Search Results - "proteins"

Molecular structure of amyloid and prion fibrils insights from solid state NMR /

“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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[PIN+] prions beget prions /

Table of Contents: “…Contents: Prions are infectious proteins -- [PIN+] is a prion of Rnq1 - [PIN+] exists as different variants -- Prions can affect the stability of other variants of the same prion, or of heterologous prions.…”
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Propagation and variability of the yeast [PSI+] prion

Table of Contents: “…Contents: Prion -- Yeast prions as non-chromosomal genetic determinants -- Modular structure of the Sup35 protein responsible for the yeast [PSI+] prion -- Role of the Hsp104 chaperone in [PSI+] prion propagation -- Two-level structure of the [PSI+] prion aggregates and methods for studying the size of prion polymers -- Non-prion amyloids in yeast -- Variability of the yeast [PSI+] prion.…”
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Similarities between prion diseases and other neurodegenerative diseases

Table of Contents: “…Contents: Pathology of diseases -- Prion diseases -- The first family with a prion mutation: Creutzfeldt-Jacob disease -- Alzheimer's disease -- 7Mb duplication of locus around APP -- APP probably a locus for "sporadic" Alzheimer's disease -- Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia -- Iowa kindred structure -- alpha-synuclein -- Diseases with only Tau pathology -- The microtubule associated protein tau -- Evolution of human tau haplotypes -- Tagging SNPs selection -- More complex than just H1/H2 -- Association with PSP is driven by H1c allele -- Primary tauopathies -- "Prion-like " behaviour of A-beta -- Does the "spreading" of diseases reflect a less extreme version of infection? …”
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Predicting TSE transmission

Table of Contents: “…Contents: The TSEs continue to pose a problem to animal and human health -- The vCJD epidemic appears to be in decline but new risks of human to human transmission are now apparent -- Chronic wasting disease is a major problem currently in the US although its presence has not yet been detected in Europe -- Predicting and preventing transmission of disease requires an understanding of the routes of transmission within and between animals and the host factors which determine susceptibility -- We have studied natural disease and both in vivo and in vitro model systems to unravel the basic mechanisms of disease -- PrP protein has a central role in the outcome disease and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent -- Precisely how host PrP influences the outcome of disease has not been established -- Both mutations and glycosylation can profoundly influence transmission both within and between species.…”
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The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR

Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
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Transgenic mouse models of prion diseases

Table of Contents: “…Contents: Prions represent a new biological paradigm of protein-mediated information transfer -- Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs) -- Many unresolved issues remain including the exact molecular nature of the prion, the detailed mechanism of prion propagation, and the mechanism by which prion diseases can be both genetic and infectious -- The factors governing the transmission of prions between species remain unclear, in particular the means by which prion strains and PrP primary structure interact to affect inter-species prion transmission -- Dramatic advances in our understanding of prions have occurred because of their transmissibility to experimental animals and the development of transgenic (Tg) mouse models has done much to further our understanding about various aspects of prion biology.…”
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The genetics and biology of the [Het-s] prion of Podospora

Table of Contents: “…Contents: Mammalian prions -- Fungal prions -- Yeast: [URE3], [PSI+] and [PIN+] -- Filamentous fungi: [Het-s] -- Fungal self non-self recognition -- Heterokaryon incompatibility -- Genetics of [Het-s] -- Maternal inheritance -- Meiotic drive -- In vivo and in vitro aggregation of HET-s protein -- Role of the Hsp104 chaperone in [Het-s] system -- Role of the Hsp104 chaperone in [Het-s] prion propagation -- Podospora anserine.…”
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Mechanisms of yeast prion propagation

“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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Prions and amyloids introduction /

“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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Yeast and fungal prions a help or a hindrance? /

“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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Series

Molecular structure of amyloid and prion fibrils insights from solid state NMR /

“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
Get full text
Series

[PIN+] prions beget prions /

Table of Contents: “…Contents: Prions are infectious proteins -- [PIN+] is a prion of Rnq1 - [PIN+] exists as different variants -- Prions can affect the stability of other variants of the same prion, or of heterologous prions.…”
Get full text
Series

Propagation and variability of the yeast [PSI+] prion

Table of Contents: “…Contents: Prion -- Yeast prions as non-chromosomal genetic determinants -- Modular structure of the Sup35 protein responsible for the yeast [PSI+] prion -- Role of the Hsp104 chaperone in [PSI+] prion propagation -- Two-level structure of the [PSI+] prion aggregates and methods for studying the size of prion polymers -- Non-prion amyloids in yeast -- Variability of the yeast [PSI+] prion.…”
Get full text
Series

Similarities between prion diseases and other neurodegenerative diseases

Table of Contents: “…Contents: Pathology of diseases -- Prion diseases -- The first family with a prion mutation: Creutzfeldt-Jacob disease -- Alzheimer's disease -- 7Mb duplication of locus around APP -- APP probably a locus for "sporadic" Alzheimer's disease -- Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia -- Iowa kindred structure -- alpha-synuclein -- Diseases with only Tau pathology -- The microtubule associated protein tau -- Evolution of human tau haplotypes -- Tagging SNPs selection -- More complex than just H1/H2 -- Association with PSP is driven by H1c allele -- Primary tauopathies -- "Prion-like " behaviour of A-beta -- Does the "spreading" of diseases reflect a less extreme version of infection? …”
Get full text
Series

Predicting TSE transmission

Table of Contents: “…Contents: The TSEs continue to pose a problem to animal and human health -- The vCJD epidemic appears to be in decline but new risks of human to human transmission are now apparent -- Chronic wasting disease is a major problem currently in the US although its presence has not yet been detected in Europe -- Predicting and preventing transmission of disease requires an understanding of the routes of transmission within and between animals and the host factors which determine susceptibility -- We have studied natural disease and both in vivo and in vitro model systems to unravel the basic mechanisms of disease -- PrP protein has a central role in the outcome disease and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent -- Precisely how host PrP influences the outcome of disease has not been established -- Both mutations and glycosylation can profoundly influence transmission both within and between species.…”
Get full text
Series

The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR

Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
Get full text
Series

Transgenic mouse models of prion diseases

Table of Contents: “…Contents: Prions represent a new biological paradigm of protein-mediated information transfer -- Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs) -- Many unresolved issues remain including the exact molecular nature of the prion, the detailed mechanism of prion propagation, and the mechanism by which prion diseases can be both genetic and infectious -- The factors governing the transmission of prions between species remain unclear, in particular the means by which prion strains and PrP primary structure interact to affect inter-species prion transmission -- Dramatic advances in our understanding of prions have occurred because of their transmissibility to experimental animals and the development of transgenic (Tg) mouse models has done much to further our understanding about various aspects of prion biology.…”
Get full text
Series

Glutathione /

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VEGF inhibitors for anti-angiogenic therapy

“…Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease.…”
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