Search Results - "proteins"

A primer on familial cancer genetics

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CML genetic paradigm of targeted therapy, part 2 of 2 /

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CML genetic paradigm of targeted therapy, part 2 of 2 /

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A primer on familial cancer genetics

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Expression vs. function of ABC transporters at the blood-brain barrier

Table of Contents: “…Contents: Introduction to the ABC superfamily and the blood-brain barrier (BBB) -- ABCB and P-glycoprotein (ABCB1) at the BBB -- ABCG and BCRP (ABCG2) at the BBB -- ABCC and the Multi-Drug Resistance Proteins (MRPs) at the BBB -- ABC in isolated human brain microvessels -- Pre-clinical and clinical impact in central nervous system research and drug development.…”
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BACE lead target for orchestrated therapy of Alzheimer's disease /

Subjects: An electronic book accessible through the World Wide Web; click to view

Macrophage paired receptor interactions

Table of Contents: “…Contents: Immunoregulation and cell surface receptors -- Paired receptors -- Inhibitory -- Activating -- Myeloid cells -- X-ray crystallography -- Protein structure Ig superfamily domains -- Evolution Pathogen pressure -- Host environment interactions.…”
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Phospholipase C Gamma

Table of Contents: “…Contents: PLC-gamma in growth factor signaling -- PLC-gamma as an enzyme -- Substrate and products -- PLC family members -- Domains -- Association of PLC-gamma with activated receptor tyrosine kinases and membranes -- Tyrosine phosphorylation sites of PLC-gamma -- PLC-gamma1 verses PLC-gamma2 -- Measurement of protein and enzymatic activation -- Downstream signaling by PLC-gamma in T cells -- PLC-gamma mediation of integrins during adhesion and spreading -- PLC-gamma biologic roles.…”
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Global analysis of gene translation

Table of Contents: “…Contents: Radiation-induced gene expression has long been considered to play a role in determining cellular radioresponse -- Analyses of single genes and whole genomes indicate that radiation-induced changes at the mRNA level do not correlate with changes in corresponding proteins -- Microarray analysis of polysome-bound RNA indicates that radiation modifies the translational activity of mRNA subpopulations, which correlates with protein products -- Gene translation is considerably more susceptible to radiation-induced changes than is the transcriptome -- Defining the genes whose translation is modified by radiation may provide an approach for identifying critical proteins and pathways that serve as determinants of radiosensitivity.…”
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Mechanisms of transcription the eukaryotic pre-initiation complex /

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The complement system an introduction for undergraduates /

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The complement system an introduction for undergraduates /

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Structure and function of adhesion GPCRs and their ligands

Table of Contents: “…Contents: The history, biological functions and architecture of adhesion GPCRs -- The conserved GAIN domain -- Working models for adhesion GPCR activation -- The structures of adhesion GPCR extracellular regions and their ligands -- Similarity of adhesion GPCRs to hormone receptors -- Drugs might affect adhesion GPCRs via the extracellular regions or protein-protein interaction sites.…”
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Endoplasmic reticulum stress in neurodegenerative diseases

Table of Contents: “…Contents: Neurodegenerative disease -- Misfolded aggregates deposited in the brain -- Research strategy -- Prion diseases -- Two conformations of the prion protein -- Experimental scrapie model in mice -- Upregulation of ER chaperones -- ER-stress and UPR in human CJD -- PrP interaction with ER chaperones in brain -- PrPSc induction of ER-stress and neuronal death -- Calcineurin properties -- A novel treatment for prion diseases.…”
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PI3K/AKT signaling In cancer

Table of Contents: “…Contents: PI3K/AKT signal transduction pathway -- Tumors with frequent dysregulation of PI3K signalling -- Modalities for inhibiting PI3K-AKT signaling currently in development -- AKT1/2 inhibitor (Merck) -- PI3K/AKT in breast cancer -- AKTi-1/2 inhibits AKT signaling and causes G1 arrest -- The Herceptin-resistant -- Effect of AKT inhibition on glucose levels -- Mutated elements in mitogenic signaling pathways in tumors -- Coexistent K-Ras or B-Raf mutation -- Genes encoding several components of mitogenic signaling pathways are mutationally activated in tumors -- Integrators of multiple signaling pathways (OR-gates) -- The effects of combined inhibition of AKT and MAPK on the phosphorylation of translational regulatory proteins -- Knockdown of 4EBP1 expression -- Feedback inhibition of insulin/IGF-1 signaling -- The concept of feedback -- Clinical effects of Rapamycin-like drugs -- mTORC1 vs. …”
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PI3K/AKT signaling In cancer

Table of Contents: “…Contents: PI3K/AKT signal transduction pathway -- Tumors with frequent dysregulation of PI3K signalling -- Modalities for inhibiting PI3K-AKT signaling currently in development -- AKT1/2 inhibitor (Merck) -- PI3K/AKT in breast cancer -- AKTi-1/2 inhibits AKT signaling and causes G1 arrest -- The Herceptin-resistant -- Effect of AKT inhibition on glucose levels -- Mutated elements in mitogenic signaling pathways in tumors -- Coexistent K-Ras or B-Raf mutation -- Genes encoding several components of mitogenic signaling pathways are mutationally activated in tumors -- Integrators of multiple signaling pathways (OR-gates) -- The effects of combined inhibition of AKT and MAPK on the phosphorylation of translational regulatory proteins -- Knockdown of 4EBP1 expression -- Feedback inhibition of insulin/IGF-1 signaling -- The concept of feedback -- Clinical effects of Rapamycin-like drugs -- mTORC1 vs. …”
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Endoplasmic reticulum stress in neurodegenerative diseases

Table of Contents: “…Contents: Neurodegenerative disease -- Misfolded aggregates deposited in the brain -- Research strategy -- Prion diseases -- Two conformations of the prion protein -- Experimental scrapie model in mice -- Upregulation of ER chaperones -- ER-stress and UPR in human CJD -- PrP interaction with ER chaperones in brain -- PrPSc induction of ER-stress and neuronal death -- Calcineurin properties -- A novel treatment for prion diseases.…”
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Structure and function of adhesion GPCRs and their ligands

Table of Contents: “…Contents: The history, biological functions and architecture of adhesion GPCRs -- The conserved GAIN domain -- Working models for adhesion GPCR activation -- The structures of adhesion GPCR extracellular regions and their ligands -- Similarity of adhesion GPCRs to hormone receptors -- Drugs might affect adhesion GPCRs via the extracellular regions or protein-protein interaction sites.…”
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Complement in PNH and other hemolytic anaemias part 2 of 3 /

Table of Contents: “…Contents: Genetically defective regulation (somatic) -- PNH: complement–mediated hemolysis -- Flow-cytometry analysis of PNH red cells -- Proteins in the lipid bilayer: GPI-anchors -- Mutations in the PIG-A gene -- Proteins deficient on PNH blood cells -- Mechanism of intravascular hemolysis in PNH -- Mechanism of action of CD59.…”
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Humoral innate immunity and the acute phase response 2

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Series (Innate immunity)
Series (Cytokines)