Search Results - "proteins"

The transcription factor NF-Kappa B an evolutionarily conserved mediator of immune and inflammatory responses /

Subjects: “…NF-kappa B (DNA-binding protein).…”
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Skin epigenetics how chromatin regulators orchestrate skin functions /

Table of Contents: “…-- Genes encoding keratinocyte-specific proteins -- Molecular signature of epidermal layers -- Levels of epigenetic regulation -- DNA methylation and hydroxymethylation -- DNA methylation influence on the epidermis -- Post-translational histone/covalent modifications -- Histone acetylation/de-acetylation -- Polycomb-repressive complex -- Polycomb and Trithorax play antagonistic roles -- ATP-dependent chromatin remodeling -- Non-coding RNA-dependent mechanisms -- Nucleus: storage, replication of genetic material -- Topological gene interactomes -- Morphogenesis of the epidermis -- Epidermal differentiation complex -- EDC and Lor relocation to nuclear interior -- p63 and Brg1 ablation results in retention of EDC -- Genome organizer AT-rich binding Satb1 protein -- Transcription factor and epigenetic mechanisms -- Future directions of epigenetic research.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Virology and cancer biology part 2, DNA viruses associated with transformation and tumor formation : the discovery of tumor suppressor genes /

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Iron metabolism and innate immunity

Table of Contents: “…Contents: Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts -- Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins -- The cellular component of this response causes a marked decrease in extracellular iron concentration -- Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration -- It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation -- Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias.…”
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Glutathione transferases

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Iron metabolism and innate immunity

Table of Contents: “…Contents: Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts -- Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins -- The cellular component of this response causes a marked decrease in extracellular iron concentration -- Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration -- It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation -- Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias.…”
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Virology and cancer biology part 2, DNA viruses associated with transformation and tumor formation : the discovery of tumor suppressor genes /

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Glutathione transferases

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Antifungal innate immunity in C. elegans

Subjects: “…Caenorhabditis elegans Proteins immunology.…”
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Protective inflammasome activation in AMD

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Mitochondria and calcium signaling in cell life and cell death

Table of Contents: “…Contents: Calcium signalling, ubiquitous and associated with increased energy demand -- Mitochondria machinery to for taking up calcium from the cytosol -- The transfer of calcium from cytosol to mitochondria (stimulation of oxidative phosphorylation & matching energy supply with demand) -- Mutations in proteins that regulate mitochondrial calcium uptake (causation of a neuromuscular disease, possibly by mitochondrial calcium overload) -- Acute severe calcium overload causes cell death during reperfusion of ischaemic tissues -- The permeability transition pore, a potential therapeutic target.…”
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Complement and T cells

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O-GlcNAc, an essential regulator of numerous cellular pathways

Table of Contents: “…Contents: O-GlcNAc -- A Novel Intracellular Glycan -- Biosynthesis of O-GlcNAc -- Mechanisms by which O-GlcNAc regulates proteins -- Cellular pathways and diseases regulated by O-GlcNAc -- Epigenetics and transcription -- Translation -- Cell cycle -- Nutritional sensing -- Neurodegeneration -- Cancer -- The cellular stress response.…”
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O-GlcNAc, an essential regulator of numerous cellular pathways

Table of Contents: “…Contents: O-GlcNAc -- A Novel Intracellular Glycan -- Biosynthesis of O-GlcNAc -- Mechanisms by which O-GlcNAc regulates proteins -- Cellular pathways and diseases regulated by O-GlcNAc -- Epigenetics and transcription -- Translation -- Cell cycle -- Nutritional sensing -- Neurodegeneration -- Cancer -- The cellular stress response.…”
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Mitochondria and calcium signaling in cell life and cell death

Table of Contents: “…Contents: Calcium signalling, ubiquitous and associated with increased energy demand -- Mitochondria machinery to for taking up calcium from the cytosol -- The transfer of calcium from cytosol to mitochondria (stimulation of oxidative phosphorylation & matching energy supply with demand) -- Mutations in proteins that regulate mitochondrial calcium uptake (causation of a neuromuscular disease, possibly by mitochondrial calcium overload) -- Acute severe calcium overload causes cell death during reperfusion of ischaemic tissues -- The permeability transition pore, a potential therapeutic target.…”
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Complement and T cells

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Inborn errors of ketone body metabolism

Table of Contents: “…Contents: Ketone body metabolism -- Diagnostic approach -- Defects in ketogenesis -- Defects in ketone body utilization (succinyl-CoA:3-ketoacid CoA transferase deficiency, mitochondrial acetoacetyl-CoA thiolase deficiency) -- Molecular basis of mitochondrial acetoacetyl-CoA thiolase deficiency (protein and DNA levels).…”
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Inborn errors of ketone body metabolism

Table of Contents: “…Contents: Ketone body metabolism -- Diagnostic approach -- Defects in ketogenesis -- Defects in ketone body utilization (succinyl-CoA:3-ketoacid CoA transferase deficiency, mitochondrial acetoacetyl-CoA thiolase deficiency) -- Molecular basis of mitochondrial acetoacetyl-CoA thiolase deficiency (protein and DNA levels).…”
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Fermentation Microbiology and Biotechnology, Fourth Edition /

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