Search Results - "proteins"

The plasma membrane calcium pump biochemistry, physiology and molecular pathology /

Table of Contents: “…Contents: Targets of the signaling function of calcium -- Decoding of the calcium message by specific calcium binding proteins -- Control of calcium in the cell by calcium transporting proteins in the membranes -- Calcium pumps: biochemistry, molecular biology, structure and regulation -- Similarities in the regulation mechanisms between the two major pumps, that in the endoplasmic reticulum and that in the plasma membrane -- Ambivalence of the calcium signal -- Calcium signaling defects and related pathologies -- Genetic defects of the plasma membrane calcium pumps in hereditary deafness.…”
Get full text
Series

Possible roles of mitochondrial biogenesis in aging

Table of Contents: “…Contents: Oxidative phosphorylation -- The mitochondrial DNA -- Aging as the accumulation of damage -- Types of aging damage -- Types of damaged cells -- Survival of cells lacking oxidative phosphorylation -- The plasma membrane redox system -- Reductive hotspot hypothesis -- "Survival of the slowest" hypothesis -- Allotopic expression -- Hydrophobicity prevents allotopic expression of mitochondrially-encoded proteins -- Ways to make these proteins allotopically expressible.…”
Get full text
Series

Glycoprotein maturation and quality control in the endoplasmic reticulum

Table of Contents: “…Contents: Protein maturation in the secretory pathway -- ER glycoforms -- The glyco-code of the ER -- Calnexin and calreticulin -- Cotranslational folding -- Influenza hemagglutinin -- Oxidation of HA -- HA truncations -- Type I membrane proteins -- Disease states involving ER folding and quality control -- Structural determinants that cause retention -- ER retention signals -- Calnexin binding cycle -- GT or UDP glucose glycoprotein: glycosyltransferase -- Degradation of misfolded proteins -- Carbohydrate trimming -- EDEM1 functions.…”
Get full text
Series

MicroRNA biogenesis

Table of Contents: “…Contents: Definition of microRNA -- Comparison to small interfering RNA -- Mechanism of gene silencing -- Factors in the microRNA pathway -- RNase III proteins and their interacting proteins -- MicroRNA gene structure and transcription -- Drosha and primary microRNA processing -- Exportin 5 and pre-microRNA export -- Dicer and pre-microRNA processing -- RISC assembly and strand selection -- MicroRNA biogenesis in plants -- Experimental tools to investigate microRNA.…”
Get full text
Series

Possible roles of mitochondrial biogenesis in aging

Table of Contents: “…Contents: Oxidative phosphorylation -- The mitochondrial DNA -- Aging as the accumulation of damage -- Types of aging damage -- Types of damaged cells -- Survival of cells lacking oxidative phosphorylation -- The plasma membrane redox system -- Reductive hotspot hypothesis -- "Survival of the slowest" hypothesis -- Allotopic expression -- Hydrophobicity prevents allotopic expression of mitochondrially-encoded proteins -- Ways to make these proteins allotopically expressible.…”
Get full text
Series

Glycoprotein maturation and quality control in the endoplasmic reticulum

Table of Contents: “…Contents: Protein maturation in the secretory pathway -- ER glycoforms -- The glyco-code of the ER -- Calnexin and calreticulin -- Cotranslational folding -- Influenza hemagglutinin -- Oxidation of HA -- HA truncations -- Type I membrane proteins -- Disease states involving ER folding and quality control -- Structural determinants that cause retention -- ER retention signals -- Calnexin binding cycle -- GT or UDP glucose glycoprotein: glycosyltransferase -- Degradation of misfolded proteins -- Carbohydrate trimming -- EDEM1 functions.…”
Get full text
Series

MicroRNA biogenesis

Table of Contents: “…Contents: Definition of microRNA -- Comparison to small interfering RNA -- Mechanism of gene silencing -- Factors in the microRNA pathway -- RNase III proteins and their interacting proteins -- MicroRNA gene structure and transcription -- Drosha and primary microRNA processing -- Exportin 5 and pre-microRNA export -- Dicer and pre-microRNA processing -- RISC assembly and strand selection -- MicroRNA biogenesis in plants -- Experimental tools to investigate microRNA.…”
Get full text
Series

Possible roles of mitochondrial biogenesis in aging

Table of Contents: “…Contents: Oxidative phosphorylation -- The mitochondrial DNA -- Aging as the accumulation of damage -- Types of aging damage -- Types of damaged cells -- Survival of cells lacking oxidative phosphorylation -- The plasma membrane redox system -- Reductive hotspot hypothesis -- "Survival of the slowest" hypothesis -- Allotopic expression -- Hydrophobicity prevents allotopic expression of mitochondrially-encoded proteins -- Ways to make these proteins allotopically expressible.…”
Get full text
Series

Glycoprotein maturation and quality control in the endoplasmic reticulum

Table of Contents: “…Contents: Protein maturation in the secretory pathway -- ER glycoforms -- The glyco-code of the ER -- Calnexin and calreticulin -- Cotranslational folding -- Influenza hemagglutinin -- Oxidation of HA -- HA truncations -- Type I membrane proteins -- Disease states involving ER folding and quality control -- Structural determinants that cause retention -- ER retention signals -- Calnexin binding cycle -- GT or UDP glucose glycoprotein: glycosyltransferase -- Degradation of misfolded proteins -- Carbohydrate trimming -- EDEM1 functions.…”
Get full text
Series

