Search Results - "vaccination"

Malaria in the mosquito

Table of Contents: “…Contents: Malaria: one of the world's foremost killers -- Malaria in the mosquito -- The mosquito midgut -- Exflagellation -- Ookinetes -- Antibodies block transmission to mosquito -- CTRP KO results in loss of infectivity to mosquito -- The time bomb theory of ookinete invasion -- Oocysts -- Interactions between Plasmodium and mosquito midgut -- Insect immunity -- Sporozoites -- A sporozoite based malaria vaccine -- Dynamics of Malaria in the mosquito.…”
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Interferons as antivirals translating basic research into clinical application /

Table of Contents: “…Contents: Emerging and re-emerging virus infections globally -- Time lag before a new vaccine is available during a pandemic -- Antivirals that are pathogen specific lead to viral resistance -- Broad spectrum antivirals needed -- Interferons -alpha -beta are produced in response to all virus infections -- Every cell/tissue will respond to interferon -- Widespread application for all virus infections.…”
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Ethical issues in international biomedical research : a casebook /

Table of Contents: “…Controversy surrounding the scientific value of the VaxGen/Aventis (RV144) phase 3 vaccine trial in Thailand -- Fair subject and community selection. …”

Viruses as anticancer weapons

Table of Contents: “…Contents: Modified viruses as friends -- Most licensed vaccines are live-attenuated viruses -- Natural oncolytic properties of viruses -- Preferential replication, efficient tumor access -- Clinical trials with oncolytic viruses -- Licensed therapeutics -- Added oncolytic properties -- Targeting: entry and post-entry -- Arming strategies -- Shielding from neutralizing antibodies -- Monitoring oncolytic virus replication in tumors -- From bench to clinic: the measles paradigm.…”
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Pathogenesis of human pulmonary tuberculosis insights from the rabbit model / by Dannenberg, Arthur M.

Table of Contents: “…Stages in the pathogenesis of human and rabbit tuberculosis -- Types of human pulmonary tuberculosis -- Liquefaction of caseous foci and cavity formation -- Delayed-type hypersensitivity, cell-mediated immunity, and antibodies in tuberculosis -- Macrophages and other cells in tuberculous lesions -- Structural components of tuberculous lesions -- Microvascular density in tuberculous lesions -- Early pulmonary lesions in rabbits -- Macrophage turnover, division, and activation in tuberculous lesions -- Lurie's pulmonary Tubercle-count method -- Natural airborne infection -- Response of rabbits to inhaled tubercle bacilli including BCG-- Characteristics of resistance and susceptibility to tuberculosis in Lurie's inbred rabbits -- Comparisons of tuberculosis in rabbits, mice, and guinea pigs -- Effects of cortisone and adrenocorticotropic hormone on tuberculosis -- Effects of estrogen, chorionic gonadotropin, and thyroid hormone on tuberculosis -- Effects of whole-body X-irradiation on tuberculosis -- Cytokine production in primary BCG lesions -- Cytokine production in reinfection bcg lesions and in tuberculin reactions -- Vascular adhesion molecules in tuberculous lesions -- Principles and guidelines for developing better tuberculosis vaccines -- Characteristics of rabbit BCG lesions and efficacies of BCG and mycobacterium microti vaccines.…”
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Introduction to malaria

Table of Contents: “…Ovale -- Hematin -- Falciparium malaria -- Malaria in pregnancy -- Innate immunity to malaria -- RBC enzyme deficiencies -- Acquired immunity -- Vaccines.…”
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Prion-like propagation of Parkinson's disease

Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
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Quantitative evaluation of HIV prevention programs

Table of Contents: “…Costs and Benefits of Imperfect HIV Vaccines: Implications for Vaccine Development and Use Douglas K Owens, Donna M. …”
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Cholera a paradigm for understanding emergence, virulence and temporal patterns of disease /

Table of Contents: “…-- Vibriophages -- Cholera incidence as a function of environmental phage isolation and concentration -- Phenotypic differences between biotypes -- Types of cholera vaccines.…”
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Molecular pathogenesis and prevention of Staphylococcus aureus infections

Table of Contents: “…-- Surface proteins and protective immunity -- Staphylococcal abscesses enable persistence -- Protein topologies in the cell wall of staphylococci -- Vaccine protection against lethal challenge -- S. aureus and human lung infections -- Active/passive immunization.…”
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Squalene current knowledge and potential therapeutical uses /

