Search Results - "proteins"

Complement and organ transplantation

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Acid beta-Glucosidase/Glucocerebrosidase (GCase)

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Interactome networks and human disease

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PTEN Hamartoma-Tumour Syndrome a model for the practice of clinical cancer genetics /

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Introduction to epigenetics

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Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Introduction to epigenetics

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Polyadenylation of mRNA precursors mechanism, regulation and connections with other cellular processes /

Table of Contents: “…Contents: Polyadenylation of mRNA precursors -- The polyadenylation machinery -- A surprising complexity in PAP -- Hyperphosphorylation by MPF inhibits PAP activity -- Gld-2 in cytoplasmic polyadenylation in oocytes -- The polyadenylation machinery -- CPSF-73 is the 3' processing endonuclease -- CPSF-73 is absent in cytoplasmic polyadenylation -- CstF protein interactions -- Regulation of gene expression by alternative polyadenylation -- The C-terminal domain of RNAPII -- The CTD can stimulate 3' cleavage in vitro -- CPSF links transcription and 3' end formation -- RNA15 crosslinks to promoters -- Polyadenylation and links to other cellular processes -- CstF-50 -- BRCA1 -- BARD1 -- BRCA associated ring domain protein -- Why does BARD1 inhibit 3' processing? …”
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Calcium and transcription-coupling

Table of Contents: “…Contents: Calcium sources -- Calcium-regulated transcription factors: Calcium/cAMP response element binding protein (CREB), nuclear factor of activated T-cells (NFAT) and serum response factor (SRF) -- Calcium signaling cascades -- Calcium and cell differentiation -- Calcium and disease.…”
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Developing therapeutic monoclonal antibodies (mAbs) and antibody-based products part 2 of 2 /

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Abeta toxicity 1

Table of Contents: “…Contents: The amyloid plaque -- Impact of delaying onset of AD -- The amyloidocentric theory of Alzheimer's disease -- Compelling evidence for the Abeta theory of AD -- Delay onset of AD by 5 years -- The best target for a disease-modifying drug -- APP structure and domains -- Iron-export ferroxidase activity of beta-amyloid precursor protein -- Age at onset correlates with Abeta isoforms -- Activation of PS1 -- Abeta amyloid -- The mechanism of neurodegeneration -- Abeta metal binding modes -- Current working model of Abeta toxicity -- Abeta amyloid protein: current model consistent with EXAFS -- Metal-protein attenuating compound (MPAC) with moderate affinity for metals -- Clioquinol (CQ, PBT1) the prototypic MPAC -- PBT2: SAR based on rational drug design -- CQ (PBT1) vs. …”
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Series (Alzheimer disease)
Series (Drug discovery and development in the neurosciences)

Abeta toxicity 1

Table of Contents: “…Contents: The amyloid plaque -- Impact of delaying onset of AD -- The amyloidocentric theory of Alzheimer's disease -- Compelling evidence for the Abeta theory of AD -- Delay onset of AD by 5 years -- The best target for a disease-modifying drug -- APP structure and domains -- Iron-export ferroxidase activity of beta-amyloid precursor protein -- Age at onset correlates with Abeta isoforms -- Activation of PS1 -- Abeta amyloid -- The mechanism of neurodegeneration -- Abeta metal binding modes -- Current working model of Abeta toxicity -- Abeta amyloid protein: current model consistent with EXAFS -- Metal-protein attenuating compound (MPAC) with moderate affinity for metals -- Clioquinol (CQ, PBT1) the prototypic MPAC -- PBT2: SAR based on rational drug design -- CQ (PBT1) vs. …”
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Series (Alzheimer disease)
Series (Drug discovery and development in the neurosciences)

Developing therapeutic monoclonal antibodies (mAbs) and antibody-based products part 2 of 2 /

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Astrocytes definition, appearance and general physiology. Part 2 /

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Complement deficiencies in humans

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Complement deficiencies in humans

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Astrocytes definition, appearance and general physiology. Part 2 /

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Vitiligo in vivo and in vitro evidence for epidermal ROS/RNS-mediated regulation/dysregulation /

Table of Contents: “…Contents: Role of inherited vs. induced (tanning) skin colour -- Enhanced pigmentation after sun exposure -- Vitiligo and its characteristics (inherited skin colour loss) -- Correct diagnosis of vitiligo via characteristic fluorescence -- Use of Wood's light for differential diagnosis -- Cause and pathogenesis of vitiligo -- Oxidation and nitration of proteins and peptides in vitiligo and their effects -- DNA damage, T-cell response & p53 in vitiligo -- Treating vitiligo: Reducing oxidation and repigmentation.…”
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TNF superfamily cytokines and receptors in the healthy and diseased immune system

Table of Contents: “…Contents: Genomics of the TNF/TNFR superfamily -- TNF/TNFR signaling types -- Various domains of TNFR -- TNF ligands and receptor binding -- Fas and the TNFR family -- Apoptosis through DISC recruitment -- FAS-FADD crystal structure -- Gene expression through TRAF proteins and regulation by dynamic expression of ligands -- Lymph node development -- Innate immunity enhancement -- B & T cells and the TNFR superfamily -- Multiple programmed cell death pathways -- Osteoclast development -- Molecular mechanisms of genetic diseases and defects in the Fas pathway -- Fas intra and extracellular mutations -- Therapeutics and anti-inflammatory uses of TNF superfamily blockade.…”
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