Search Results - "proteins"

Mapping small molecule binding sites with phage display technology

Table of Contents: “…-- Flexible regions are key players -- P-loop of ATP-binding proteins is an important example -- Can display libraries of flexible peptides on proteins select those that bind to the ligand -- Selection is through an affinity process called biopanning -- Success depends on the diversity of the library -- Diversity depends on how many different peptides are in the library and their relative abundance -- RELIC can be used to calculate the diversity of a library from the sequences of ~100 peptides -- Identification of motifs from a population is easy if the motif is very strong -- Taxol-binding peptides were also identified by phage display and those peptides were used to identify the position on tubulin where taxol is bound and to identify Bcl-2 as a taxolbinding protein -- Significant data from a variety of sources argue that the taxol-Bcl-2 interaction is important to the clinical efficacy of taxol.…”
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Advances in chromatography.

Taylor & Francis
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Mapping small molecule binding sites with phage display technology

Table of Contents: “…-- Flexible regions are key players -- P-loop of ATP-binding proteins is an important example -- Can display libraries of flexible peptides on proteins select those that bind to the ligand -- Selection is through an affinity process called biopanning -- Success depends on the diversity of the library -- Diversity depends on how many different peptides are in the library and their relative abundance -- RELIC can be used to calculate the diversity of a library from the sequences of ~100 peptides -- Identification of motifs from a population is easy if the motif is very strong -- Taxol-binding peptides were also identified by phage display and those peptides were used to identify the position on tubulin where taxol is bound and to identify Bcl-2 as a taxolbinding protein -- Significant data from a variety of sources argue that the taxol-Bcl-2 interaction is important to the clinical efficacy of taxol.…”
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Mapping small molecule binding sites with phage display technology

Table of Contents: “…-- Flexible regions are key players -- P-loop of ATP-binding proteins is an important example -- Can display libraries of flexible peptides on proteins select those that bind to the ligand -- Selection is through an affinity process called biopanning -- Success depends on the diversity of the library -- Diversity depends on how many different peptides are in the library and their relative abundance -- RELIC can be used to calculate the diversity of a library from the sequences of ~100 peptides -- Identification of motifs from a population is easy if the motif is very strong -- Taxol-binding peptides were also identified by phage display and those peptides were used to identify the position on tubulin where taxol is bound and to identify Bcl-2 as a taxolbinding protein -- Significant data from a variety of sources argue that the taxol-Bcl-2 interaction is important to the clinical efficacy of taxol.…”
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Wetware a computer in every living cell / by Bray, Dennis

Table of Contents: “…Clever cells -- Simulated life -- Protein switches -- Protein signals -- Cell wiring -- Neural nets -- Cell awareness -- Molecular morphing -- Cells together -- Genetic circuits -- Robots -- The juice -- Amoeba redux.…”
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Metals, oxidative stress and neurodegeneration

Table of Contents: “…Contents: Production of reactive oxygen species (ROS) -- Chemical origin -- Generic mechanism of protein and transition metal combination -- Pathological protein aggregates -- Toxic ROS generation -- Role in etiology and tissue specificity of agedependent neurodegenerative diseases.…”
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Metals, oxidative stress and neurodegeneration

Table of Contents: “…Contents: Production of reactive oxygen species (ROS) -- Chemical origin -- Generic mechanism of protein and transition metal combination -- Pathological protein aggregates -- Toxic ROS generation -- Role in etiology and tissue specificity of agedependent neurodegenerative diseases.…”
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Metals, oxidative stress and neurodegeneration

Table of Contents: “…Contents: Production of reactive oxygen species (ROS) -- Chemical origin -- Generic mechanism of protein and transition metal combination -- Pathological protein aggregates -- Toxic ROS generation -- Role in etiology and tissue specificity of agedependent neurodegenerative diseases.…”
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Pattern discovery in bioinformatics

Table of Contents: “…-- Sequence patterns: representations and protein sequence -- Patterns of DNA-protein interactions -- Structure patterns: representations, discovery and applications -- Sequence-structure patterns -- Designing training sets for supervised discovery -- Algorithmic techniques.…”
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Pattern discovery in bioinformatics

Table of Contents: “…-- Sequence patterns: representations and protein sequence -- Patterns of DNA-protein interactions -- Structure patterns: representations, discovery and applications -- Sequence-structure patterns -- Designing training sets for supervised discovery -- Algorithmic techniques.…”
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Pattern discovery in bioinformatics

Table of Contents: “…-- Sequence patterns: representations and protein sequence -- Patterns of DNA-protein interactions -- Structure patterns: representations, discovery and applications -- Sequence-structure patterns -- Designing training sets for supervised discovery -- Algorithmic techniques.…”
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Microbial Cell Factories

Open Access

Microbial Cell Factories

Open Access

The development and function of vertebrate cilia

Table of Contents: “…Contents: Motile and primary cilia -- Developmental regulation of ciliogenesis -- Role of the Roxj1 transcription factor in motile cilia formation -- Hedgehog signaling and primary cilia -- DZIP1 proteins in ciliary biogenesis.…”
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Pharmaceutical Biocatalysis : Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases /

Taylor & Francis
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Overview of eukaryotic molecular chaperones in the cytosol

Table of Contents: “…Contents: Protein folding and molecular chaperones -- Hsp70/Hsc70 -- Co-chaperones of Hsc70 -- Chaperonin TRiC/CCT -- Prefoldin -- Hsp90 -- Co-chaperones of Hsp90 -- Specialized co-chaperones -- Heat shock protein chaperones.…”
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Mitochondrial permeability transition

Table of Contents: “…Contents: Factors regulating opening of permeability transition pores -- Models of permeability transition pore composition -- Discrepancies of consensus model -- Protein misfolding and the MPT -- Rieske iron sulfur protein -- Reye's syndrome -- Ischemia/reperfusion and oxidative stress -- Apoptosis -- Mitochondrial autophagy (mitophagy) -- Necrapoptosis.…”
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Mitochondrial permeability transition

Table of Contents: “…Contents: Factors regulating opening of permeability transition pores -- Models of permeability transition pore composition -- Discrepancies of consensus model -- Protein misfolding and the MPT -- Rieske iron sulfur protein -- Reye's syndrome -- Ischemia/reperfusion and oxidative stress -- Apoptosis -- Mitochondrial autophagy (mitophagy) -- Necrapoptosis.…”
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Mitochondrial permeability transition

Table of Contents: “…Contents: Factors regulating opening of permeability transition pores -- Models of permeability transition pore composition -- Discrepancies of consensus model -- Protein misfolding and the MPT -- Rieske iron sulfur protein -- Reye's syndrome -- Ischemia/reperfusion and oxidative stress -- Apoptosis -- Mitochondrial autophagy (mitophagy) -- Necrapoptosis.…”
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The SODs

Table of Contents: “…Contents: Superoxide dismutase -- Eukaryotic cell SODs -- Copper-Zinc Superoxide Dismutase (CuZnSOD) protein -- CuZnSOD activity -- CuZnSOD transcripts -- The CuZnSOD gene -- Manganese Superoxide Dismutase (MnSOD) protein -- MnSOD transcripts -- The MnSOD gene -- MnSOD function -- Extracellular Superoxide Dismutase (ECSOD) protein -- ECSOD activity -- ECSOD transcripts -- The ECSOD gene -- SODs modulate redox signaling? …”
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