Search Results - "proteins"

The DNA damage response

Table of Contents: “…Contents: Genomic instability in cancer -- DNA structure checkpoint -- ATM, ATR and related proteins -- Xenopus laevis egg extract as a model system -- Sensing the DNA break -- Mre11/Rad50/Nbs1 complex -- Sensing DNA double strand breaks: current model -- ATM activation by ssDNA molecules -- ssDNA oligo generation is MRN dependent -- ATM, ATR and Mre11 complex deficiency in vertebrates -- DNA structure checkpoint and mitotic catastrophe in vertebrates -- ATM/ATR targets in mitosis after DNA damage -- Centrosome as a target of DNA damage response.…”
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Cell cycle control by the ubiquitin system in mammals

Table of Contents: “…-- Cyclin dependent kinases -- Advantages of regulated proteolysis -- The hierarchy of the ubiquitin pathway -- E2s and E3s ensure substrate specificity -- Regulation of the cell cycle by proteolysis -- Two major ubiquitin ligases control cell cycle progression -- SCF ubiquitin ligases -- Mechanism of catalysis by the SCF -- F-box proteins -- Skp2 -- betaTrcp1 and betaTrcp2 -- DNA replication stress -- Fbxw7 -- Anaphase promoting complex or cyclosome -- Cell cycle, ubiquitin system and cancer.…”
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Legionella pneumophila an intracellular pathogen of phagocytes /

Table of Contents: “…Contents: The legionella life cycle -- Identification of the dot and icm genes -- The dot and icm genes define a new type IV secretion system -- Intracellular replication -- Endocytic membrane transport -- Transport of the Legionella-containing vacuole -- Legionella replication -- The dot/icm system modulates Arf and Rab1 -- Can we identify Legionella proteins that modulate Arf and Rab1 function? -- Activation of Arf by Legionella -- Can Legionella modulate the function of other host GTPases? …”
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Chromatographic Methods Development

Taylor & Francis
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Measles

Table of Contents: “…Contents: Introduction to measles as a systemic rash disease -- Measles virus and replication -- Virus proteins for cell entry, fusion and formation of multinucleated giant cells -- Transmission, systemic spread, immune response, complications and clearance -- Vaccine characteristics, efficacy and coverage -- Measles epidemiology -- Problems with control.…”
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The biology of cancer

Table of Contents: “…Contents: Present general hallmarks of cancer -- Explain how cancer is initiated through activation of oncogenes and deactivation of tumour suppressors -- Highlight what makes these oncogenes and tumour suppressors so special -- Show different ways in which these proteins can modify cell signalling to lead to cancer -- Introduce the notion that cancer is not only about the cancer cell but also about the environment -- Give examples of how we can exploit this combined knowledge to develop cancer therapeutics and the associated challenges.…”
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An overview of the neuropathology of neurodegenerative diseases

Table of Contents: “…. -- The pathological proteins for each disease are discussed and the types of pathological lesions formed.…”
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Localisation of ionotropic glutamate receptors in the central nervous system

Table of Contents: “…Contents: Introduction to the molecular organisation, functional roles and distribution of glutamate receptors (GluRs) -- Choice of localisation strategies for ionotropic GluR (iGluR) ligand binding sites, mRNAs and receptor proteins -- Overview or autoradiography, in situ hybridisation histochemistry and immunolocalisation of iGluRs in the central nervous system using examples -- Comparison of the advantages and limitations various localisation approaches used for the investigation of iGluRs.…”
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Plant cell wall structure and biosynthesis /

Table of Contents: “…Contents: Overview of plant cell wall functions -- Primary and secondary walls -- Types of polymers in plant cell walls -- Organization of plant cell walls / plant cell wall models -- Cell wall proteins -- Structure and synthesis of lignin -- Structure and synthesis of cellulose -- Structure and synthesis of hemicelluloses -- Structure and synthesis of pectic polysaccharides.…”
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Cellular calcium (Ca2+) buffers

Table of Contents: “…Contents: The Ca2+ signaling toolkit -- The EF-hand family of Ca2+-binding proteins -- Biophysical properties of Ca2+ buffers determine their function -- Ca2+ buffers as intracellular Ca2+ signal modulators -- The «slow» buffer parvalbumin (PV) affects fast-twitch muscle function -- Ca2+ buffers modulate short-term plasticity of synaptic transmission -- Phenotypes of Ca2+ buffer knockout mice -- The Ca2+ homeostasome.…”
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Regulation of apoptosis lessons from Drosophila and their implications for human health and disease /

Table of Contents: “…Contents: Many different signals influence apoptosis -- "Gas" and "brake" model of apoptosis -- Reaper, Hid and Grim -- IAPs and cancer -- Use of Drosophila -- Ubiquitination and apoptosis -- diap1 -- In proliferating tissues, damage induced cell death is compensated by extra growth of the neighboring cells -- Evidence for the "active model" of compensatory proliferation -- Regulation of caspase activation -- Cytochrome c is required for effector caspase activation in Drosophila spermatids -- Cyt-c-d and other apoptosome proteins are required for normal developmental apoptosis in the Drosophila retina -- Generation of Sept4-null mice -- Acquired characteristics of cancer cells.…”
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Cell cycle a complex network of signals regulating cell proliferation /

