Search Results - "proteins"

History and geography of human genetic diversity I

Table of Contents: “…Contents: Four major factors of evolution: mutation, natural selection, drift, migration -- Role of demography in the quantitative study of evolution -- Drift: the Parma Valley study -- Equilibrium of migration and drift -- Founders' effect -- Reconstructing evolutionary history of a population -- Evidence of the importance of drift from molecular evolution -- Molecular evolution of proteins -- Trees with proteins and trees with DNA -- Phylogeographic analysis -- Microsatellites -- Graphic presentation of evolution data by principal components analysis.…”
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History and geography of human genetic diversity I

Table of Contents: “…Contents: Four major factors of evolution: mutation, natural selection, drift, migration -- Role of demography in the quantitative study of evolution -- Drift: the Parma Valley study -- Equilibrium of migration and drift -- Founders' effect -- Reconstructing evolutionary history of a population -- Evidence of the importance of drift from molecular evolution -- Molecular evolution of proteins -- Trees with proteins and trees with DNA -- Phylogeographic analysis -- Microsatellites -- Graphic presentation of evolution data by principal components analysis.…”
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Hepatitis C and HCV

Table of Contents: “…Contents: The spectrum of hepatitis viruses -- Global distribution of HCV infection -- Associated diseases -- Hepatitis C pathogenesis -- HCV model systems -- Replication of HCV RNA -- Hypothetical membrane topology of HCV proteins -- HCV structural proteins -- p7 protein -- Hepatitis C virus life cycle -- Polyprotein functions in the viral life cycle -- Subgenomic HCV replicon life cycle -- The central issue in hepatitis C is viral persistence -- Possible mechanisms of HCV persistence.…”
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Historical introduction to human diversity II

Table of Contents: “…Contents: Electrophoresis -- Electrophoretic mobility -- Amino acids -- Specific detection methods -- Detecting protein size differences -- Ioselectric focusing -- Protein polymorphism -- DNA polymorphism and electrophoresis -- Tandem repeats -- Genotype and phenotype -- Epistasis -- Isozymes -- Many proteins are encoded by multiple genes -- Multimeric proteins -- How do we know that a protein is encoded by multiple genes/alleles? …”
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History and geography of human genetic diversity I

Table of Contents: “…Contents: Four major factors of evolution: mutation, natural selection, drift, migration -- Role of demography in the quantitative study of evolution -- Drift: the Parma Valley study -- Equilibrium of migration and drift -- Founders' effect -- Reconstructing evolutionary history of a population -- Evidence of the importance of drift from molecular evolution -- Molecular evolution of proteins -- Trees with proteins and trees with DNA -- Phylogeographic analysis -- Microsatellites -- Graphic presentation of evolution data by principal components analysis.…”
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Hepatitis C and HCV

Table of Contents: “…Contents: The spectrum of hepatitis viruses -- Global distribution of HCV infection -- Associated diseases -- Hepatitis C pathogenesis -- HCV model systems -- Replication of HCV RNA -- Hypothetical membrane topology of HCV proteins -- HCV structural proteins -- p7 protein -- Hepatitis C virus life cycle -- Polyprotein functions in the viral life cycle -- Subgenomic HCV replicon life cycle -- The central issue in hepatitis C is viral persistence -- Possible mechanisms of HCV persistence.…”
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Historical introduction to human diversity II

Table of Contents: “…Contents: Electrophoresis -- Electrophoretic mobility -- Amino acids -- Specific detection methods -- Detecting protein size differences -- Ioselectric focusing -- Protein polymorphism -- DNA polymorphism and electrophoresis -- Tandem repeats -- Genotype and phenotype -- Epistasis -- Isozymes -- Many proteins are encoded by multiple genes -- Multimeric proteins -- How do we know that a protein is encoded by multiple genes/alleles? …”
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Covalently constrained alpha-helices

Table of Contents: “…Contents: Alpha-helices -- Role of alpha-helices in protein structure -- Alpha-helices in protein-protein and protein-nucleic acids interactions -- Stabilization of short peptides in alpha-helical conformation -- Side-chain cross-linked helices -- Hydrogen-bond surrogate based alpha-helices.…”
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Covalently constrained alpha-helices

Table of Contents: “…Contents: Alpha-helices -- Role of alpha-helices in protein structure -- Alpha-helices in protein-protein and protein-nucleic acids interactions -- Stabilization of short peptides in alpha-helical conformation -- Side-chain cross-linked helices -- Hydrogen-bond surrogate based alpha-helices.…”
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Covalently constrained alpha-helices

Table of Contents: “…Contents: Alpha-helices -- Role of alpha-helices in protein structure -- Alpha-helices in protein-protein and protein-nucleic acids interactions -- Stabilization of short peptides in alpha-helical conformation -- Side-chain cross-linked helices -- Hydrogen-bond surrogate based alpha-helices.…”
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The endoplasmic reticulum in plants

Table of Contents: “…Contents: The secretory pathway in plants -- The endoplasmic reticulum is the entry point into the secretory pathway -- Protein entry in the ER -- Protein synthesis on the rough endoplasmic reticulum -- Protein folding -- Protein export from the ER -- Export from the ER to the Golgi -- Retrograde transport from the Golgi -- Techniques to study the plant ER.…”
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The endoplasmic reticulum in plants

