Search Results - "stem cell"

Genetically encoded Ca2+ indicators molecular scale measurements in mammals in vivo /

Table of Contents: “…Contents: Calcium Signaling -- How to study complex biology -- Genetically encoded Ca2+ indicators -- GcaMPs -- Structural basis of Ca2+ sensing -- Lineage specification of indicators in transgenic mice -- Real-time cardiac activation -- Response time considerations -- Heart development -- Cell based therapy and coupling -- Embryonic stem cells and GCaMPs -- Vascular control and pulsars -- Future directions.…”
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Bioethics issues and dilemmas /

Table of Contents: “…Childress and the Danish philosophers Jakob Rendtorff & Peter Kemp / Mette Ebbesen -- Oophorectomy specimens as a potential source of oocytes for human embryonic stem cell research / MiKyung Kim.…”
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Proteome Science

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Mechanistic aspects and therapeutic applications of RNAi

Table of Contents: “…Contents: RNAi mechanisms -- RNAi and HIV infection -- Lentiviral vector-mediated transduction of stem cells and T-cells -- Gene therapy based treatment of HIV-1 -- HIV mutants that abrogate RNAi -- Multiplexing different siRNAs and siRNAs with other antiviral RNAs to minimize viral resistance -- An HIV Tat inducible shRNA expression system -- Multiplexing shRNA with dominant negative M10 protein inhibition of HIV.…”
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Philosophical insights about modern science

Table of Contents: “….] -- Understanding molecular background of Alzheimer's disease : in search for a cure / Eva Žerovnik -- Advances in stem cell research / Anthony Atala -- Reflections on stem cells usage in restoring neurodegenerative damage / Franz-Josef Müller, Jeanne F. …”
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MicroRNA expression, detection and therapeutic strategies /

Table of Contents: “…Hussey, Joerg Haier -- Profiling of mRNAs/microRNAs and identification of microRNA targets among human mesenchymal stem cells derived from different adipose tissues / Steven Shoei-Lung Li -- MicroRNAs in regulating EMT and blood circulation metastasis of lung cancer stem cells / Jianguo Sun ... …”
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Global perspectives on science and spirituality

Table of Contents: “…Introduction / Pranab Das -- The puzzle of consciousness and experiential primacy : agency in cognitive sciences and spiritual experiences / Sangeetha Menon -- Religion, science, and lebenswelt : new interdisciplinary crossroads / Ilya Kasavin -- Science and spirituality in modern India / Makarand Paranjape -- Kokoro [mind-heart-spirit] : affirming science and religion in the Japanese context / Paul Swanson -- Daoism and the uncertainty principle / Jiang Sheng -- Whitehead reconsidered from a Buddhist perspective / Ryusei Takeda -- Sanctity of life : a reflection on human embryonic stem cell debates from an east Asian perspective / Heup Young Kim -- Aut Moses, aut Darwin? …”
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Multiple myeloma symptoms, diagnosis and treatment /

Table of Contents: “….] -- The role of PBSC in multiple myeloma : from biology to treatment / Alessandro Corso, Patrizia Zappasodi and Marzia Varettoni -- Autologous and allogeneic stem cell transplantation for multiple myeloma / Evangelos Terpos and John Meletis.…”
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Contemporary debates in bioethics

Table of Contents: “…-- Is physician-assisted suicide ever ethical? -- Should stem cell research utilizing embryonic tissue be conducted? …”
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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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The Eph receptor family

Table of Contents: “…Contents: Members of the Eph receptor and ephrin ligand families and specificity of binding interactions -- Domain structure of Eph receptors and ephrins -- Eph receptor-ephrin interactions -- Dimerization, tetramerization and further clustering in Eph-ephrin signaling -- Tyrosine phosphorylation in Eph-ephrin activation -- Modes of signal termination -- Eph-ephrin signaling pathways affecting the actin cytoskeleton and cell adhesion: Cell repulsion versus adhesion/attraction, pathways that are activated downstream of Eph receptors -- Main Eph effects on cell behavior: shaping and positioning cellular processes and cell migration -- Eph receptors in topographic mapping in the visual system -- Eph receptors in the organization of axonal projections -- Eph receptors in angiogenesis and lymphangiogenesis -- Eph receptors in stem cell proliferation and differentiation -- Eph receptors in cancer -- Eph receptors as drug targets.…”
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Endothelial cell apoptosis

Table of Contents: “…Contents: Endothelial apoptosis -- Role in tumor response to radiation therapy -- Tissue damage results from depletion of stem cells and cells with clonogenic capacity -- Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death -- Modifications of DNA damage recognition and repair pathways determine the level of tissue sensitivity to radiation -- Sphingomyelin -- Ceramide -- GI tract and bone marrow: very radiation responsive -- Growth patterns of tumors -- The two-target model for single-dose radiotherapy of experimental tumors -- Engaging the vascular component of tumor response to radiation.…”
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Deciphering neurodegeneration models and methods /

Table of Contents: “…Contents: Deciphering Neurodegeneration: Models and Methods -- The challenge of neurodegeneration -- Huge diversity in cell types -- Nature versus nurture -- Reductionism versus systems biology -- Cellular models -- Yeast -- Primary cells -- Cell lines -- Stem cells -- Model organisms -- Caenorhabditis elegans -- Drosophila melanogaster -- Zebrafish -- Danio rerio -- Rodents -- Molecular biology approaches -- Knock out and knock in -- Genomic editing -- RNAi -- Overexpression -- Gene expression -- rtPCR -- Microarrays -- RNAseq -- Protein analysis -- Immunoblot -- ELISA -- Mass spec and proteomics -- Microscopy -- Immunocytochemistry -- Live cell imaging -- Electrophysiology.…”
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Treatment of multiple myeloma and related disorders

