Search Results - "proteins"

Cell cycle control by the ubiquitin system in mammals

Table of Contents: “…-- Cyclin dependent kinases -- Advantages of regulated proteolysis -- The hierarchy of the ubiquitin pathway -- E2s and E3s ensure substrate specificity -- Regulation of the cell cycle by proteolysis -- Two major ubiquitin ligases control cell cycle progression -- SCF ubiquitin ligases -- Mechanism of catalysis by the SCF -- F-box proteins -- Skp2 -- betaTrcp1 and betaTrcp2 -- DNA replication stress -- Fbxw7 -- Anaphase promoting complex or cyclosome -- Cell cycle, ubiquitin system and cancer.…”
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Lens development and disorders molecular biology and genetics /

Table of Contents: “…Contents: Overview of lens anatomy and function -- Lens macrostructure/microanatomy and lens transparency -- Molecular mechanisms of the vertebrate lens development -- Factors contributing to normal lens physiology -- The role of proteins integral to lenticular transparency -- Genetics of lens abnormalities -- The importance of precision diagnoses in congenital lens abnormality cases -- Next generation sequencing technologies in the diagnosis of lens abnormalities.…”
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Lysosomal storage diseases

Table of Contents: “…Contents: Lysosomes are multifunctional -- Lysosome related organelles -- Complexity & functions of lysosomal proteins -- Lysosomal storage diseases -- Sphingolipid lysosomal storage diseases as an example -- Lysosomal diseases: multimorbidity disorders -- Pathogenic cascade beyond the Lysosomal System -- Specific therapies approved for some diseases -- Molecular mechanisms and therapeutic approaches of LSDs -- Lysosomal enzymes -- ERTs: approved or in advanced clinical trials -- Approved small molecules: SRT & EET -- Multiple gene therapy trials: enzyme deficiencies -- Cellular organelles targeted by LSD therapies -- Lysosomal & neurodegenerative diseases.…”
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Engineering practices for milk products : dairyceuticals, novel technologies, and quality /

Table of Contents: “…Functional Properties of Milk Proteins / Veena Nagarajappa, Neelam Upadhyay, Rekha Chawla, Santosh Kumar Mishra, and B. …”
Taylor & Francis
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Biopharmaceutical production technology

Table of Contents: “…Upstream technologies ; pt. 2. Protein recovery ; pt. 3. Advances in process development -- v. 2, pt. 4. …”
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Targeting cancer designing drugs against Hsp90 /

Table of Contents: “…Contents: Heat shock protein 90 (Hsp90), a target in cancer -- Discovery of the first known Hsp90 inhibitor, geldanamycin -- Use of geldanamycin to understand the role of Hsp90 in malignant transformation -- Discovery of novel Hsp90 inhibitors -- Development and applications of Hsp90 inhibitors.…”
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Targeting cancer designing drugs against Hsp90 /

Table of Contents: “…Contents: Heat shock protein 90 (Hsp90), a target in cancer -- Discovery of the first known Hsp90 inhibitor, geldanamycin -- Use of geldanamycin to understand the role of Hsp90 in malignant transformation -- Discovery of novel Hsp90 inhibitors -- Development and applications of Hsp90 inhibitors.…”
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Targeting cancer designing drugs against Hsp90 /

Table of Contents: “…Contents: Heat shock protein 90 (Hsp90), a target in cancer -- Discovery of the first known Hsp90 inhibitor, geldanamycin -- Use of geldanamycin to understand the role of Hsp90 in malignant transformation -- Discovery of novel Hsp90 inhibitors -- Development and applications of Hsp90 inhibitors.…”
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Lipid metabolism and the endoplasmic reticulum

Table of Contents: “…Contents: Biological roles of lipids -- Major lipid classes found in the cell -- Metabolism of lipids in the ER -- Examples of lipidmetabolizing enzymes found in the ER -- Strategies for maintaining cellular cholesterol homeostasis -- Activation of gene expression by SREBPs -- Situations that cause ER stress -- The unfolded protein response (UPR) and lipid metabolism.…”
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SOD1-related ALS what has it told us about motor neuron degeneration? Part 1 of 2 /

Table of Contents: “…Contents: Motor neurons -- Amyotrophic Lateral Sclerosis (ALS) -- Motor Neuron Disease (MND) -- SOD1 gene -- Protein function of SOD1 -- SOD1 mutations -- ALS / MND caused by SOD1 mutations -- Heterogeneity of ALS / MND -- Models of SOD1 related ALS / MND.…”
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Lipid metabolism and the endoplasmic reticulum

Table of Contents: “…Contents: Biological roles of lipids -- Major lipid classes found in the cell -- Metabolism of lipids in the ER -- Examples of lipidmetabolizing enzymes found in the ER -- Strategies for maintaining cellular cholesterol homeostasis -- Activation of gene expression by SREBPs -- Situations that cause ER stress -- The unfolded protein response (UPR) and lipid metabolism.…”
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Lipid metabolism and the endoplasmic reticulum