Table of Contents: “…Contents: The secretory pathway in plants -- The endoplasmic reticulum is the entry point into the secretory pathway -- Protein entry in the ER -- Protein synthesis on the rough endoplasmic reticulum -- Protein folding -- Protein export from the ER -- Export from the ER to the Golgi -- Retrograde transport from the Golgi -- Techniques to study the plant ER.…”
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The endoplasmic reticulum in plants

Table of Contents: “…Contents: The secretory pathway in plants -- The endoplasmic reticulum is the entry point into the secretory pathway -- Protein entry in the ER -- Protein synthesis on the rough endoplasmic reticulum -- Protein folding -- Protein export from the ER -- Export from the ER to the Golgi -- Retrograde transport from the Golgi -- Techniques to study the plant ER.…”
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The functions of the Hsp70 system

Table of Contents: “…Contents: Early steps and problems in nascent protein folding -- Molecular chaperones prevent protein aggregation -- Heat shock protein (molecular chaperone) classes -- Hsp70: characteristics and mechanism of action -- Hsp70 function and cancer (prevention of apoptosis) -- Hsp70 function and viral replication (the polyomaviruses) -- Hsp70 function and protein conformational diseases (ERAD).…”
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The chloroplast proteome

Table of Contents: “…Contents: What is proteomics and what does it measure? -- Protein identification by mass spectrometry -- The problem of complex mixtures and protein identification -- Quantitative proteomics and stable isotope labeling -- Intact protein mass measurements and top-down proteomics.…”
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NK cell signaling to cytotoxicity part 1 /

Table of Contents: “…Contents: NK cell cytotoxicity -- Introduction to NK cell activating receptors -- Regulation of NK cell cytotoxicity by immunoreceptor tyrosine-based activation motif associated receptors -- The downstream targets regulating NK cytolytic activity -- PI3K pathway is required for the development of cellular cytotoxicity -- LAT/NTAL are required for DAP12-initiated cytotoxicity and production of interferon gamma -- PLCγ2 is required for NK cell killing -- Vav proteins are linked to NK cell activating receptors and regulate the development of cellular cytotoxicity -- Rho family GTP-binding proteins regulate NK cell-mediated cytotoxicity.…”
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Blood brain barrier in health and disease

Table of Contents: “…Contents: The blood-brain barrier is not a static barrier -- The blood-brain barrier does inhibit drug delivery to the brain -- The blood-brain barrier is at the level of the endothelial cell cytoarchitecture that line all cerebral blood vessels in the brain -- The blood-brain barrier consists of a unique set of regulated proteins held together in a tight cytoarchitectural matrix to form a tight junction -- Stressors such as head injury, hypoxia, pain and diseases such as M.S, diabetes, Alzheimer's, cancer and stroke alter tight junction proteins of the blood-brain barrier leading to a "leak" and a loss of integrity -- Understanding what controls the integrity of the blood-brain barrier is critical if we are to understand how to treat the diseases of the brain.…”
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NK cell signaling to cytotoxicity part 1 /

Table of Contents: “…Contents: NK cell cytotoxicity -- Introduction to NK cell activating receptors -- Regulation of NK cell cytotoxicity by immunoreceptor tyrosine-based activation motif associated receptors -- The downstream targets regulating NK cytolytic activity -- PI3K pathway is required for the development of cellular cytotoxicity -- LAT/NTAL are required for DAP12-initiated cytotoxicity and production of interferon gamma -- PLCγ2 is required for NK cell killing -- Vav proteins are linked to NK cell activating receptors and regulate the development of cellular cytotoxicity -- Rho family GTP-binding proteins regulate NK cell-mediated cytotoxicity.…”
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NK cell signaling to cytotoxicity part 1 /

Table of Contents: “…Contents: NK cell cytotoxicity -- Introduction to NK cell activating receptors -- Regulation of NK cell cytotoxicity by immunoreceptor tyrosine-based activation motif associated receptors -- The downstream targets regulating NK cytolytic activity -- PI3K pathway is required for the development of cellular cytotoxicity -- LAT/NTAL are required for DAP12-initiated cytotoxicity and production of interferon gamma -- PLCγ2 is required for NK cell killing -- Vav proteins are linked to NK cell activating receptors and regulate the development of cellular cytotoxicity -- Rho family GTP-binding proteins regulate NK cell-mediated cytotoxicity.…”
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Calcium, calmodulin and calcineurin

Table of Contents: “…Contents: Calmodulin is highly conserved -- Calmodulin structure -- EF hand proteins -- Calcium binding -- Calmodulin targets -- Mechanism of calmodulin action -- Calmodulin-dependent protein kinases -- Calmodulin dependent protein kinase II autonomy -- Calcineurin structure and activation -- Action of cyclosporin -- NFAT signaling -- Phosphatases downstream of calcineurin -- Differential responses of calmodulin-dependent protein kinase II and calcineurin to calcium signals.…”
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