Search Results - "proteins"

Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Spectrum of mitochondrial diseases -- Mitochondrial metabolic pathway -- MtDNA mutations and disease -- Pathological features -- MELAS -- Genetic epidemiology of mtDNA mutations -- Structural components of respiratory chain complexes -- Mitochondrial DNA metabolism -- Mitochondrial proteins and oxidative phosphorylation -- Fatal mtDNA depletion syndrome -- POLG mutations -- Environmental influences on PD causation -- PARK genes -- Huntington's disease and mtDNA mutations -- Genetic basis of Friedreich's ataxia -- Mitochondrial toxins.…”
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Series (Mitochondrial biogenesis)
Series (Neurodegenerative diseases)

HIV preintegration complexes

Table of Contents: “…HIV-2 Vpx -- HIV-1 Vpr interaction factors -- HIV-2: model system for PIC nuclear import -- Vpx cellular localization -- Ability of Vpx-NLS mutant viruses to infect arrested and dividing U937 cells -- Nuclear localization signal of HIV-2 Vpx -- Vpx interaction with HSP 40 -- Heat shock proteins and viruses -- Over-expression of DNAJB6 causes reduction of Vpx packaging in VLP -- Down regulation of DNAJB6 reduces nuclear import of HIV-2 PIC -- Novel mechanism of Vpx-mediated PIC import.…”
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Plasmids copy number control by antisense RNAs /

Table of Contents: “…Contents: Negative feedback control of plasmid replication -- General properties of plasmids -- Plasmid R1 -- Copy number control of plasmid R1 -- Inhibition and translational coupling -- Interaction between folded RNAs -- Copy number control of ColE1-type plasmids -- Regulation by induced RNA folding change -- Copy number control of plasmid pIP501 -- RNAIII induces transcription termination -- Copy number control of IncIa/IncB plasmids -- Inhibition of activator pseudoknot -- Kinetic control of copy number -- Binding pathways: a hierarchy of steps -- The CopA/CopT four helix junction structure -- Fast RNA-RNA recognition -- Helper proteins.…”
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Lipid metabolism

Table of Contents: “…-- CR uptake into the liver -- Hepatic lipoprotein pathways -- Size of VLDL determines LDL size -- Role of apo E in lipoprotein catabolism -- Apo E polymorphism -- Cellular cholesterol homeostasis -- LDL receptor involved in cellular cholesterol homeostasis -- Intracellular cholesterol regulated gene expression -- "Reverse cholesterol transport" by HDL -- Lipid exchange proteins -- Normal levels for plasmalipid.…”
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Therapy in cancer 2008 quo vadis? /

Table of Contents: “…Contents: Why pursuing new therapeutic approaches in cancer is important -- Prevention and screening -- Current cancer therapy: non-surgical -- Most chemotherapy targets DNA -- Chemotherapy effects -- Current state of cancer therapy: efficacy and toxicity -- Molecular pathogenesis of cancer -- Pursuing targeted therapy in cancers -- Targeted biologic therapies -- Evolving targets and agents -- Shift from chemotherapy to targeted agents -- Clinically established molecular targets in malignancies -- Targeted therapy: proteins and small molecules -- Changes brought about by targeting: efficacy and toxicity -- Biomarkers in drug development -- What is currently known: angiogenesis -- The VEGF family and its receptors -- Bevacizumab and Sorafenib -- Does toxicity correlate with response? …”
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Iron metabolism and innate immunity

Table of Contents: “…Contents: Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts -- Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins -- The cellular component of this response causes a marked decrease in extracellular iron concentration -- Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration -- It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation -- Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias.…”
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Physiology of molluscs a collection of selected reviews.

