Search Results - "proteins"

Extracellular domain structures from calcium-sensing and GABA(B) receptors

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Structure and activation of endothelin ETB receptor by endothelin

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Roles of AMPK in energy homeostasis and nutrient sensing

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Phospholipase C Gamma

Table of Contents: “…Contents: PLC-gamma in growth factor signaling -- PLC-gamma as an enzyme -- Substrate and products -- PLC family members -- Domains -- Association of PLC-gamma with activated receptor tyrosine kinases and membranes -- Tyrosine phosphorylation sites of PLC-gamma -- PLC-gamma1 verses PLC-gamma2 -- Measurement of protein and enzymatic activation -- Downstream signaling by PLC-gamma in T cells -- PLC-gamma mediation of integrins during adhesion and spreading -- PLC-gamma biologic roles.…”
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Global analysis of gene translation

Table of Contents: “…Contents: Radiation-induced gene expression has long been considered to play a role in determining cellular radioresponse -- Analyses of single genes and whole genomes indicate that radiation-induced changes at the mRNA level do not correlate with changes in corresponding proteins -- Microarray analysis of polysome-bound RNA indicates that radiation modifies the translational activity of mRNA subpopulations, which correlates with protein products -- Gene translation is considerably more susceptible to radiation-induced changes than is the transcriptome -- Defining the genes whose translation is modified by radiation may provide an approach for identifying critical proteins and pathways that serve as determinants of radiosensitivity.…”
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Phospholipase C Gamma

Table of Contents: “…Contents: PLC-gamma in growth factor signaling -- PLC-gamma as an enzyme -- Substrate and products -- PLC family members -- Domains -- Association of PLC-gamma with activated receptor tyrosine kinases and membranes -- Tyrosine phosphorylation sites of PLC-gamma -- PLC-gamma1 verses PLC-gamma2 -- Measurement of protein and enzymatic activation -- Downstream signaling by PLC-gamma in T cells -- PLC-gamma mediation of integrins during adhesion and spreading -- PLC-gamma biologic roles.…”
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Global analysis of gene translation

Table of Contents: “…Contents: Radiation-induced gene expression has long been considered to play a role in determining cellular radioresponse -- Analyses of single genes and whole genomes indicate that radiation-induced changes at the mRNA level do not correlate with changes in corresponding proteins -- Microarray analysis of polysome-bound RNA indicates that radiation modifies the translational activity of mRNA subpopulations, which correlates with protein products -- Gene translation is considerably more susceptible to radiation-induced changes than is the transcriptome -- Defining the genes whose translation is modified by radiation may provide an approach for identifying critical proteins and pathways that serve as determinants of radiosensitivity.…”
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Expression vs. function of ABC transporters at the blood-brain barrier

Table of Contents: “…Contents: Introduction to the ABC superfamily and the blood-brain barrier (BBB) -- ABCB and P-glycoprotein (ABCB1) at the BBB -- ABCG and BCRP (ABCG2) at the BBB -- ABCC and the Multi-Drug Resistance Proteins (MRPs) at the BBB -- ABC in isolated human brain microvessels -- Pre-clinical and clinical impact in central nervous system research and drug development.…”
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Expression vs. function of ABC transporters at the blood-brain barrier

Table of Contents: “…Contents: Introduction to the ABC superfamily and the blood-brain barrier (BBB) -- ABCB and P-glycoprotein (ABCB1) at the BBB -- ABCG and BCRP (ABCG2) at the BBB -- ABCC and the Multi-Drug Resistance Proteins (MRPs) at the BBB -- ABC in isolated human brain microvessels -- Pre-clinical and clinical impact in central nervous system research and drug development.…”
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The neuronal ceroid lipofuscinoses

Table of Contents: “…Contents: Clinical features of the neuronal ceroid lipofuscinoses -- Genetics -- Genotype/phenotype correlations -- Protein epidemiology -- Mechanisms of neurodegeneration -- Treatment approaches.…”
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Surface-mediated targeting of lentiviral vectors

Table of Contents: “…Contents: In vivo and ex vivo gene therapy -- Cell entry modes of retroviral vectors -- Molecular functions of viral envelope proteins -- Introduction to surface targeting -- Targeting subtypes of lymphocytes and hematopoietic stem cells (Ex vivo) -- In vivo targeting (local vs. systemic administration).…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Colorectal cancer and the rare variant hypothesis

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Colorectal cancer and the rare variant hypothesis

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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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The neutral and nearly neutral theories of molecular evolution part 2 of 2 /

Table of Contents: “…Contents: Nearly neutral model -- Distribution of fitness effects of new mutations -- Predictions of Neutral Theory -- Evolutionary implications of nearly neutral evolution -- Protein stability as an example of evolutionary dynamics.…”
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The neutral and nearly neutral theories of molecular evolution part 2 of 2 /

Table of Contents: “…Contents: Nearly neutral model -- Distribution of fitness effects of new mutations -- Predictions of Neutral Theory -- Evolutionary implications of nearly neutral evolution -- Protein stability as an example of evolutionary dynamics.…”
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Visualization of transcription factor interactions in living cells

Table of Contents: “…Contents: Transcription regulatory proteins -- Combinatorial control of gene expression -- Visualization of transcription factor interactions and modifications in living cells -- New methods development -- Bimolecular fluorescence complementation (BiFC) assays -- Ubiquitin mediated fluorescence complementation (UbFC) assays.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Visualization of transcription factor interactions in living cells

Table of Contents: “…Contents: Transcription regulatory proteins -- Combinatorial control of gene expression -- Visualization of transcription factor interactions and modifications in living cells -- New methods development -- Bimolecular fluorescence complementation (BiFC) assays -- Ubiquitin mediated fluorescence complementation (UbFC) assays.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Structure of thrombin, a Janus-headed proteinase

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