Table of Contents: “…Contents: The cell cycle is a complex system which is highly regulated in a temporal manner, via checkpoints and positive and negative feedback loops -- Two processes must alternate during eukaryotic cell division: S-phase and M-phase entry -- Cell cycle checkpoints -- The cell cycle engine -- Cyclin D-CDK activity -- Not all CDKs and cyclins are involved in the regulation of cell cycle -- Cell cycle and pRb family proteins -- Cell cycle control pathways.…”
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Legionella pneumophila an intracellular pathogen of phagocytes /

Table of Contents: “…Contents: The legionella life cycle -- Identification of the dot and icm genes -- The dot and icm genes define a new type IV secretion system -- Intracellular replication -- Endocytic membrane transport -- Transport of the Legionella-containing vacuole -- Legionella replication -- The dot/icm system modulates Arf and Rab1 -- Can we identify Legionella proteins that modulate Arf and Rab1 function? -- Activation of Arf by Legionella -- Can Legionella modulate the function of other host GTPases? …”
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Regulation of apoptosis lessons from Drosophila and their implications for human health and disease /

Table of Contents: “…Contents: Many different signals influence apoptosis -- "Gas" and "brake" model of apoptosis -- Reaper, Hid and Grim -- IAPs and cancer -- Use of Drosophila -- Ubiquitination and apoptosis -- diap1 -- In proliferating tissues, damage induced cell death is compensated by extra growth of the neighboring cells -- Evidence for the "active model" of compensatory proliferation -- Regulation of caspase activation -- Cytochrome c is required for effector caspase activation in Drosophila spermatids -- Cyt-c-d and other apoptosome proteins are required for normal developmental apoptosis in the Drosophila retina -- Generation of Sept4-null mice -- Acquired characteristics of cancer cells.…”
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Cell cycle a complex network of signals regulating cell proliferation /

Table of Contents: “…Contents: The cell cycle is a complex system which is highly regulated in a temporal manner, via checkpoints and positive and negative feedback loops -- Two processes must alternate during eukaryotic cell division: S-phase and M-phase entry -- Cell cycle checkpoints -- The cell cycle engine -- Cyclin D-CDK activity -- Not all CDKs and cyclins are involved in the regulation of cell cycle -- Cell cycle and pRb family proteins -- Cell cycle control pathways.…”
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Legionella pneumophila an intracellular pathogen of phagocytes /

Table of Contents: “…Contents: The legionella life cycle -- Identification of the dot and icm genes -- The dot and icm genes define a new type IV secretion system -- Intracellular replication -- Endocytic membrane transport -- Transport of the Legionella-containing vacuole -- Legionella replication -- The dot/icm system modulates Arf and Rab1 -- Can we identify Legionella proteins that modulate Arf and Rab1 function? -- Activation of Arf by Legionella -- Can Legionella modulate the function of other host GTPases? …”
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Cellular calcium (Ca2+) buffers

Table of Contents: “…Contents: The Ca2+ signaling toolkit -- The EF-hand family of Ca2+-binding proteins -- Biophysical properties of Ca2+ buffers determine their function -- Ca2+ buffers as intracellular Ca2+ signal modulators -- The «slow» buffer parvalbumin (PV) affects fast-twitch muscle function -- Ca2+ buffers modulate short-term plasticity of synaptic transmission -- Phenotypes of Ca2+ buffer knockout mice -- The Ca2+ homeostasome.…”
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Plant cell wall structure and biosynthesis /

Table of Contents: “…Contents: Overview of plant cell wall functions -- Primary and secondary walls -- Types of polymers in plant cell walls -- Organization of plant cell walls / plant cell wall models -- Cell wall proteins -- Structure and synthesis of lignin -- Structure and synthesis of cellulose -- Structure and synthesis of hemicelluloses -- Structure and synthesis of pectic polysaccharides.…”
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Localisation of ionotropic glutamate receptors in the central nervous system

Table of Contents: “…Contents: Introduction to the molecular organisation, functional roles and distribution of glutamate receptors (GluRs) -- Choice of localisation strategies for ionotropic GluR (iGluR) ligand binding sites, mRNAs and receptor proteins -- Overview or autoradiography, in situ hybridisation histochemistry and immunolocalisation of iGluRs in the central nervous system using examples -- Comparison of the advantages and limitations various localisation approaches used for the investigation of iGluRs.…”
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An overview of the neuropathology of neurodegenerative diseases

Table of Contents: “…. -- The pathological proteins for each disease are discussed and the types of pathological lesions formed.…”
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