Search Results - "proteins"

The InsP3 receptor Ca2+ release channel

Table of Contents: “…Contents: The inositol trisphosphate receptor signaling system -- Dynamic properties of cytoplasmic Ca2+ signals -- Structural properties of the InsP3R -- Patch clamp electrophysiology of the InsP3R channel -- Permeation properties of the channel -- Channel gating regulation by Calcium and InsP3 -- Channel mechanisms that account for graded Ca2+ release -- Isoform specific differences in channel gating -- Channel regulation by ATP and interacting proteins.…”
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Series (Calcium signaling I)
Series (Endoplasmic reticulum)

Introduction to free radicals and the oxygen paradox oxidative stress in biology, aging & disease /

Table of Contents: “…Contents: The oxygen paradox -- Oxygen origin -- Free radicals, oxidants and oxidative stress -- Sources of free radicals -- Environmental toxins -- Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation -- Medical and dental sources of free radicals: x-rays, g-rays, drugs -- DNA damage and oxygen radical toxicity -- Antioxidant compounds and enzymes -- The dismutation of superoxide -- Mechanisms of antioxidant enzymes -- Antioxidant defense and repair systems -- Removal of oxidized DNA bases and DNA repair -- Lipolysis and the repair of oxidized lipids and lipid membranes -- Selective proteolytic degradation of oxidized proteins -- The LON protease -- Adaptation to oxidative stress -- Long-term effects of free radicals and oxidative stress: aging and disease.…”
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Therapy in cancer 2008 quo vadis? /

Table of Contents: “…Contents: Why pursuing new therapeutic approaches in cancer is important -- Prevention and screening -- Current cancer therapy: non-surgical -- Most chemotherapy targets DNA -- Chemotherapy effects -- Current state of cancer therapy: efficacy and toxicity -- Molecular pathogenesis of cancer -- Pursuing targeted therapy in cancers -- Targeted biologic therapies -- Evolving targets and agents -- Shift from chemotherapy to targeted agents -- Clinically established molecular targets in malignancies -- Targeted therapy: proteins and small molecules -- Changes brought about by targeting: efficacy and toxicity -- Biomarkers in drug development -- What is currently known: angiogenesis -- The VEGF family and its receptors -- Bevacizumab and Sorafenib -- Does toxicity correlate with response? …”
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Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Spectrum of mitochondrial diseases -- Mitochondrial metabolic pathway -- MtDNA mutations and disease -- Pathological features -- MELAS -- Genetic epidemiology of mtDNA mutations -- Structural components of respiratory chain complexes -- Mitochondrial DNA metabolism -- Mitochondrial proteins and oxidative phosphorylation -- Fatal mtDNA depletion syndrome -- POLG mutations -- Environmental influences on PD causation -- PARK genes -- Huntington's disease and mtDNA mutations -- Genetic basis of Friedreich's ataxia -- Mitochondrial toxins.…”
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Series (Mitochondrial biogenesis)
Series (Neurodegenerative diseases)

The InsP3 receptor Ca2+ release channel

Table of Contents: “…Contents: The inositol trisphosphate receptor signaling system -- Dynamic properties of cytoplasmic Ca2+ signals -- Structural properties of the InsP3R -- Patch clamp electrophysiology of the InsP3R channel -- Permeation properties of the channel -- Channel gating regulation by Calcium and InsP3 -- Channel mechanisms that account for graded Ca2+ release -- Isoform specific differences in channel gating -- Channel regulation by ATP and interacting proteins.…”
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Series (Calcium signaling I)
Series (Endoplasmic reticulum)

Introduction to free radicals and the oxygen paradox oxidative stress in biology, aging & disease /

Table of Contents: “…Contents: The oxygen paradox -- Oxygen origin -- Free radicals, oxidants and oxidative stress -- Sources of free radicals -- Environmental toxins -- Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation -- Medical and dental sources of free radicals: x-rays, g-rays, drugs -- DNA damage and oxygen radical toxicity -- Antioxidant compounds and enzymes -- The dismutation of superoxide -- Mechanisms of antioxidant enzymes -- Antioxidant defense and repair systems -- Removal of oxidized DNA bases and DNA repair -- Lipolysis and the repair of oxidized lipids and lipid membranes -- Selective proteolytic degradation of oxidized proteins -- The LON protease -- Adaptation to oxidative stress -- Long-term effects of free radicals and oxidative stress: aging and disease.…”
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Series