Table of Contents: “…Contents: Biological roles of lipids -- Major lipid classes found in the cell -- Metabolism of lipids in the ER -- Examples of lipidmetabolizing enzymes found in the ER -- Strategies for maintaining cellular cholesterol homeostasis -- Activation of gene expression by SREBPs -- Situations that cause ER stress -- The unfolded protein response (UPR) and lipid metabolism.…”
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SOD1-related ALS what has it told us about motor neuron degeneration? Part 1 of 2 /

Table of Contents: “…Contents: Motor neurons -- Amyotrophic Lateral Sclerosis (ALS) -- Motor Neuron Disease (MND) -- SOD1 gene -- Protein function of SOD1 -- SOD1 mutations -- ALS / MND caused by SOD1 mutations -- Heterogeneity of ALS / MND -- Models of SOD1 related ALS / MND.…”
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A primer on cell and molecular biology / by Running, Mark P.

Table of Contents: “…Transduction and signaling -- The basic elements of cell signaling systems -- G-protein coupled receptors (GPCRs) -- Protein-tyrosine phosphorylation -- Differences in plant and animal receptor signaling -- The role of calcium as an intracellular second -- Messenger -- Convergence, divergence, and crosstalk among different signaling pathways --…”
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Structure-based study of viral replication with CD-ROM /

Table of Contents: “…Human rhinovirus cell entry and uncoating -- Role of lipid microdomains in influenza virus multiplication -- Functions of integrin alpha2beta1, a collagen receptor, in the internalization of echovirus-- Entry mechanism of murine and SARS coronaviruses: similarity and dissimilarity-- Hepatitis viruses, signaling events, and modulation of the innate host response -- Virus-cell interaction of HCV -- RNA replication of hepatitis C virus -- Structure and dynamics in viral RNA packaging -- Rational design of viral protein structures with predetermined immunological properties -- Bioinformatics resources for the study of viruses at the Virginia Bioinformatics Institute -- Virus architecture probed by atomic force microscopy -- Filovirus assembly and budding -- Challenges in designing HIV Env immunogens for developing a vaccine -- Insights into the caliciviridae family -- Mathematical approaches for stoichiometric quantification in studies of viral assembly and DNA packaging -- Virus-like particles of fish nodavirus -- The assembly of the double-layered capsids of phytoreoviruses -- Structure and assembly of human herpesviruses: new insights from cryo-electron microscopy and tomography -- Human papillomavirus type 16 capsid proteins: immunogenicity and possible use as prophylactic vaccine antigens -- Chimeric recombinant Hepatitis E virus-like particles presenting foreign epitopes as a novel vector of vaccine by oral administration -- Nucleocapsid protein of hantaviruses (bunyaviridae): structure and functions -- Astrovirus replication: an overview -- DNA vaccines.…”
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Genetic variation in gene regulation

Table of Contents: “…Contents: Expression Quantitative Trait Loci: linking genetic variation to changes in gene regulation -- How do SNPs impact gene regulation -- HapMap cell lines as a model system for studying expression variation -- eQTL analysis -- dsQTL -- Histone marks -- Protein-specific QTLs.…”
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Genetic variation in gene regulation

Table of Contents: “…Contents: Expression Quantitative Trait Loci: linking genetic variation to changes in gene regulation -- How do SNPs impact gene regulation -- HapMap cell lines as a model system for studying expression variation -- eQTL analysis -- dsQTL -- Histone marks -- Protein-specific QTLs.…”
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Genetic variation in gene regulation

Table of Contents: “…Contents: Expression Quantitative Trait Loci: linking genetic variation to changes in gene regulation -- How do SNPs impact gene regulation -- HapMap cell lines as a model system for studying expression variation -- eQTL analysis -- dsQTL -- Histone marks -- Protein-specific QTLs.…”
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Huntington's disease and HD-like disorders

Table of Contents: “…Contents: Huntington's disease -- Huntington's disease like disorders -- Chorea -- Anticipation -- Pathobiology of Huntington's disease -- Huntingtin protein misfolding -- Aggregation -- Ubiquitous expression including in peripheral tissues -- Juvenile Huntington's disease/Westphal variant -- Psychiatric, behavioural and cognitive symptomatology -- HD phenocopies -- C9Orf72 and SCA17.…”
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Voltage-dependent gating of ion channels

Table of Contents: “…Contents: Voltage-dependent ion channels -- Critical to proper nerve and muscle function -- Voltage sensitivity is mediated by positively charged segments of the protein -- These voltage sensors move outward with depolarization to trigger channel opening -- The return of one sensor to the resting positions closes the channel -- Hypothesized mechanisms of voltage sensor movement are detailed.…”
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