Search Results - "proteins"

Selenium and male fertility

Table of Contents: “…Contents: Selenium in nutrition -- Selenocysteine as the 21st aminoacid -- Eukaryotic selenocysteine-containing proteins -- GPx4 and the Sec-glutathione peroxidases -- The redox chemistry of GPx4 and spermatogenesis -- Selenium and male fertility -- Whole body KO of GPx4 -- Selenoproteins involved in spermatogenesis -- Spermatozoa GPx4 activity as a biomarker of fertility.…”
Get full text
Series

Vaccines in the modern world

Table of Contents: “…-- Vaccine composition -- Vaccines in common use -- Type of immune response induced by vaccination -- Impact on disease incidence -- Smallpox: the first vaccine -- Vaccines against polio and meningitis -- What is a conjugated vaccine -- Reverse vaccinology -- Novartis MenB protein vaccine -- Vaccines can now be based on DNA.…”
Get full text
Series

Nucleic acids in chemistry and biology

Table of Contents: “…Introduction and overview -- DNA and RNA structure -- Nucleosides and nucleotides -- Synthesis of oligonucleotides -- Nucleic acids in biotechnology -- Genes and genomes -- RNA structure and function -- Covalent interactions of nucleic acids with small molecules and their repair -- Reversible small molecule-nucleic acid interactions -- Protein-nucleic acid interactions -- Physical and structural techniques applied to nucleic acids.…”
An electronic book accessible through the World Wide Web; click to view

Nobel prizes and nature's surprises / by Norrby, Erling

Table of Contents: “…A magician of virology from Australia -- A divided Nobel Prize and a new era in immunology -- More Nobel Prizes in immunology -- Immunity, infections and transplantations -- Transgressing borders in science and scenes of life -- Making sense of hearing : art and science -- Unraveling the complexity of protein folding -- "It's so beautiful, you see, so beautiful!" …”
An electronic book accessible through the World Wide Web; click to view

Mitochondrial biogenesis as a result of exercise

Table of Contents: “…Contents: Mitochondrial reticulum in skeletal muscle -- Biochemical adaptations to activity -- Transcriptional activation of exercise responsive genes -- Influence of exercise intensity and duration -- Principles of protein turnover -- Kinetic basis of training adaptations -- Role of transient increases in metabolic genes -- Signals implicated in activity-induced mitochondrial biogenesis -- AMP kinase -- Calcium mediated signaling events.…”
Get full text
Series

Chaperonin CCT mediated folding of actin, energetic landscapes and cell cycle control

Table of Contents: “…Contents: CCT, an ATPase with specific protein substrates -- Sequential allosteric model (2001) and allosteric cycle (2007) -- Actin/CCT interaction -- Actin standard free energy level diagram -- Functional yeast CCT -- Anaphase promoting complex and WD40 propellers -- Disruption of CCT function in vivo in mammalian cell lines -- CCT/disease associations.…”
Get full text
Series

Mitochondrial biogenesis as a result of exercise

Table of Contents: “…Contents: Mitochondrial reticulum in skeletal muscle -- Biochemical adaptations to activity -- Transcriptional activation of exercise responsive genes -- Influence of exercise intensity and duration -- Principles of protein turnover -- Kinetic basis of training adaptations -- Role of transient increases in metabolic genes -- Signals implicated in activity-induced mitochondrial biogenesis -- AMP kinase -- Calcium mediated signaling events.…”
Get full text
Series

Mitochondrial biogenesis as a result of exercise

Table of Contents: “…Contents: Mitochondrial reticulum in skeletal muscle -- Biochemical adaptations to activity -- Transcriptional activation of exercise responsive genes -- Influence of exercise intensity and duration -- Principles of protein turnover -- Kinetic basis of training adaptations -- Role of transient increases in metabolic genes -- Signals implicated in activity-induced mitochondrial biogenesis -- AMP kinase -- Calcium mediated signaling events.…”
Get full text
Series

Potassium channels types, structure and blockers /

Table of Contents: “…Martinez -- Slow potassium channel dysfunction in amyotrophic lateral sclerosis and its in vivo evaluation by threshold tracking / Hiroyuki Nodera -- Characteristics of potassium channels of smooth muscle in health and disease / Yasushi Sakai, Michio Hashimoto -- Individual potassium channel proteins display characteristic patterns in rate cerebellum and olfactory bulb / Angelike Gortzen ... …”
An electronic book accessible through the World Wide Web; click to view

The impact of genomic architecture and diversity on infectious diseases

Table of Contents: “…Contents: Genome related paradoxes -- Sequencing the human genome -- Homologs of human proteins -- The genetic basis of human complexity -- Human genetics vs. mouse genetics -- Exons and introns in the human and mouse genomes -- Conclusions about eukaryotic genomes -- Viral genomes and reverse vaccinology -- Pathogenesis of viral infections -- Infectomics and virogenomics of different viruses (SARS, HPV, Dengue & E71) -- Diagnostic virology -- Gene knockdown strategies & siRNA.…”
Get full text
Series

Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease

Table of Contents: “…Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.…”
Get full text
Series

