Search Results - "proteins"

The choroid in aging and disease

Table of Contents: “…Contents: Age-related Macular Degeneration (AMD) -- Drusen -- Atrophy -- Vascular changes -- Proteomics of choroidal thinning -- Fibrosis -- CD34 -- C-reactive protein accumulation -- Complement cascade: Membrane Attack Complex (MAC).…”
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Mechanisms of RNAi a molecular view or Argonaute : the secret life of slicer /

Table of Contents: “…Contents: Impact of RNAi on biology -- Gene silencing -- Mechanism of unravelling -- Understanding the mechanism of RNAi related pathways -- Transcriptional and post-transcriptional gene silencing -- DNA elimination in tetrahymena -- Mechanistic aspects of RNAi -- The argonaute protein.…”
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Mechanisms of RNAi a molecular view or Argonaute : the secret life of slicer /

Table of Contents: “…Contents: Impact of RNAi on biology -- Gene silencing -- Mechanism of unravelling -- Understanding the mechanism of RNAi related pathways -- Transcriptional and post-transcriptional gene silencing -- DNA elimination in tetrahymena -- Mechanistic aspects of RNAi -- The argonaute protein.…”
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The choroid in aging and disease

Table of Contents: “…Contents: Age-related Macular Degeneration (AMD) -- Drusen -- Atrophy -- Vascular changes -- Proteomics of choroidal thinning -- Fibrosis -- CD34 -- C-reactive protein accumulation -- Complement cascade: Membrane Attack Complex (MAC).…”
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Structure of cell walls in yeast and other fungi

Table of Contents: “…Contents: Fungal cell walls -- Glycans -- S. cerevisiae -- C. albicans -- Mannose -- Chitin -- Glycan biosynthesis -- Mannoproteins -- GPI-crosslinked proteins -- N. crassa -- Yeast cell wall dynamics -- Cell wall conservation and evolution.…”
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ABO blood groups and SARS-CoV-2 susceptibility

Table of Contents: “…Contents: How blood group can affect susceptibility to viruses -- The initial studies into blood group and COVID-19 susceptibility -- Molecular research in this topic -- The possible involvement of the Rhesus (Rh) protein -- Future steps in this field.…”
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Hepatitis C cure of infection /

Table of Contents: “…Contents: HCV: major milestones -- Hepatitis C virus & infection -- Hepatocellular cancer -- HCV natural history and therapy -- HCV RNA and protein -- HCV genotypes and subtypes -- Hepatitis C vaccine -- Direct acting antivirals (DAAs).…”
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Neuropathology of neurodegenerative disorders

Table of Contents: “…Contents: Pathologies seen in neurodegenerative disorders -- Alzheimer's disease -- Frontotemporal dementia -- Amyotrophic lateral sclerosis and Lewy body diseases -- The macroscopic and microscopic features -- The nature and topography of protein deposits -- The pattern and extent of atrophy in neurodegenerative disorders.…”
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Hepatitis C cure of infection /

Table of Contents: “…Contents: HCV: major milestones -- Hepatitis C virus & infection -- Hepatocellular cancer -- HCV natural history and therapy -- HCV RNA and protein -- HCV genotypes and subtypes -- Hepatitis C vaccine -- Direct acting antivirals (DAAs).…”
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Hepatitis C cure of infection /

Table of Contents: “…Contents: HCV: major milestones -- Hepatitis C virus & infection -- Hepatocellular cancer -- HCV natural history and therapy -- HCV RNA and protein -- HCV genotypes and subtypes -- Hepatitis C vaccine -- Direct acting antivirals (DAAs).…”
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Neuropathology of neurodegenerative disorders

Table of Contents: “…Contents: Pathologies seen in neurodegenerative disorders -- Alzheimer's disease -- Frontotemporal dementia -- Amyotrophic lateral sclerosis and Lewy body diseases -- The macroscopic and microscopic features -- The nature and topography of protein deposits -- The pattern and extent of atrophy in neurodegenerative disorders.…”
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Peroxynitrite biochemistry oxidation and nitration reactions

Table of Contents: “…Contents: Nitric oxide reaction with superoxide radical: the formation of peroxynitrite -- Peroxynitrite-mediated thiol oxidation -- Peroxynitrite decomposition pathways: one vs two-electron oxidation processes -- Thyl radicals and sulfenic acids -- Peroxynitrite kinetics and stopped flow analysis -- Peroxynitrite reaction with fact reaction thiols, the case of peroxiredoxins -- Peroxynitrite reaction with transition metals -- The reaction of peroxynitrite with carbon dioxide: the formation of carbonate radicals -- Proton-catalyzed homolysis of peroxynitrite to hydroxyl radicals -- Lipid peroxidation and nitration -- Protein tyrosine nitration, a free radical process -- Protein tyrosine nitration in disease states -- Peroxynitrite and mitochondrial dysfunction -- Role of peroxynitrite in pathology -- Peroxynitrite therapeutics.…”
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Autophagy as a barrier to infection

Table of Contents: “…Contents: Autophagosome biogenesis -- Autophagy a regulated intersection of the secretory and endosomal pathways -- Genetic analysis in yeast has accelerated autophagy research -- Autophagy is inhibited by mTOR -- Autophagosome biogenesis is coordinated by a cascade of Atg proteins -- Autophagosomes mature rapidly in C57Bl/6 macrophages -- A wide variety of pathogens encounter the autophagy pathway -- Autophagy in infection and immunity -- Illustrations: Legionella pneumophila -- Shigella flexnerii -- Crohns' disease -- Mycobacterium tuberculosis -- Naip5 NOD-like receptor cytosolic surveillance protein -- Inflammasome components coordinate autophagy and pyroptosis as barriers to infection -- Autophagy enhances MHCI and MHCII antigen presentation.…”
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Type I interferons in innate immunity to viral infections