Table of Contents: “…Antioxidant properties in vivo and in vitro -- Bioavailability of squalene in animal models and in human -- Squalene may neutralize different xenobiotics -- Squalene as an anti-inflammatory agent -- Squalene and atherosclerosis -- Anti-neoplastic properties of squalene -- Mechanisms of squalene action in cancer chemoprevention and regression -- A component of skin lipids and with a role in skin ageing and pathology -- Its use to boost antigenicity of several vaccines -- Other properties -- Toxicity at high levels of intake (neuropathy and pneumonia) -- Antibodies against squalene in certain individuals.…”
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Roitt's essential immunology

Table of Contents: “…Adversarial strategies during infection. -- 13. Vaccines. -- 14. Immunodeficiency. -- 15. Hypersensitivity. -- 16. …”
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Confronting the challenge poverty, gender and HIV in South Africa / by Mulligan, Suzanne

Table of Contents: “…-- The ethics of AIDS vaccine trials in South Africa -- An alternative approach to development and poverty reduction : contributions from Amartya Sen and Muhammad Yunus -- A new starting point? …”
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Viruses and cancer

Table of Contents: “…Contents: Oncogenic viruses of animals and humans have given us insights into cancer in general -- Specific genes involved in cancer such as oncogenes and tumor suppressor genes were first discovered through research on tumor viruses -- Only a subset of viruses cause cancer -- For cancers caused by viruses, the viruses are a necessary but insufficient cause of the disease -- Cancer is multifactorial and different risk factors act together -- Vaccines hold great promise to reduce the cancer burden -- The incidence is higher in immunodeficient people -- Transplant recipients and AIDS.…”
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Probabilistic sensitivity analysis

Table of Contents: “…Contents: The primary way to account for uncertainty in health economic evaluation is probabilistic sensitivity analysis (PSA) -- PSA is increasingly demanded as a part of economic evaluation to justify a claim of cost-effectiveness for new drugs and procedures -- Economic modeling and uncertainty in economic models -- Three steps for PSA: formulating uncertainty on model inputs, computing the implied uncertainty regarding model outputs, and expressing that uncertainty in ways that are useful to decision makers -- Case study: economic model to assess cost-effectiveness of a new vaccine.…”
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The war against extensively drug resistant Mycobacterium tuberculosis intelligence acquisition /

Table of Contents: “…Tuberculosis evades immunity it should be possible to make better vaccines than BCG.…”
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Infant mortality a continuing social problem /

Table of Contents: “…: infant mortality in the Lincolnshire Fens, 1870-1900 / Sam Sneddon -- Infant mortality in Northamptonshire : a vaccination register study / Tricia James -- Urban-rural differences in infant mortality : a view from the death registers of Skye and Kilmarnock, Scotland / Eilidh Garrett --…”
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Novel immunotherapeutic proteins immunoligand /

Table of Contents: “…Contents: Potential advantages of mAB -- Challenges for mAB -- Antibody based therapeutic proteins -- Attributes of immunoligands -- Creation of Ig-based fusion proteins -- Non-cytolytic IL-2/Fc fusion protein -- Vaccine trial design -- Creation of cytolytic IL-15R antagonist fusion protein -- Application of immunoligand: immunogen for mAB production, to stain the cognate ligand, to identify cell surface cognate ligands via immunoprecipitation, to create long lived proteins to test the function of the targeting ligand in vivo and to modulate immune responses -- Challenges for immunoligands.…”
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Presence and function of SARS-CoV-2-specific T-cells in recovered patients and healthy volunteers

Table of Contents: “…Contents: The need to characterise SARS-CoV-2-specific T-cells from recovered patients -- Discovery of similar SARS-CoV-2-specific T-cells in healthy volunteers -- Possible reasons for presence of SARS-2-specific T-cells in healthy volunteers -- Differences in actions and behaviours of SARS-2-specific T-cells in patients versus volunteers -- Role of SARS-2-specific T-cells in conferring pre-existing immunity to COVID-19 (i.e. asymptomatic infections) -- Possible implications of the presence of such cells on disease progression -- Implications for vaccine development.…”
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Intracellular pathogens II Rickettsiales /

Table of Contents: “…Stevenson -- Adaptive immune responses to infection and opportunities for vaccine development (Rickettsiaceae) / Gustavo Valbuena -- Adaptive immune responses to infection and opportunities for vaccine development (Anaplasmataceae) / Susan M. …”
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