Search Results - "proteins"

PI 3-kinases and lipid messengers

Table of Contents: “…Contents: Phosphoinositide lipids and their metabolism -- Lipid second messengers produced by PI 3-kinases (PI3Ks) -- PI3K lipids transduce signals via binding to lipid-binding modules in proteins -- Multiple PI3K isoforms with specific biological functions in mammals -- Aberrant PI3K activation in cancer, overgrowth and immunity -- Clinical trials with PI3K pathway inhibitors -- Approval and Challenges for PI3K inhibitors in cancer treatment.…”
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VEGF inhibitors for anti-angiogenic therapy

“…Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease.…”
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PI 3-kinases and lipid messengers

Table of Contents: “…Contents: Phosphoinositide lipids and their metabolism -- Lipid second messengers produced by PI 3-kinases (PI3Ks) -- PI3K lipids transduce signals via binding to lipid-binding modules in proteins -- Multiple PI3K isoforms with specific biological functions in mammals -- Aberrant PI3K activation in cancer, overgrowth and immunity -- Clinical trials with PI3K pathway inhibitors -- Approval and Challenges for PI3K inhibitors in cancer treatment.…”
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VEGF inhibitors for anti-angiogenic therapy

“…Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease.…”
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Trypsin structure, biosynthesis and functions /

“…Protein biochemistry, synthesis, structure, and cellular functions…”
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Arginine amino acid

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The Bcl-2 family

Table of Contents: “…Contents: Apoptosis -- Discovery of Bcl-2 -- Cell death in worms -- Evolutionarily conserved pathways to cell death -- How cell death initiates -- BH3-only proteins -- Control of BH3- only proteins -- Promiscuous and selective BH3-only proteins -- Diverse Bcl-2 prosurvival proteins must be neutralized for apoptosis -- Pro-survival Bcl-2 proteins restrain Bax and Bak -- Apoptosis in the absence of "activator" BH3-only proteins -- BH3-only proteins activate Bax and Bak indirectly -- Control of Bak -- Outstanding questions.…”
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The Bcl-2 family

Table of Contents: “…Contents: Apoptosis -- Discovery of Bcl-2 -- Cell death in worms -- Evolutionarily conserved pathways to cell death -- How cell death initiates -- BH3-only proteins -- Control of BH3- only proteins -- Promiscuous and selective BH3-only proteins -- Diverse Bcl-2 prosurvival proteins must be neutralized for apoptosis -- Pro-survival Bcl-2 proteins restrain Bax and Bak -- Apoptosis in the absence of "activator" BH3-only proteins -- BH3-only proteins activate Bax and Bak indirectly -- Control of Bak -- Outstanding questions.…”
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The Bcl-2 family

Table of Contents: “…Contents: Apoptosis -- Discovery of Bcl-2 -- Cell death in worms -- Evolutionarily conserved pathways to cell death -- How cell death initiates -- BH3-only proteins -- Control of BH3- only proteins -- Promiscuous and selective BH3-only proteins -- Diverse Bcl-2 prosurvival proteins must be neutralized for apoptosis -- Pro-survival Bcl-2 proteins restrain Bax and Bak -- Apoptosis in the absence of "activator" BH3-only proteins -- BH3-only proteins activate Bax and Bak indirectly -- Control of Bak -- Outstanding questions.…”
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Drug-drug interactions for therapeutic biologics

Table of Contents: “…Drug interactions for therapeutic proteins : a journey just beginning / Honghui Zhou, Bernd Meibohm -- Pharmacokinetic and pharmacodynamic-based drug interactions for therapeutic proteins / Dan Lu ... …”
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Initiation of DNA replication

Table of Contents: “…Contents: Cell cycle control of DNA replication -- Yeast as a model eukaryote -- Control of S-phase entry in yeast -- Characterization of origins of DNA replication -- Modular structure of S. cerevisiae origins -- The budding yeast origin recognition complex (ORC) -- Structure of the ORC-Cdc6 complex -- Evolutionary comparison of ORC AAA+ subunits -- Proteins required for formation of the pre-Replication Complex (pre-RC) -- Cell cycle dependent association of yeast initiation proteins with chromatin -- ATP-dependent assembly of a pre-RC -- Cell cycle regulation of the pre-RC -- The chromosome cycle and establishment of pre-RCs -- Dynamic assembly and stability of ORC in human cells -- Commitment to S-phase and initiation -- Cdc45p is associated with chromatin in a cell cycle-dependent manner -- Temporal regulation of DNA replication -- Dynamics of pre-RC proteins in human cells differ from pre-RC proteins in yeast.…”
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Initiation of DNA replication

Table of Contents: “…Contents: Cell cycle control of DNA replication -- Yeast as a model eukaryote -- Control of S-phase entry in yeast -- Characterization of origins of DNA replication -- Modular structure of S. cerevisiae origins -- The budding yeast origin recognition complex (ORC) -- Structure of the ORC-Cdc6 complex -- Evolutionary comparison of ORC AAA+ subunits -- Proteins required for formation of the pre-Replication Complex (pre-RC) -- Cell cycle dependent association of yeast initiation proteins with chromatin -- ATP-dependent assembly of a pre-RC -- Cell cycle regulation of the pre-RC -- The chromosome cycle and establishment of pre-RCs -- Dynamic assembly and stability of ORC in human cells -- Commitment to S-phase and initiation -- Cdc45p is associated with chromatin in a cell cycle-dependent manner -- Temporal regulation of DNA replication -- Dynamics of pre-RC proteins in human cells differ from pre-RC proteins in yeast.…”
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Initiation of DNA replication