Hepatitis C and HCV

Table of Contents: “…Contents: The spectrum of hepatitis viruses -- Global distribution of HCV infection -- Associated diseases -- Hepatitis C pathogenesis -- HCV model systems -- Replication of HCV RNA -- Hypothetical membrane topology of HCV proteins -- HCV structural proteins -- p7 protein -- Hepatitis C virus life cycle -- Polyprotein functions in the viral life cycle -- Subgenomic HCV replicon life cycle -- The central issue in hepatitis C is viral persistence -- Possible mechanisms of HCV persistence.…”
Get full text
Series

Towards a unifying mechanism for the Hsp70 chaperones

Table of Contents: “…Contents: Hsp70s are conserved molecular chaperones -- They can prevent protein aggregation, they actively unfold and solubilize aggregates and pull translocating proteins across membranes -- A unifying mechanism has been proposed whereby Hsp70 uses the energy of ATP hydrolysis to recruit a force of entropic origin to locally unfold aggregates or pull proteins across membranes -- Entropic pulling is a simple mechanism, reconciling earlier conflicting data -- This provides a framework for curing therapies of protein misfolding diseases -- Alzheimer's disease and aging…”
Get full text
Series

Historical introduction to human diversity II

Table of Contents: “…Contents: Electrophoresis -- Electrophoretic mobility -- Amino acids -- Specific detection methods -- Detecting protein size differences -- Ioselectric focusing -- Protein polymorphism -- DNA polymorphism and electrophoresis -- Tandem repeats -- Genotype and phenotype -- Epistasis -- Isozymes -- Many proteins are encoded by multiple genes -- Multimeric proteins -- How do we know that a protein is encoded by multiple genes/alleles? …”
Get full text
Series

The airway smooth muscle in asthma

Table of Contents: “…Contents: Remodelling of the Asthmatic airway -- Airway smooth muscle (ASM) -- increased deposition of matrix proteins -- Asthma increases ASM -- Characteristics of ASM cells in non-asthmatics -- Characteristics of ASM in asthmatics -- ASM produces extracellular matrix (ECM) proteins -- Differences in ECM in asthmatics -- Fibulin-1 in asthma -- Fibulin as a therapeutic target.…”
Get full text
Series

The plasma membrane calcium pump biochemistry, physiology and molecular pathology /

Table of Contents: “…Contents: Targets of the signaling function of calcium -- Decoding of the calcium message by specific calcium binding proteins -- Control of calcium in the cell by calcium transporting proteins in the membranes -- Calcium pumps: biochemistry, molecular biology, structure and regulation -- Similarities in the regulation mechanisms between the two major pumps, that in the endoplasmic reticulum and that in the plasma membrane -- Ambivalence of the calcium signal -- Calcium signaling defects and related pathologies -- Genetic defects of the plasma membrane calcium pumps in hereditary deafness.…”
Get full text
Series

Towards a unifying mechanism for the Hsp70 chaperones

Table of Contents: “…Contents: Hsp70s are conserved molecular chaperones -- They can prevent protein aggregation, they actively unfold and solubilize aggregates and pull translocating proteins across membranes -- A unifying mechanism has been proposed whereby Hsp70 uses the energy of ATP hydrolysis to recruit a force of entropic origin to locally unfold aggregates or pull proteins across membranes -- Entropic pulling is a simple mechanism, reconciling earlier conflicting data -- This provides a framework for curing therapies of protein misfolding diseases -- Alzheimer's disease and aging…”
Get full text
Series

The plasma membrane calcium pump biochemistry, physiology and molecular pathology /

Table of Contents: “…Contents: Targets of the signaling function of calcium -- Decoding of the calcium message by specific calcium binding proteins -- Control of calcium in the cell by calcium transporting proteins in the membranes -- Calcium pumps: biochemistry, molecular biology, structure and regulation -- Similarities in the regulation mechanisms between the two major pumps, that in the endoplasmic reticulum and that in the plasma membrane -- Ambivalence of the calcium signal -- Calcium signaling defects and related pathologies -- Genetic defects of the plasma membrane calcium pumps in hereditary deafness.…”
Get full text
Series

Towards a unifying mechanism for the Hsp70 chaperones

Table of Contents: “…Contents: Hsp70s are conserved molecular chaperones -- They can prevent protein aggregation, they actively unfold and solubilize aggregates and pull translocating proteins across membranes -- A unifying mechanism has been proposed whereby Hsp70 uses the energy of ATP hydrolysis to recruit a force of entropic origin to locally unfold aggregates or pull proteins across membranes -- Entropic pulling is a simple mechanism, reconciling earlier conflicting data -- This provides a framework for curing therapies of protein misfolding diseases -- Alzheimer's disease and aging…”
Get full text
Series

The airway smooth muscle in asthma

Table of Contents: “…Contents: Remodelling of the Asthmatic airway -- Airway smooth muscle (ASM) -- increased deposition of matrix proteins -- Asthma increases ASM -- Characteristics of ASM cells in non-asthmatics -- Characteristics of ASM in asthmatics -- ASM produces extracellular matrix (ECM) proteins -- Differences in ECM in asthmatics -- Fibulin-1 in asthma -- Fibulin as a therapeutic target.…”
Get full text
Series

Journal of Neuroinflammation

Open Access

Journal of Neuroinflammation

Open Access