Therapy in cancer 2008 quo vadis? /

Table of Contents: “…Contents: Why pursuing new therapeutic approaches in cancer is important -- Prevention and screening -- Current cancer therapy: non-surgical -- Most chemotherapy targets DNA -- Chemotherapy effects -- Current state of cancer therapy: efficacy and toxicity -- Molecular pathogenesis of cancer -- Pursuing targeted therapy in cancers -- Targeted biologic therapies -- Evolving targets and agents -- Shift from chemotherapy to targeted agents -- Clinically established molecular targets in malignancies -- Targeted therapy: proteins and small molecules -- Changes brought about by targeting: efficacy and toxicity -- Biomarkers in drug development -- What is currently known: angiogenesis -- The VEGF family and its receptors -- Bevacizumab and Sorafenib -- Does toxicity correlate with response? …”
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Herpes simplex virus and varicella-zoster virus Helicase-Primase inhibitors

Table of Contents: “…Contents: Herpesvirus infections in man -- Diseases caused by alphaherpesvirus, HSV and VZV -- Immunocompromised hosts -- Infection, latency and reactivation -- Morphology of herpesvirus virion -- Productive replication cycle -- The herpesvirus genome -- HSV and VZV antiviral therapy -- Nucleoside analogue therapy -- Historical prospective -- Genes coding for proteins targeted by antivirals -- Inhibitors of DNA synthesis -- A new target -- HSV helicase-primase complex -- Clinical potential of Helicase primase inhibitors (HPIs) -- Studying HPI in vivo -- Antiviral efficacy -- Dose response -- The effects of HPI on HSV latency -- The development of HPI antiviral drug resistance -- HPI resistant mutants growth and pathogenicity.…”
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Viral epitranscriptomics

Table of Contents: “…Contents: Epitranscriptomic modifications (m6A, m5C and ac4c modifications) -- mRNA epitranscriptomic modification -- Loss of m6A modifiers and IVA replication -- m6A modifiers: YTHDF proteins and METTL3 -- Epitranscriptomic modifications in HIV-1 -- m5C modifiers: NSUN2 -- ac4c modifiers: NAT10 -- m6A and ac4c increase viral mRNA stability while m5C increases viral mRNA translation.…”
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Biologically active natural products : microbial technologies and phyto-pharmaceuticals in drug development /

Table of Contents: “…Azadirachta indica: Imperative Mini-Opinions on an Ethnopharmacological Savior / Anshda Bhatnagar and Debarshi Kar Mahapatra -- Arsenals of Pharmacotherapeutically Active Proteins and Peptides: Old Wine in a New Bottle / Kirti Dubli -- Biotechnological Potential of Hydrogen-Oxidizing Bacteria / Tatiana Gr. …”
Taylor & Francis
OCLC metadata license agreement

Sustainable Downstream Processing of Microalgae for Industrial Application. by Maity, Sunil Kumar

Table of Contents: “…Integrated Approach for the Sustainable Extraction of Carbohydrates and Proteins from Microalgae. Part 3: Optimized Downstream Processing of Microalgae. 9. …”
Taylor & Francis
OCLC metadata license agreement

Proteomics for food authentication /

Table of Contents: “…Proteomics for food authentication / Ignacio Ortea, Gavin O'Connor, Alain Maquet -- 1-DE and 2-DE -- in-gel tryptic digestion / Semih Ötleş, Vasfiye Hazal Özyurt -- Non-directed analysis / Dev Kant Shandilya -- Targeted proteomics for food authentication / Devarajan Thangadurai, Mojtaba Kordrostami, Saher Islam, Arun Kashivishwanath Shettar, Jeyabalan Sangeetha, Mohammad Mafakheri, Jasmin Habeeb, Abdel Rahman Mohammad Said Al-Tawaha, Steffi Simmi Maxim and Ravichandra Hospet -- A MALDI-TOF MS approach for mammalian, human, and formula milks' profiling / Laura Di Francesco, Francesco Di Girolamo, Maurizio Mennini , Andrea Masott, Guglielmo Salvatori, Giuliano Rigon, Fabrizio Signore, Emanuela Pietranton, Margherita Scapaticci, Isabella Lante, Bianca Maria Goffredo, Oscar Mazzina, Ahmed Ibrahim Elbousify, Paola Roncada, Andrea Dotta, Alessandro Fiocchi, and Lorenza Putignani -- MALDI-TOF-MS analysis of foods / Leo M.L. Nollet -- Whole protein analysis using LC-MS/MS for food authentication / Jeyabalan Sangeetha, Arun Kashivishwanath Shettar, Devarajan Thangadurai, Chethan Jambanna Dandin, Ravichandra Hospet, Bhavisha Prakashbhai Sheth, Saher Islam, Abdel Rahman Mohammad Said Al-Tawaha, Mojtaba Kordrostami and Mohammad Mafakheri -- Proteomic authentication of dairy products / Saher Islam, Devarajan Thangadurai -- Proteomic tools for improved processing of dry-cured meats / Leticia Mora, Fidel Toldrá -- Fish / Marco Alexandre Cavaco Cerqueira, Ana Paula Farinha, Denise Schrama, Márcio Júlio Vicente Moreira, Cláudia Sofia Ferreira Raposo de Magalhães, Pedro Miguel Leal Rodrigues -- Proteomics in authentication of wine / Javed Ahamad, Javed Ahmad, Showkat R. …”
Taylor & Francis
OCLC metadata license agreement

