Search Results - "proteins"

Plasmid rolling-circle (RC) replication

Table of Contents: “…Contents: Rolling circle replicating (RCR) plasmids -- Functional organization of rolling-circle replicating plasmids -- Model for plasmid rolling-circle replication -- Initiation and termination of replication in plasmids carrying two pT181 dsos -- DNA sequence and structure of the pT181 origin -- Initiator proteins of RCR plasmids -- Comparison of the replication origins of the plasmids of pT181 family -- Rep-DNA specificity -- Role of individual monomers of the Rep protein -- Purification of RepC heterodimers -- PcrA helicase -- Role of PcrA helicase in plasmid RC replication -- Conversion of ss to ds DNA -- Single strand origins of replication -- Lagging-strand replication.…”
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The molecular biology of the inositol trisphosphate receptor

Table of Contents: “…Contents: Activation of the IP3-receptor (IP3R), a major endoplasmic Calcium release channel in many cells, is activated by the second messenger inositol 1,4,5-trisphosphate (IP3) -- The IP3R is unique in that it can integrate signals from numerous cellular pathways via a myriad of inputs which include nucleotide binding, phosphorylation, Calcium binding and protein-protein interactions -- A diverse range of cellular functions are modulated by the IP3R including contraction/excitation, secretion, gene expression, cell cycle, apoptosis and cellular growth -- The nodal properties of the IP3R and the mechanisms by which this occurs.…”
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Plasmid rolling-circle (RC) replication

Table of Contents: “…Contents: Rolling circle replicating (RCR) plasmids -- Functional organization of rolling-circle replicating plasmids -- Model for plasmid rolling-circle replication -- Initiation and termination of replication in plasmids carrying two pT181 dsos -- DNA sequence and structure of the pT181 origin -- Initiator proteins of RCR plasmids -- Comparison of the replication origins of the plasmids of pT181 family -- Rep-DNA specificity -- Role of individual monomers of the Rep protein -- Purification of RepC heterodimers -- PcrA helicase -- Role of PcrA helicase in plasmid RC replication -- Conversion of ss to ds DNA -- Single strand origins of replication -- Lagging-strand replication.…”
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Peroxynitrite biochemistry oxidation and nitration reactions

Table of Contents: “…Contents: Nitric oxide reaction with superoxide radical: the formation of peroxynitrite -- Peroxynitrite-mediated thiol oxidation -- Peroxynitrite decomposition pathways: one vs two-electron oxidation processes -- Thyl radicals and sulfenic acids -- Peroxynitrite kinetics and stopped flow analysis -- Peroxynitrite reaction with fact reaction thiols, the case of peroxiredoxins -- Peroxynitrite reaction with transition metals -- The reaction of peroxynitrite with carbon dioxide: the formation of carbonate radicals -- Proton-catalyzed homolysis of peroxynitrite to hydroxyl radicals -- Lipid peroxidation and nitration -- Protein tyrosine nitration, a free radical process -- Protein tyrosine nitration in disease states -- Peroxynitrite and mitochondrial dysfunction -- Role of peroxynitrite in pathology -- Peroxynitrite therapeutics.…”
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Type I interferons in innate immunity to viral infections

Table of Contents: “…Contents: Evolving immune response -- Interferons -- Antiviral effects -- IFNalfa/beta induction -- Role of IFNalfa/beta in fighting off viruses and infection -- Activation of immune response cascades during viral challenges -- Immunoregulation -- NK cells during viral infections -- Innate lymphocytes in defense -- Regulation of NK cell responses by IFNalfa/beta and IL-12 -- IFN signaling -- STAT1 in defense against infection -- Kinetics of cell and cytokine responses to LCMV infections -- STAT expression in NK cells -- Type 1 IFN receptor association -- Gene expression and protein-protein interactions for regulating type 1 IFN effects -- Interferon treatment -- Interferon ablation.…”
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Autophagy as a barrier to infection