Taylor & Francis
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Lysosomal storage diseases

Table of Contents: “…Contents: Lysosomes are multifunctional -- Lysosome related organelles -- Complexity & functions of lysosomal proteins -- Lysosomal storage diseases -- Sphingolipid lysosomal storage diseases as an example -- Lysosomal diseases: multimorbidity disorders -- Pathogenic cascade beyond the Lysosomal System -- Specific therapies approved for some diseases -- Molecular mechanisms and therapeutic approaches of LSDs -- Lysosomal enzymes -- ERTs: approved or in advanced clinical trials -- Approved small molecules: SRT & EET -- Multiple gene therapy trials: enzyme deficiencies -- Cellular organelles targeted by LSD therapies -- Lysosomal & neurodegenerative diseases.…”
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Lens development and disorders molecular biology and genetics /

Table of Contents: “…Contents: Overview of lens anatomy and function -- Lens macrostructure/microanatomy and lens transparency -- Molecular mechanisms of the vertebrate lens development -- Factors contributing to normal lens physiology -- The role of proteins integral to lenticular transparency -- Genetics of lens abnormalities -- The importance of precision diagnoses in congenital lens abnormality cases -- Next generation sequencing technologies in the diagnosis of lens abnormalities.…”
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HIV preintegration complexes

Table of Contents: “…HIV-2 Vpx -- HIV-1 Vpr interaction factors -- HIV-2: model system for PIC nuclear import -- Vpx cellular localization -- Ability of Vpx-NLS mutant viruses to infect arrested and dividing U937 cells -- Nuclear localization signal of HIV-2 Vpx -- Vpx interaction with HSP 40 -- Heat shock proteins and viruses -- Over-expression of DNAJB6 causes reduction of Vpx packaging in VLP -- Down regulation of DNAJB6 reduces nuclear import of HIV-2 PIC -- Novel mechanism of Vpx-mediated PIC import.…”
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Plasmids copy number control by antisense RNAs /

Table of Contents: “…Contents: Negative feedback control of plasmid replication -- General properties of plasmids -- Plasmid R1 -- Copy number control of plasmid R1 -- Inhibition and translational coupling -- Interaction between folded RNAs -- Copy number control of ColE1-type plasmids -- Regulation by induced RNA folding change -- Copy number control of plasmid pIP501 -- RNAIII induces transcription termination -- Copy number control of IncIa/IncB plasmids -- Inhibition of activator pseudoknot -- Kinetic control of copy number -- Binding pathways: a hierarchy of steps -- The CopA/CopT four helix junction structure -- Fast RNA-RNA recognition -- Helper proteins.…”
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Lipid metabolism

Table of Contents: “…-- CR uptake into the liver -- Hepatic lipoprotein pathways -- Size of VLDL determines LDL size -- Role of apo E in lipoprotein catabolism -- Apo E polymorphism -- Cellular cholesterol homeostasis -- LDL receptor involved in cellular cholesterol homeostasis -- Intracellular cholesterol regulated gene expression -- "Reverse cholesterol transport" by HDL -- Lipid exchange proteins -- Normal levels for plasmalipid.…”
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Spindle movement and checkpoint control during mitosis in yeast

Table of Contents: “…Contents: Cell cycle checkpoints for partitioning the genome -- Budding yeast as a model system for the study of genome distribution -- How nuclei are segregated in yeast -- Evidence for a spindle position checkpoint -- Model for checkpoint based on Tem1 -- Movie assay for checkpoint -- Search for upstream inputs -- Screen for checkpoint mutants -- Septins dual role in checkpoint -- Inputs to Lte1 -- Bud6 and microtubule capture -- Potential pathway for Bud6 -- Bud6 and microtubule-binding proteins -- Overexpression analysis -- Inhibition of Lte1 in the cold.…”
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The DNA damage response

Table of Contents: “…Contents: Genomic instability in cancer -- DNA structure checkpoint -- ATM, ATR and related proteins -- Xenopus laevis egg extract as a model system -- Sensing the DNA break -- Mre11/Rad50/Nbs1 complex -- Sensing DNA double strand breaks: current model -- ATM activation by ssDNA molecules -- ssDNA oligo generation is MRN dependent -- ATM, ATR and Mre11 complex deficiency in vertebrates -- DNA structure checkpoint and mitotic catastrophe in vertebrates -- ATM/ATR targets in mitosis after DNA damage -- Centrosome as a target of DNA damage response.…”
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Cell cycle control by the ubiquitin system in mammals