Table of Contents: “…Contents: Evolving immune response -- Interferons -- Antiviral effects -- IFNalfa/beta induction -- Role of IFNalfa/beta in fighting off viruses and infection -- Activation of immune response cascades during viral challenges -- Immunoregulation -- NK cells during viral infections -- Innate lymphocytes in defense -- Regulation of NK cell responses by IFNalfa/beta and IL-12 -- IFN signaling -- STAT1 in defense against infection -- Kinetics of cell and cytokine responses to LCMV infections -- STAT expression in NK cells -- Type 1 IFN receptor association -- Gene expression and protein-protein interactions for regulating type 1 IFN effects -- Interferon treatment -- Interferon ablation.…”
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The molecular biology of the inositol trisphosphate receptor

Table of Contents: “…Contents: Activation of the IP3-receptor (IP3R), a major endoplasmic Calcium release channel in many cells, is activated by the second messenger inositol 1,4,5-trisphosphate (IP3) -- The IP3R is unique in that it can integrate signals from numerous cellular pathways via a myriad of inputs which include nucleotide binding, phosphorylation, Calcium binding and protein-protein interactions -- A diverse range of cellular functions are modulated by the IP3R including contraction/excitation, secretion, gene expression, cell cycle, apoptosis and cellular growth -- The nodal properties of the IP3R and the mechanisms by which this occurs.…”
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Plasmid rolling-circle (RC) replication

Table of Contents: “…Contents: Rolling circle replicating (RCR) plasmids -- Functional organization of rolling-circle replicating plasmids -- Model for plasmid rolling-circle replication -- Initiation and termination of replication in plasmids carrying two pT181 dsos -- DNA sequence and structure of the pT181 origin -- Initiator proteins of RCR plasmids -- Comparison of the replication origins of the plasmids of pT181 family -- Rep-DNA specificity -- Role of individual monomers of the Rep protein -- Purification of RepC heterodimers -- PcrA helicase -- Role of PcrA helicase in plasmid RC replication -- Conversion of ss to ds DNA -- Single strand origins of replication -- Lagging-strand replication.…”
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Peroxynitrite biochemistry oxidation and nitration reactions

Table of Contents: “…Contents: Nitric oxide reaction with superoxide radical: the formation of peroxynitrite -- Peroxynitrite-mediated thiol oxidation -- Peroxynitrite decomposition pathways: one vs two-electron oxidation processes -- Thyl radicals and sulfenic acids -- Peroxynitrite kinetics and stopped flow analysis -- Peroxynitrite reaction with fact reaction thiols, the case of peroxiredoxins -- Peroxynitrite reaction with transition metals -- The reaction of peroxynitrite with carbon dioxide: the formation of carbonate radicals -- Proton-catalyzed homolysis of peroxynitrite to hydroxyl radicals -- Lipid peroxidation and nitration -- Protein tyrosine nitration, a free radical process -- Protein tyrosine nitration in disease states -- Peroxynitrite and mitochondrial dysfunction -- Role of peroxynitrite in pathology -- Peroxynitrite therapeutics.…”
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Autophagy as a barrier to infection

Table of Contents: “…Contents: Autophagosome biogenesis -- Autophagy a regulated intersection of the secretory and endosomal pathways -- Genetic analysis in yeast has accelerated autophagy research -- Autophagy is inhibited by mTOR -- Autophagosome biogenesis is coordinated by a cascade of Atg proteins -- Autophagosomes mature rapidly in C57Bl/6 macrophages -- A wide variety of pathogens encounter the autophagy pathway -- Autophagy in infection and immunity -- Illustrations: Legionella pneumophila -- Shigella flexnerii -- Crohns' disease -- Mycobacterium tuberculosis -- Naip5 NOD-like receptor cytosolic surveillance protein -- Inflammasome components coordinate autophagy and pyroptosis as barriers to infection -- Autophagy enhances MHCI and MHCII antigen presentation.…”
Get full text
Series

Type I interferons in innate immunity to viral infections

Table of Contents: “…Contents: Evolving immune response -- Interferons -- Antiviral effects -- IFNalfa/beta induction -- Role of IFNalfa/beta in fighting off viruses and infection -- Activation of immune response cascades during viral challenges -- Immunoregulation -- NK cells during viral infections -- Innate lymphocytes in defense -- Regulation of NK cell responses by IFNalfa/beta and IL-12 -- IFN signaling -- STAT1 in defense against infection -- Kinetics of cell and cytokine responses to LCMV infections -- STAT expression in NK cells -- Type 1 IFN receptor association -- Gene expression and protein-protein interactions for regulating type 1 IFN effects -- Interferon treatment -- Interferon ablation.…”
Get full text
Series

The molecular biology of the inositol trisphosphate receptor

Table of Contents: “…Contents: Activation of the IP3-receptor (IP3R), a major endoplasmic Calcium release channel in many cells, is activated by the second messenger inositol 1,4,5-trisphosphate (IP3) -- The IP3R is unique in that it can integrate signals from numerous cellular pathways via a myriad of inputs which include nucleotide binding, phosphorylation, Calcium binding and protein-protein interactions -- A diverse range of cellular functions are modulated by the IP3R including contraction/excitation, secretion, gene expression, cell cycle, apoptosis and cellular growth -- The nodal properties of the IP3R and the mechanisms by which this occurs.…”
Get full text
Series