Host genetic factors that limit HIV and AIDS

Table of Contents: “…Contents: Overview of candidate gene association studies of HIV and AIDS -- Key role for genetic variants involved in cell entry and host defenses -- Homozygous CCR5 32 basepair deletion prevents HIV Infection -- Acquired Immunity: HLA Class 1 proteins -- Key mediators of HIV progression -- Innate Protection: HLA and KIRS interactions in HIV disease -- Overview of Genome Wide Association Studies (GWAS) -- Overwhelming influence of HLA class I on HIV Progression and control of HIV viral load -- Non-HLA genetic associations with extreme phenotypes -- No new variants identified that prevent HIV infection -- Discovery of chromosome 22 associations with HIV-associated nephropathy -- Future studies -- Epigenetic, proteomic, functional studies -- Potential role of rare variants.…”
Get full text

Herpes simplex virus and varicella-zoster virus Helicase-Primase inhibitors

Table of Contents: “…Contents: Herpesvirus infections in man -- Diseases caused by alphaherpesvirus, HSV and VZV -- Immunocompromised hosts -- Infection, latency and reactivation -- Morphology of herpesvirus virion -- Productive replication cycle -- The herpesvirus genome -- HSV and VZV antiviral therapy -- Nucleoside analogue therapy -- Historical prospective -- Genes coding for proteins targeted by antivirals -- Inhibitors of DNA synthesis -- A new target -- HSV helicase-primase complex -- Clinical potential of Helicase primase inhibitors (HPIs) -- Studying HPI in vivo -- Antiviral efficacy -- Dose response -- The effects of HPI on HSV latency -- The development of HPI antiviral drug resistance -- HPI resistant mutants growth and pathogenicity.…”
Get full text
Series

The InsP3 receptor Ca2+ release channel

Table of Contents: “…Contents: The inositol trisphosphate receptor signaling system -- Dynamic properties of cytoplasmic Ca2+ signals -- Structural properties of the InsP3R -- Patch clamp electrophysiology of the InsP3R channel -- Permeation properties of the channel -- Channel gating regulation by Calcium and InsP3 -- Channel mechanisms that account for graded Ca2+ release -- Isoform specific differences in channel gating -- Channel regulation by ATP and interacting proteins.…”
Get full text
Series (Calcium signaling I)
Series (Endoplasmic reticulum)

Introduction to free radicals and the oxygen paradox oxidative stress in biology, aging & disease /

Table of Contents: “…Contents: The oxygen paradox -- Oxygen origin -- Free radicals, oxidants and oxidative stress -- Sources of free radicals -- Environmental toxins -- Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation -- Medical and dental sources of free radicals: x-rays, g-rays, drugs -- DNA damage and oxygen radical toxicity -- Antioxidant compounds and enzymes -- The dismutation of superoxide -- Mechanisms of antioxidant enzymes -- Antioxidant defense and repair systems -- Removal of oxidized DNA bases and DNA repair -- Lipolysis and the repair of oxidized lipids and lipid membranes -- Selective proteolytic degradation of oxidized proteins -- The LON protease -- Adaptation to oxidative stress -- Long-term effects of free radicals and oxidative stress: aging and disease.…”
Get full text
Series

Cross-genomic analysis of human disease genes

Table of Contents: “…Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approx. 30% are highly conserved sequences -- The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes -- Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system -- Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome -- Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis -- LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third -- EF inhibits PKA dependent Hedgehog signaling in the fly wing.…”
Get full text
Series

Fundamentals of fluorescence imaging /

Taylor & Francis
Taylor & Francis
OCLC metadata license agreement

Viral epitranscriptomics

Table of Contents: “…Contents: Epitranscriptomic modifications (m6A, m5C and ac4c modifications) -- mRNA epitranscriptomic modification -- Loss of m6A modifiers and IVA replication -- m6A modifiers: YTHDF proteins and METTL3 -- Epitranscriptomic modifications in HIV-1 -- m5C modifiers: NSUN2 -- ac4c modifiers: NAT10 -- m6A and ac4c increase viral mRNA stability while m5C increases viral mRNA translation.…”
Get full text
Series

Herpes simplex virus and varicella-zoster virus Helicase-Primase inhibitors

Table of Contents: “…Contents: Herpesvirus infections in man -- Diseases caused by alphaherpesvirus, HSV and VZV -- Immunocompromised hosts -- Infection, latency and reactivation -- Morphology of herpesvirus virion -- Productive replication cycle -- The herpesvirus genome -- HSV and VZV antiviral therapy -- Nucleoside analogue therapy -- Historical prospective -- Genes coding for proteins targeted by antivirals -- Inhibitors of DNA synthesis -- A new target -- HSV helicase-primase complex -- Clinical potential of Helicase primase inhibitors (HPIs) -- Studying HPI in vivo -- Antiviral efficacy -- Dose response -- The effects of HPI on HSV latency -- The development of HPI antiviral drug resistance -- HPI resistant mutants growth and pathogenicity.…”
Get full text
Series

Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Spectrum of mitochondrial diseases -- Mitochondrial metabolic pathway -- MtDNA mutations and disease -- Pathological features -- MELAS -- Genetic epidemiology of mtDNA mutations -- Structural components of respiratory chain complexes -- Mitochondrial DNA metabolism -- Mitochondrial proteins and oxidative phosphorylation -- Fatal mtDNA depletion syndrome -- POLG mutations -- Environmental influences on PD causation -- PARK genes -- Huntington's disease and mtDNA mutations -- Genetic basis of Friedreich's ataxia -- Mitochondrial toxins.…”
Get full text
Series (Mitochondrial biogenesis)
Series (Neurodegenerative diseases)