Table of Contents: “…Contents: Autophagosome biogenesis -- Autophagy a regulated intersection of the secretory and endosomal pathways -- Genetic analysis in yeast has accelerated autophagy research -- Autophagy is inhibited by mTOR -- Autophagosome biogenesis is coordinated by a cascade of Atg proteins -- Autophagosomes mature rapidly in C57Bl/6 macrophages -- A wide variety of pathogens encounter the autophagy pathway -- Autophagy in infection and immunity -- Illustrations: Legionella pneumophila -- Shigella flexnerii -- Crohns' disease -- Mycobacterium tuberculosis -- Naip5 NOD-like receptor cytosolic surveillance protein -- Inflammasome components coordinate autophagy and pyroptosis as barriers to infection -- Autophagy enhances MHCI and MHCII antigen presentation.…”
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Emerging infectious diseases a guide to diseases, causative agents, and surveillance / by Beltz, Lisa A., 1960-

Table of Contents: “…Parasitic infections -- pt. 5. Infectious proteins -- pt. 6. Special issues in infectious diseases.…”
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A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
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HIV and the pathogenesis of AIDS by Levy, Jay A.

Table of Contents: “…Discovery, structure, heterogeneity, and origins of HIV -- Features of HIV transmission -- Steps involved in HIV: cell interaction and virus entry -- Acute HIV infection and cells susceptible to HIV infection -- Intracellular control of HIV replication -- Cytopathic properties of HIV -- Viral proteins determining biologic features of HIV -- Effect of HIV on various tissues and organ systems in the host -- Innate immune responses in HIV infection -- Humoral immune responses to HIV infection -- T-lymphocyte immune responses in HIV infection -- HIV infection and development of cancer -- Overall features of HIV pathogenesis: prognosis for long-term survival -- Antiviral therapies -- Vaccine development.…”
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Inorganic electrochemistry theory, practice and application / by Zanello, Piero

Table of Contents: “…Basic aspects of electrochemistry : Fundamentals of electrode reactions -- Voltammetric techniques -- Practical aspects : Basic equipment for electrochemical measurements -- Applicative aspects : The electrochemical behaviour of first row transition metal metallocenes -- The electrochemical behaviour of transition metal complexes -- Metal complexes containing redox-active ligands -- Electrochemically induced structural modifications -- Transition metal clusters -- The reactivity of transition metal complexes -- Superconductors in electrochemistry -- Molecular metal wires: an electrochemical inspection -- The 'direct' electrochemistry of redox-active proteins -- Linear correlations between the redox potential and other chemical and physico-chemical parameters -- Appendices: Physical constants ; SI base unites ; Derived SI units ; SI prefixes ; Conversion factors ; The Greek alphabet.…”
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Telomerase composition, functions and clinical implications /

Table of Contents: “…Telomerase beyond telomeres : new roles for an old enzyme / Gabriele Saretzki -- Telomerase and telomeric proteins : a life beyond telomeres / Ilaria Chiodi, Cristina Belgiovine, Chiara Mondello -- Histone deacetylase inhibition as an anticancer telomerase-targeting strategy / Ruman Rahman -- Telomerase role in pituitary adenomas / A. …”
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Lysosomal storage diseases

Table of Contents: “…Contents: Lysosomes are multifunctional -- Lysosome related organelles -- Complexity & functions of lysosomal proteins -- Lysosomal storage diseases -- Sphingolipid lysosomal storage diseases as an example -- Lysosomal diseases: multimorbidity disorders -- Pathogenic cascade beyond the Lysosomal System -- Specific therapies approved for some diseases -- Molecular mechanisms and therapeutic approaches of LSDs -- Lysosomal enzymes -- ERTs: approved or in advanced clinical trials -- Approved small molecules: SRT & EET -- Multiple gene therapy trials: enzyme deficiencies -- Cellular organelles targeted by LSD therapies -- Lysosomal & neurodegenerative diseases.…”
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Lens development and disorders molecular biology and genetics /

Table of Contents: “…Contents: Overview of lens anatomy and function -- Lens macrostructure/microanatomy and lens transparency -- Molecular mechanisms of the vertebrate lens development -- Factors contributing to normal lens physiology -- The role of proteins integral to lenticular transparency -- Genetics of lens abnormalities -- The importance of precision diagnoses in congenital lens abnormality cases -- Next generation sequencing technologies in the diagnosis of lens abnormalities.…”
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Localisation of ionotropic glutamate receptors in the central nervous system

