Search Results - "proteins"
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Suggested Topics within your search.
- metabolism 473
- Proteins 414
- genetics 327
- physiology 248
- Protein Conformation 186
- Signal Transduction 180
- chemistry 170
- Cellular signal transduction 152
- Protein Folding 142
- Metabolism 123
- Gene Expression Regulation 120
- drug therapy 119
- Molecular Chaperones 117
- immunology 113
- pathology 111
- Protein folding 101
- methods 98
- Neurodegenerative Diseases 97
- Genetic aspects 94
- Neoplasms 93
- Diseases 92
- Mitochondria 90
- Cancer 88
- pharmacology 84
- therapeutic use 83
- therapy 83
- Nervous system 82
- Transcription Factors 79
- Protein Biosynthesis 78
- Receptors 71
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1401
Advances in Microbial Biotechnology : Current Trends and Future Prospects /
Published 2018Table of Contents: “…Maximizing Expression and Yield of Human Recombinant Proteins from Bacterial Cell Factories for Biomedical Applications -- --Manash P. …”
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1402
Polysaccharide based Nano-Biocarrier in Drug Delivery /
Published 2018Table of Contents: “…Chapter 1 Oral Delivery of Proteins and Polypeptides through Polysaccharide Nanocarriers----Hemant Ramchandra Badwaik, Kartik Nakhate, Leena Kumari, --…”
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1403
Mechanism of prion generation in vitro
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1404
The genetics and biology of the [Het-s] prion of Podospora
Published 2008Table of Contents: “…Contents: Mammalian prions -- Fungal prions -- Yeast: [URE3], [PSI+] and [PIN+] -- Filamentous fungi: [Het-s] -- Fungal self non-self recognition -- Heterokaryon incompatibility -- Genetics of [Het-s] -- Maternal inheritance -- Meiotic drive -- In vivo and in vitro aggregation of HET-s protein -- Role of the Hsp104 chaperone in [Het-s] system -- Role of the Hsp104 chaperone in [Het-s] prion propagation -- Podospora anserine.…”
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1405
Mechanisms of yeast prion propagation
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1406
Chaperones and prions
Published 2008Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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1407
Prions and amyloids introduction /
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1408
Yeast and fungal prions a help or a hindrance? /
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1409
Molecular structure of amyloid and prion fibrils insights from solid state NMR /
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1410
[PIN+] prions beget prions /
Published 2008Table of Contents: “…Contents: Prions are infectious proteins -- [PIN+] is a prion of Rnq1 - [PIN+] exists as different variants -- Prions can affect the stability of other variants of the same prion, or of heterologous prions.…”
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1411
Propagation and variability of the yeast [PSI+] prion
Published 2008Table of Contents: “…Contents: Prion -- Yeast prions as non-chromosomal genetic determinants -- Modular structure of the Sup35 protein responsible for the yeast [PSI+] prion -- Role of the Hsp104 chaperone in [PSI+] prion propagation -- Two-level structure of the [PSI+] prion aggregates and methods for studying the size of prion polymers -- Non-prion amyloids in yeast -- Variability of the yeast [PSI+] prion.…”
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1412
The dark side of amyloid Pmel17, a natural amyloid in melanosome biogenesis /
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1413
Similarities between prion diseases and other neurodegenerative diseases
Published 2008Table of Contents: “…Contents: Pathology of diseases -- Prion diseases -- The first family with a prion mutation: Creutzfeldt-Jacob disease -- Alzheimer's disease -- 7Mb duplication of locus around APP -- APP probably a locus for "sporadic" Alzheimer's disease -- Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia -- Iowa kindred structure -- alpha-synuclein -- Diseases with only Tau pathology -- The microtubule associated protein tau -- Evolution of human tau haplotypes -- Tagging SNPs selection -- More complex than just H1/H2 -- Association with PSP is driven by H1c allele -- Primary tauopathies -- "Prion-like " behaviour of A-beta -- Does the "spreading" of diseases reflect a less extreme version of infection? …”
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1414
Predicting TSE transmission
Published 2008Table of Contents: “…Contents: The TSEs continue to pose a problem to animal and human health -- The vCJD epidemic appears to be in decline but new risks of human to human transmission are now apparent -- Chronic wasting disease is a major problem currently in the US although its presence has not yet been detected in Europe -- Predicting and preventing transmission of disease requires an understanding of the routes of transmission within and between animals and the host factors which determine susceptibility -- We have studied natural disease and both in vivo and in vitro model systems to unravel the basic mechanisms of disease -- PrP protein has a central role in the outcome disease and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent -- Precisely how host PrP influences the outcome of disease has not been established -- Both mutations and glycosylation can profoundly influence transmission both within and between species.…”
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1415
The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR
Published 2008Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
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1416
Transgenic mouse models of prion diseases
Published 2008Table of Contents: “…Contents: Prions represent a new biological paradigm of protein-mediated information transfer -- Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs) -- Many unresolved issues remain including the exact molecular nature of the prion, the detailed mechanism of prion propagation, and the mechanism by which prion diseases can be both genetic and infectious -- The factors governing the transmission of prions between species remain unclear, in particular the means by which prion strains and PrP primary structure interact to affect inter-species prion transmission -- Dramatic advances in our understanding of prions have occurred because of their transmissibility to experimental animals and the development of transgenic (Tg) mouse models has done much to further our understanding about various aspects of prion biology.…”
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1417
The genetics and biology of the [Het-s] prion of Podospora
Published 2008Table of Contents: “…Contents: Mammalian prions -- Fungal prions -- Yeast: [URE3], [PSI+] and [PIN+] -- Filamentous fungi: [Het-s] -- Fungal self non-self recognition -- Heterokaryon incompatibility -- Genetics of [Het-s] -- Maternal inheritance -- Meiotic drive -- In vivo and in vitro aggregation of HET-s protein -- Role of the Hsp104 chaperone in [Het-s] system -- Role of the Hsp104 chaperone in [Het-s] prion propagation -- Podospora anserine.…”
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1418
Mechanisms of yeast prion propagation
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1419
Prions and amyloids introduction /
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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1420
Yeast and fungal prions a help or a hindrance? /
Published 2008“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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