Table of Contents: “…Harousseau -- Allogeneic stem cell transplantation for multiple myeloma / William I. …”
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Cancer biomarkers

Table of Contents: “…Oral cancer : biomarkers, hallmarks, stem cell origin, and clinical implications / Athanassios Kyrgidis -- Molecular signatures of infectious agents : application in human cancer control / Madhulika Singh, Amit Kumar Srivastava, Yogeshwer Shukla -- Protein isoforms and their special role as cancer biomarkers / Ana M. …”
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Multiple sclerosis causes, diagnosis and management /

Table of Contents: “….] -- Heterogeneous aetiology of multiple sclerosis / Seyed Amir Bahreini, Hamid Zahednasab, Mohammad Saadatnia -- Multiple sclerosis / Daria Dinacci -- Multiple sclerosis, an autoimmune disease of rickettsial origin amenable to treatment by a new strategy / Bo Frykholm -- Mini autologous hematopoietic stem cell transplantation in multiple sclerosis / A.A. …”
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Etiology and Morphogenesis of Congenital Heart Disease From Gene Function and Cellular Interaction to Morphology /

Table of Contents: “…Conduction System and Arrhythmia -- Regulation of vertebrate conduction system development -- Cardiac Pacemaker Development from a Tertiary Heart Field -- Endothelin receptor type A expressing cell population in the inflow tract contributes to chamber formation -- Specific isolation of HCN4 positive cardiac pace-making cells derived from embryonic stem cell -- Part IX. Current Molecular Mechanism in Cardiovascular Development -- Combinatorial functions of transcription factors and epigenetic factors in heart development and disease -- Pcgf5 contributes to PRC1 (Polycomb repressive complex 1) in developing cardiac cells -- non-coding RNAs in cardiovascular disease -- Part X. iPS Cells and Regeneration in Congenital Heart Diseases -- Human pluripotent stem cells to model congenital heart disease -- Engineered cardiac tissues generated from immature cardiac and stem-cell derived cells: Multiple approaches and outcomes -- Dissecting the left heart hypoplasia by pluripotent stem cells -- Lentiviral gene transfer to iPS cells; toward the cardiomyocyte differentiation of Pompe disease-specific iPS cells -- Molecular analysis of long-term cultured cardiac stem cells for cardiac regeneration -- Epicardial contribution in neonatal heart regeneration -- Part XI. …”
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Genome Editing in Neurosciences

Table of Contents: “…Introduction -- In vitro modeling of complex neurological diseases -- Aquatic model organisms in neurosciences : the genome editing revolution -- Genome-wide genetic screening in the mammalian CNS -- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish -- Dissecting the role of synaptic proteins with CRISPR -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- Neuroscience research using non-human primate models and genome editing -- Multiscale genome engineering: Genome-wide screens and targeted approaches -- Using Genome Engineering to Understand Huntington’s Disease -- Therapeutic gene editing in muscles and muscle stem cells.…”
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Fulfilling the Promise of Technology Transfer Fostering Innovation for the Benefit of Society /

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Endogenous bioelectrical signals in development, regeneration, and neoplasm

Table of Contents: “…Contents: Defining bioelectricity -- Sources of bioelectrical signals -- Big questions about bioelectricity -- Membrane voltage and cell plasticity -- History of the field of bioelectricity -- Applying exogenous electric fields in vitro -- Microelectrode impalement -- Detection of extracellular ion flux -- Investigating signals in pattern formation -- Inverse pharmacological screen -- Transmembrane voltage gradient characterization -- Loss- and gain-of-function analyses -- Synthesizing data into a predictive model -- Control of cell behavior by electric fields -- Mammalian stem cell differentiation -- Cell orientation and outgrowth -- Transepithelial potentials, electric fields, cancer -- Mechanisms of electric field sensing by cells -- Bioelectric signals in 3D morphogenesis -- A pathway for tail regeneration -- Transmembrane potential in tail regeneration -- V-ATPase function in tail regeneration -- Using voltage- and pH-sensitive dyes -- Induction of the V-ATPase following injury -- Electrogenic targets in mitosis upregulation -- Axon patterning requires specific ion fluxes -- Gene expression requires specific ion flows -- Ion flux and induction of regeneration -- Voltage gradients control large-scale axial polarity -- Transmembrane potential and cell behavior -- The Goldman equation -- Missexpressing specific ion transporter mRNAs -- Melanocyte behavior & transmembrane potential -- Taking advantage of endogenous ion transport -- Controlling transmembrane potential -- Modulation of transmembrane potential -- Controlling proliferation rates using K channels -- Cell-autonomous mechanisms -- Non-cell-autonomous mechanisms -- Bioelectrical signals and canonical pathways -- Bioelectric gradients and gene expression -- Information carried by bioelectric signals -- Bioelectrical mechanisms, DNA, mRNA & protein -- Control of ion flux as a master regulator -- Applications in cancer, stem cells & regeneration -- Light-gated ion transporters.…”
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