Table of Contents: “…Contents: Introduction to the molecular organisation, functional roles and distribution of glutamate receptors (GluRs) -- Choice of localisation strategies for ionotropic GluR (iGluR) ligand binding sites, mRNAs and receptor proteins -- Overview or autoradiography, in situ hybridisation histochemistry and immunolocalisation of iGluRs in the central nervous system using examples -- Comparison of the advantages and limitations various localisation approaches used for the investigation of iGluRs.…”
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Plant cell wall structure and biosynthesis /

Table of Contents: “…Contents: Overview of plant cell wall functions -- Primary and secondary walls -- Types of polymers in plant cell walls -- Organization of plant cell walls / plant cell wall models -- Cell wall proteins -- Structure and synthesis of lignin -- Structure and synthesis of cellulose -- Structure and synthesis of hemicelluloses -- Structure and synthesis of pectic polysaccharides.…”
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Cellular calcium (Ca2+) buffers

Table of Contents: “…Contents: The Ca2+ signaling toolkit -- The EF-hand family of Ca2+-binding proteins -- Biophysical properties of Ca2+ buffers determine their function -- Ca2+ buffers as intracellular Ca2+ signal modulators -- The «slow» buffer parvalbumin (PV) affects fast-twitch muscle function -- Ca2+ buffers modulate short-term plasticity of synaptic transmission -- Phenotypes of Ca2+ buffer knockout mice -- The Ca2+ homeostasome.…”
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Regulation of apoptosis lessons from Drosophila and their implications for human health and disease /

Table of Contents: “…Contents: Many different signals influence apoptosis -- "Gas" and "brake" model of apoptosis -- Reaper, Hid and Grim -- IAPs and cancer -- Use of Drosophila -- Ubiquitination and apoptosis -- diap1 -- In proliferating tissues, damage induced cell death is compensated by extra growth of the neighboring cells -- Evidence for the "active model" of compensatory proliferation -- Regulation of caspase activation -- Cytochrome c is required for effector caspase activation in Drosophila spermatids -- Cyt-c-d and other apoptosome proteins are required for normal developmental apoptosis in the Drosophila retina -- Generation of Sept4-null mice -- Acquired characteristics of cancer cells.…”
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Features of mammalian CNS barrier systems

Table of Contents: “…Contents: Choroid plexus -- Formation of CSF -- Permeability of blood -- CSF barrier vs. blood-brain barrier -- Choroidal secretion of peptides, growth factors and regulatory proteins -- Homeostasis and bulk flow of extracellular fluid in the CNS -- Impact of CSF dynamics on brain metabolism -- Disrupted transport at the blood-CSF interface in hyperthermia, ischemia and Alzheimer's disease -- Reduced CSF reabsorption in aging, hydrocephalus and dementia.…”
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Spindle movement and checkpoint control during mitosis in yeast

Table of Contents: “…Contents: Cell cycle checkpoints for partitioning the genome -- Budding yeast as a model system for the study of genome distribution -- How nuclei are segregated in yeast -- Evidence for a spindle position checkpoint -- Model for checkpoint based on Tem1 -- Movie assay for checkpoint -- Search for upstream inputs -- Screen for checkpoint mutants -- Septins dual role in checkpoint -- Inputs to Lte1 -- Bud6 and microtubule capture -- Potential pathway for Bud6 -- Bud6 and microtubule-binding proteins -- Overexpression analysis -- Inhibition of Lte1 in the cold.…”
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Cell cycle a complex network of signals regulating cell proliferation /

Table of Contents: “…Contents: The cell cycle is a complex system which is highly regulated in a temporal manner, via checkpoints and positive and negative feedback loops -- Two processes must alternate during eukaryotic cell division: S-phase and M-phase entry -- Cell cycle checkpoints -- The cell cycle engine -- Cyclin D-CDK activity -- Not all CDKs and cyclins are involved in the regulation of cell cycle -- Cell cycle and pRb family proteins -- Cell cycle control pathways.…”
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