Search Results - "proteins"

Folding and design of helical repeat proteins

Table of Contents: “…Contents: Repeat proteins versus globular proteins -- Consensus design, the role of conserved hydrophobic residues -- Co-variation can modulate stability, but is not essential to specify a stable fold -- Structure and stability of the designed CTPR proteins -- The thermodynamic behavior of repeat proteins in terms of a 1D Ising model -- Amide H-exchange to study stability on a residue specific basis -- The structure of long TPRs -- Hypervariability defines the ligand binding site: a general result -- Functional TPR designs -- Useful designer proteins -- The awesome power of screens and selections.…”
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Biology and structure of arrestin proteins

Table of Contents: “…Contents: Arrestins -- Arrestin-GPCR binding and signaling -- Nanodiscs -- Arrestin-rhodopsin binding -- Arrestin protein biochemistry -- Physiological effects of mutations.…”
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Lipids, biomembranes and membrane proteins

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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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Quality control of proteins mislocalized to the cytosol

Table of Contents: “…Contents: Protein maturation is monitored for failures -- Failures of protein localization in vitro and in vivo -- Mislocalized proteins are selectively recognized -- Relationship between protein maturation & quality control -- Mitochondrial proteins are also prone to mislocalization -- Recognition of mislocalized mitochondrial proteins -- Protein aggregates can disrupt protein quality control -- Key concepts and the future of protein quality control.…”
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Postsynaptic scaffold proteins in health and disease

Table of Contents: “…Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins.…”
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Proteins that bind methylated DNA

Table of Contents: “…Contents: Introductory notions: distribution, abundance, and consequences of DNA methylation -- The methyl-binding proteins: who they are, how they were found -- What do the methyl-binding proteins do? …”
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How do proteins fold and why?

Table of Contents: “…Contents: Challenges to studying protein folding -- Methods based on hydrogen exchange (HX) -- Foldon units -- Step-wise assembly -- Building the native protein -- Error-dependent misfolding steps -- Role of chaperone molecules -- Other roles for Foldon behavior.…”
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Folding and design of helical repeat proteins

Table of Contents: “…Contents: Repeat proteins versus globular proteins -- Consensus design, the role of conserved hydrophobic residues -- Co-variation can modulate stability, but is not essential to specify a stable fold -- Structure and stability of the designed CTPR proteins -- The thermodynamic behavior of repeat proteins in terms of a 1D Ising model -- Amide H-exchange to study stability on a residue specific basis -- The structure of long TPRs -- Hypervariability defines the ligand binding site: a general result -- Functional TPR designs -- Useful designer proteins -- The awesome power of screens and selections.…”
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How do proteins fold and why?

Table of Contents: “…Contents: Challenges to studying protein folding -- Methods based on hydrogen exchange (HX) -- Foldon units -- Step-wise assembly -- Building the native protein -- Error-dependent misfolding steps -- Role of chaperone molecules -- Other roles for Foldon behavior.…”
Get full text
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Folding and design of helical repeat proteins

Table of Contents: “…Contents: Repeat proteins versus globular proteins -- Consensus design, the role of conserved hydrophobic residues -- Co-variation can modulate stability, but is not essential to specify a stable fold -- Structure and stability of the designed CTPR proteins -- The thermodynamic behavior of repeat proteins in terms of a 1D Ising model -- Amide H-exchange to study stability on a residue specific basis -- The structure of long TPRs -- Hypervariability defines the ligand binding site: a general result -- Functional TPR designs -- Useful designer proteins -- The awesome power of screens and selections.…”
Get full text
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Proteins that bind methylated DNA

Table of Contents: “…Contents: Introductory notions: distribution, abundance, and consequences of DNA methylation -- The methyl-binding proteins: who they are, how they were found -- What do the methyl-binding proteins do? …”
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Postsynaptic scaffold proteins in health and disease

Table of Contents: “…Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins.…”
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Quality control of proteins mislocalized to the cytosol

Table of Contents: “…Contents: Protein maturation is monitored for failures -- Failures of protein localization in vitro and in vivo -- Mislocalized proteins are selectively recognized -- Relationship between protein maturation & quality control -- Mitochondrial proteins are also prone to mislocalization -- Recognition of mislocalized mitochondrial proteins -- Protein aggregates can disrupt protein quality control -- Key concepts and the future of protein quality control.…”
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Lipids, biomembranes and membrane proteins

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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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Biology and structure of arrestin proteins

Table of Contents: “…Contents: Arrestins -- Arrestin-GPCR binding and signaling -- Nanodiscs -- Arrestin-rhodopsin binding -- Arrestin protein biochemistry -- Physiological effects of mutations.…”
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Titin 127 a protein with a complex folding landscape /

Table of Contents: “…Contents: Examination of the folding of titin 127 -- Evolution of the protein to withstand stress from mutation, the environment and to withstand mechanical force in the muscle -- Use of a combination of protein engineering, kinetic and thermodynamic measurements, computer simulations and single molecule atomic force microscopy to understand how evolution acts on protein sequences to allow them to adapt to stressful conditions, probably explaining why immunoglobulin-like proteins are used so successfully in evolution to perform a number of functions.…”
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Heat shock proteins and their role in the immune regulation of inflammation

Table of Contents: “…Contents: Evolutionary conservation of heat shock proteins -- Models of autoimmunity and other inflammatory conditions -- Heat shock proteins induce regulatory T cells -- Heat shock proteins are targets of immunotherapeutic vaccines.…”
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Novel proteins from designed combinatorial libraries

Table of Contents: “…Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.…”
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