Table of Contents: “…Contents: Cell cycle control of DNA replication -- Yeast as a model eukaryote -- Control of S-phase entry in yeast -- Characterization of origins of DNA replication -- Modular structure of S. cerevisiae origins -- The budding yeast origin recognition complex (ORC) -- Structure of the ORC-Cdc6 complex -- Evolutionary comparison of ORC AAA+ subunits -- Proteins required for formation of the pre-Replication Complex (pre-RC) -- Cell cycle dependent association of yeast initiation proteins with chromatin -- ATP-dependent assembly of a pre-RC -- Cell cycle regulation of the pre-RC -- The chromosome cycle and establishment of pre-RCs -- Dynamic assembly and stability of ORC in human cells -- Commitment to S-phase and initiation -- Cdc45p is associated with chromatin in a cell cycle-dependent manner -- Temporal regulation of DNA replication -- Dynamics of pre-RC proteins in human cells differ from pre-RC proteins in yeast.…”
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Molecular pathogenesis and prevention of Staphylococcus aureus infections

Table of Contents: “…Contents: The envelope of gram-positive bacteria -- Anchoring proteins -- Signal peptides of staphylococcal surface proteins -- Protein traffic to the cell wall envelope of S. aureus -- Fate of S. aureus injected into mice bloodstream -- Abscess formation -- What are the protective antigens of staphylococci? …”
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HIV peculiarities of its genome /

Table of Contents: “…Contents: Molecular organization of HIV -- HIV-1 mRNAs -- Env and HIV-1 entry -- Tat and Rev are essential RNA binding HIV-1 proteins -- HIV-1 promoter -- HIV-1 mRNA expression -- Retroviruses and Env-containing LTR-retroelements depend on specialized mRNA export mechanisms to express their full-length mRNA -- The Rev/CRM1 mRNA export pathway -- HIV-1 regulatory and accessory proteins -- HIV-1 proteins as molecular adaptors -- The importance Of CD4 regulation -- HIV-1 genome.…”
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Molecular pathogenesis and prevention of Staphylococcus aureus infections

Table of Contents: “…Contents: The envelope of gram-positive bacteria -- Anchoring proteins -- Signal peptides of staphylococcal surface proteins -- Protein traffic to the cell wall envelope of S. aureus -- Fate of S. aureus injected into mice bloodstream -- Abscess formation -- What are the protective antigens of staphylococci? …”
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Molecular pathogenesis and prevention of Staphylococcus aureus infections

Table of Contents: “…Contents: The envelope of gram-positive bacteria -- Anchoring proteins -- Signal peptides of staphylococcal surface proteins -- Protein traffic to the cell wall envelope of S. aureus -- Fate of S. aureus injected into mice bloodstream -- Abscess formation -- What are the protective antigens of staphylococci? …”
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HIV peculiarities of its genome /

Table of Contents: “…Contents: Molecular organization of HIV -- HIV-1 mRNAs -- Env and HIV-1 entry -- Tat and Rev are essential RNA binding HIV-1 proteins -- HIV-1 promoter -- HIV-1 mRNA expression -- Retroviruses and Env-containing LTR-retroelements depend on specialized mRNA export mechanisms to express their full-length mRNA -- The Rev/CRM1 mRNA export pathway -- HIV-1 regulatory and accessory proteins -- HIV-1 proteins as molecular adaptors -- The importance Of CD4 regulation -- HIV-1 genome.…”
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HIV peculiarities of its genome /

Table of Contents: “…Contents: Molecular organization of HIV -- HIV-1 mRNAs -- Env and HIV-1 entry -- Tat and Rev are essential RNA binding HIV-1 proteins -- HIV-1 promoter -- HIV-1 mRNA expression -- Retroviruses and Env-containing LTR-retroelements depend on specialized mRNA export mechanisms to express their full-length mRNA -- The Rev/CRM1 mRNA export pathway -- HIV-1 regulatory and accessory proteins -- HIV-1 proteins as molecular adaptors -- The importance Of CD4 regulation -- HIV-1 genome.…”
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The spindle checkpoint

Table of Contents: “…-- Unattached kinetochores -- Lack of tension -- Checkpoint components -- Budding yeast genetic screens -- Microcolony assay -- Localisation of Mad proteins -- Checkpoint proteins are all recruited kinetochores -- Role of kinetochores -- Global signaling -- Identification of Cdc20 as the checkpoint effector -- CdC20-APC -- FRAP -- Mad1/Mad2 complex as a template -- The anaphase promoting complex (APC) -- How is anaphase onset inhibited -- Mad2 and Mad3 bind mitotic APC -- Separase regulation by securin -- Error correction -- Chromosomal passenger proteins -- How to sense a lack of tension? …”
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