Search Results - "proteins"

Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /

Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
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The unfolded protein response

Table of Contents: “…Contents: Molecular mechanism unfolded protein response -- Physiological importance of the unfolded protein response -- Intracellular signaling from the endoplasmic reticulum (ER) to the nucleus -- Reasons for activation -- Maintenance of homeostasis of the ER.…”
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Protein folding in vivo

Table of Contents: “…Contents: Protein folding in vivo -- Protein folding as facilitated by the acid inducible chaperone HdeA -- Optimization of folding in vivo illustrates a tradeoff between stability and function -- The Spy chaperone.…”
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Protein homeostasis in mitochondria AAA+ chaperones & proteases /

Table of Contents: “…Contents: Protein homeostasis in mitochondria -- Mitochondria play an important role in ageing and disease -- Quality control of mitochondria is controlled at three different levels -- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases -- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated -- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling -- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.…”
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Protein-glycan interactions

Table of Contents: “…Contents: NMR studies -- Protein structure -- Protein-protein Interactions -- Building models with a ligand -- Chemokine CCL5 interactions with GAGs -- STD-NOESY -- Residual dipolar coupling (RDC) -- SAXS data -- Cross-saturation -- Radical footprinting -- Glycans on a glycoprotein -- - Preparing IgG with homogeneous 13C glycans -- Relaxation dispersion -- Galactose terminated Fc glycans Locating glycans more precisely -- Sialylated glycans -- CPMG R2 relaxation -- Di-sialylation.…”
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Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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Aging and protein homeostasis

Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
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Protein structure principles

Table of Contents: “…Contents: Primary protein structure -- X-ray diffraction and protein 3D structure -- Interactions within proteins -- Peptide bond constraints -- Ramachandran maps.…”
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Observed protein structures

Table of Contents: “…Contents: Protein secondary structures: alpha helix, beta-sheet, turns, and collagen -- Collagen properties -- The "protein fold" -- Protein arrangement according to type of fold, superfamily and family.…”
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Protein stability and folding

Table of Contents: “…Contents: Protein stability -- Folding and refolding -- Molecular chaperones -- Motions within proteins -- Protein classification by function -- Protein classification by complexity.…”
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Fundamentals of protein chromatography part 1, basic protein purification /

Table of Contents: “…Contents: Protein purification scheme and strategy -- Properties of proteins as handles for fractionation -- Obstacles during protein purifications and solutions -- Suitable buffers and practices to stabilize proteins.…”
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Fundamentals of protein chromatography part 2, protein chromatography /

Table of Contents: “…Contents: History of chromatography -- Forces and properties of proteins as handles for fractionation -- Types of chromatography -- Chromatography components -- HPLC -- Trouble shooting some chromatography problems -- Protein purification for pharmaceutical applications.…”
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Understanding protein variability through functional analysis of random mutagenesis

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V-Myb proteins and their oncogenic potential a study on how two point mutations affect the interaction of v-Myb with other proteins / by Wienert, Beeke

Subjects: “…Protein-protein interactions.…”
An electronic book accessible through the World Wide Web; click to view

The periplasm

Subjects: “…Bacterial proteins.…”
An electronic book accessible through the World Wide Web; click to view

Protein analysis using mass spectrometry : accelerating protein biotherapeutics from lab to patient /

Subjects: “…Proteins Analysis.…”
An electronic book accessible through the World Wide Web; click to view

Quality control of proteins mislocalized to the cytosol

Table of Contents: “…Contents: Protein maturation is monitored for failures -- Failures of protein localization in vitro and in vivo -- Mislocalized proteins are selectively recognized -- Relationship between protein maturation & quality control -- Mitochondrial proteins are also prone to mislocalization -- Recognition of mislocalized mitochondrial proteins -- Protein aggregates can disrupt protein quality control -- Key concepts and the future of protein quality control.…”
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Postsynaptic scaffold proteins in health and disease

Table of Contents: “…Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins.…”
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Proteins that bind methylated DNA

Table of Contents: “…Contents: Introductory notions: distribution, abundance, and consequences of DNA methylation -- The methyl-binding proteins: who they are, how they were found -- What do the methyl-binding proteins do? …”
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How do proteins fold and why?

Table of Contents: “…Contents: Challenges to studying protein folding -- Methods based on hydrogen exchange (HX) -- Foldon units -- Step-wise assembly -- Building the native protein -- Error-dependent misfolding steps -- Role of chaperone molecules -- Other roles for Foldon behavior.…”
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