Parkinson's at 200 years an update on Parkinson's research in 2017 /

Table of Contents: “…Contents: Shaking palsy: first milestone in Parkinson's disease -- Key areas of research, unanswered questions and unmet needs -- Drugs that manipulate dopamine metabolism -- Pinpointing specific genes relevant to Parkinson's disease -- Parkinson's and gut microbiota -- Parkinson's and protein aggregation -- Role of immune system in Parkinson's disease -- Novel/Future treatments and drugs -- Prediction of Parkinson's disease.…”
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Unity and diversity in microbial genomes

Table of Contents: “…Contents: Host-pathogen interaction -- Microbial genomics -- Properties and functions of microbes: their genomes, protein coding, sequences and putative biochemical pathways -- The concept of the "universal" minimal genome -- Strategies used by obligatory intracellular parasites for genome reduction and survival -- The use of comparative genomics in understanding the concept of the "backbone genome" -- Differential gene loss and overlapping genes -- Drug targets.…”
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Accelerating drug discovery with machine learning and AI

Table of Contents: “…Contents: Machine-learning techniques -- Artificial intelligence methods -- Drug discovery -- Molecular modeling -- Choosing a disease -- Identifying a drug target -- Choosing the bioassay -- AlphaFold 2: Protein structure prediction -- Computer-assisted drug design -- NIH IDG-DREAM -- Predictive vs. generative models -- Molecular design with deep reinforcement learning.…”
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Series

Parkinson's at 200 years an update on Parkinson's research in 2017 /

Table of Contents: “…Contents: Shaking palsy: first milestone in Parkinson's disease -- Key areas of research, unanswered questions and unmet needs -- Drugs that manipulate dopamine metabolism -- Pinpointing specific genes relevant to Parkinson's disease -- Parkinson's and gut microbiota -- Parkinson's and protein aggregation -- Role of immune system in Parkinson's disease -- Novel/Future treatments and drugs -- Prediction of Parkinson's disease.…”
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Series

Unity and diversity in microbial genomes

Table of Contents: “…Contents: Host-pathogen interaction -- Microbial genomics -- Properties and functions of microbes: their genomes, protein coding, sequences and putative biochemical pathways -- The concept of the "universal" minimal genome -- Strategies used by obligatory intracellular parasites for genome reduction and survival -- The use of comparative genomics in understanding the concept of the "backbone genome" -- Differential gene loss and overlapping genes -- Drug targets.…”
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Series

Unity and diversity in microbial genomes

Table of Contents: “…Contents: Host-pathogen interaction -- Microbial genomics -- Properties and functions of microbes: their genomes, protein coding, sequences and putative biochemical pathways -- The concept of the "universal" minimal genome -- Strategies used by obligatory intracellular parasites for genome reduction and survival -- The use of comparative genomics in understanding the concept of the "backbone genome" -- Differential gene loss and overlapping genes -- Drug targets.…”
Get full text
Series

Parkinson's at 200 years an update on Parkinson's research in 2017 /

Table of Contents: “…Contents: Shaking palsy: first milestone in Parkinson's disease -- Key areas of research, unanswered questions and unmet needs -- Drugs that manipulate dopamine metabolism -- Pinpointing specific genes relevant to Parkinson's disease -- Parkinson's and gut microbiota -- Parkinson's and protein aggregation -- Role of immune system in Parkinson's disease -- Novel/Future treatments and drugs -- Prediction of Parkinson's disease.…”
Get full text
Series

Accelerating drug discovery with machine learning and AI

Table of Contents: “…Contents: Machine-learning techniques -- Artificial intelligence methods -- Drug discovery -- Molecular modeling -- Choosing a disease -- Identifying a drug target -- Choosing the bioassay -- AlphaFold 2: Protein structure prediction -- Computer-assisted drug design -- NIH IDG-DREAM -- Predictive vs. generative models -- Molecular design with deep reinforcement learning.…”
Get full text
Series