultures in the 'Norman' peripheries of medieval Europe /

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Transportation and revolt : pigeons, mules, canals, and the vanishing geographies of subversive mobility / by Shell, Jacob, 1983-

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East Asian pop culture analysing the Korean wave /

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