Table of Contents: “…-- Cyclin dependent kinases -- Advantages of regulated proteolysis -- The hierarchy of the ubiquitin pathway -- E2s and E3s ensure substrate specificity -- Regulation of the cell cycle by proteolysis -- Two major ubiquitin ligases control cell cycle progression -- SCF ubiquitin ligases -- Mechanism of catalysis by the SCF -- F-box proteins -- Skp2 -- betaTrcp1 and betaTrcp2 -- DNA replication stress -- Fbxw7 -- Anaphase promoting complex or cyclosome -- Cell cycle, ubiquitin system and cancer.…”
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HIV preintegration complexes

Table of Contents: “…HIV-2 Vpx -- HIV-1 Vpr interaction factors -- HIV-2: model system for PIC nuclear import -- Vpx cellular localization -- Ability of Vpx-NLS mutant viruses to infect arrested and dividing U937 cells -- Nuclear localization signal of HIV-2 Vpx -- Vpx interaction with HSP 40 -- Heat shock proteins and viruses -- Over-expression of DNAJB6 causes reduction of Vpx packaging in VLP -- Down regulation of DNAJB6 reduces nuclear import of HIV-2 PIC -- Novel mechanism of Vpx-mediated PIC import.…”
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Series

Plasmids copy number control by antisense RNAs /

Table of Contents: “…Contents: Negative feedback control of plasmid replication -- General properties of plasmids -- Plasmid R1 -- Copy number control of plasmid R1 -- Inhibition and translational coupling -- Interaction between folded RNAs -- Copy number control of ColE1-type plasmids -- Regulation by induced RNA folding change -- Copy number control of plasmid pIP501 -- RNAIII induces transcription termination -- Copy number control of IncIa/IncB plasmids -- Inhibition of activator pseudoknot -- Kinetic control of copy number -- Binding pathways: a hierarchy of steps -- The CopA/CopT four helix junction structure -- Fast RNA-RNA recognition -- Helper proteins.…”
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Spindle movement and checkpoint control during mitosis in yeast

Table of Contents: “…Contents: Cell cycle checkpoints for partitioning the genome -- Budding yeast as a model system for the study of genome distribution -- How nuclei are segregated in yeast -- Evidence for a spindle position checkpoint -- Model for checkpoint based on Tem1 -- Movie assay for checkpoint -- Search for upstream inputs -- Screen for checkpoint mutants -- Septins dual role in checkpoint -- Inputs to Lte1 -- Bud6 and microtubule capture -- Potential pathway for Bud6 -- Bud6 and microtubule-binding proteins -- Overexpression analysis -- Inhibition of Lte1 in the cold.…”
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Lipid metabolism

Table of Contents: “…-- CR uptake into the liver -- Hepatic lipoprotein pathways -- Size of VLDL determines LDL size -- Role of apo E in lipoprotein catabolism -- Apo E polymorphism -- Cellular cholesterol homeostasis -- LDL receptor involved in cellular cholesterol homeostasis -- Intracellular cholesterol regulated gene expression -- "Reverse cholesterol transport" by HDL -- Lipid exchange proteins -- Normal levels for plasmalipid.…”
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Series

The DNA damage response

Table of Contents: “…Contents: Genomic instability in cancer -- DNA structure checkpoint -- ATM, ATR and related proteins -- Xenopus laevis egg extract as a model system -- Sensing the DNA break -- Mre11/Rad50/Nbs1 complex -- Sensing DNA double strand breaks: current model -- ATM activation by ssDNA molecules -- ssDNA oligo generation is MRN dependent -- ATM, ATR and Mre11 complex deficiency in vertebrates -- DNA structure checkpoint and mitotic catastrophe in vertebrates -- ATM/ATR targets in mitosis after DNA damage -- Centrosome as a target of DNA damage response.…”
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Series