Search Results - "proteins"

Pre-coupling of receptor oligomers and signaling molecules challenging classical pharmacology /

Table of Contents: “…Contents: Pre-coupling of GPCRs with G proteins and adenylyl cyclase -- GPCR homomers and heteromers -- GPCR oligomer-dependent allosteric modulations between orthosteric ligands -- GPCR heteromer-dependent interactions at the adenylyl cyclase level -- The striatal adenosine A2A-dopamine D2 receptor heterotetramer.…”
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Subversion of complement by bacteria

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Integrated view on a eukaryotic osmoregulation system

Table of Contents: “…Contents: Osmoregulation -- Cell compression and macromolecular crowding -- Osmolyte accumulation -- Metabolism and signalling -- Modelling, simulation and prediction -- Multi-level control of osmolyte accumulation -- Mitogen activated protein kinase signalling -- Signalling crosstalk -- Synthetic biology approaches to osmoregulation.…”
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Structure of thrombin, a Janus-headed proteinase

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The recognition of misfolded glycoproteins in the endoplasmic reticulum

Table of Contents: “…Contents: The endoplasmic reticulum -- Protein folding -- Molecular chaperones -- N-glycosylation -- Lectin-type chaperones calnexin and calreticulin -- Link between protein folding and glycosylation -- ER quality control.…”
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The recognition of misfolded glycoproteins in the endoplasmic reticulum

Table of Contents: “…Contents: The endoplasmic reticulum -- Protein folding -- Molecular chaperones -- N-glycosylation -- Lectin-type chaperones calnexin and calreticulin -- Link between protein folding and glycosylation -- ER quality control.…”
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Immunoaffinity chromatography and gentle IAC purification of complexes

Table of Contents: “…Contents: Protein purification -- Immunoaffinity chromatography -- Monoclonal antibodies vs. polyclonal antibodies -- Fusion protein purification methods.…”
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Immunoaffinity chromatography and gentle IAC purification of complexes

Table of Contents: “…Contents: Protein purification -- Immunoaffinity chromatography -- Monoclonal antibodies vs. polyclonal antibodies -- Fusion protein purification methods.…”
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Structural and mechanistic insights into the neurotensin receptor

Table of Contents: “…Contents: G protein-coupled receptors -- Neurotensin receptor -- Peptide agonist neurotensin tools for crystallization of membrane proteins -- Conformational thermostabilization -- Crystal structure of NTSR1-GW5 -- Binding mode of neurotensin -- Crystal structures of NTSR1-ELF & NTSR1-LF-prerequisites for G protein activation -- Crystal structure of NTSR1-EL -- Constitutive activity -- Molecular dynamics simulations.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Structural and mechanistic insights into the neurotensin receptor

Table of Contents: “…Contents: G protein-coupled receptors -- Neurotensin receptor -- Peptide agonist neurotensin tools for crystallization of membrane proteins -- Conformational thermostabilization -- Crystal structure of NTSR1-GW5 -- Binding mode of neurotensin -- Crystal structures of NTSR1-ELF & NTSR1-LF-prerequisites for G protein activation -- Crystal structure of NTSR1-EL -- Constitutive activity -- Molecular dynamics simulations.…”
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AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance by Kim, Sang Geon

Subjects: An electronic book accessible through the World Wide Web; click to view

EGF-TM7 receptors

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Activation of PTK receptors in solid human tumors

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EGFR targeted therapies in lung cancer

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Receptor tyrosine kinases function, families and evolution /

Table of Contents: “…Contents: History of protein phosphorylation -- Protein kinase bioinformatics -- History of tyrosine phosphorylation and functions of tyrosine kinases -- Genomic catalogues of protein kinases (kinomes) -- The human kinome -- The evolution of kinomes -- The human tyrosine kinase subfamily -- Receptor and nonreceptor tyrosine kinases -- Activation of receptor tyrosine kinases by ligand-induced dimerization -- Signal transduction pathways downstream of receptor tyrosine kinases -- Insulin and IOGF-1 receptor signaling via the mTOR pathway -- mTOR-S6 kinase feedback loop leading to downregulation of the IRS1 docking protein and insulin resistance -- History of Eph receptor tyrosine kinases and their ephrin ligands -- Bidirectional signaling via Eph-ephrin interactions on neighboring cells -- Simultaneous signaling by EphAs and ephrin As in motor neurons -- Compartmentalized signaling by receptor tyrosine kinases and their ligands through localization to discrete membrane domains -- Protein kinases and human disease -- Human cancer genes and protein kinases -- Protein kinases and phosphatases and cancer -- The long road to Gleevec.…”
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The growth hormone/insulin-like growth factor-1 axis in health and disease

Table of Contents: “…Contents: Lack of growth hormone leads to short stature and excess leads to gigantism or acromegaly -- IGF-1 is the main mediator of these effects -- Both hormones have similar but different effects on protein, lipid and carbohydrate metabolism as well as bone development and growth -- The IGF system plays a role in cancer progression.…”
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Receptor tyrosine kinases function, families and evolution /

Table of Contents: “…Contents: History of protein phosphorylation -- Protein kinase bioinformatics -- History of tyrosine phosphorylation and functions of tyrosine kinases -- Genomic catalogues of protein kinases (kinomes) -- The human kinome -- The evolution of kinomes -- The human tyrosine kinase subfamily -- Receptor and nonreceptor tyrosine kinases -- Activation of receptor tyrosine kinases by ligand-induced dimerization -- Signal transduction pathways downstream of receptor tyrosine kinases -- Insulin and IOGF-1 receptor signaling via the mTOR pathway -- mTOR-S6 kinase feedback loop leading to downregulation of the IRS1 docking protein and insulin resistance -- History of Eph receptor tyrosine kinases and their ephrin ligands -- Bidirectional signaling via Eph-ephrin interactions on neighboring cells -- Simultaneous signaling by EphAs and ephrin As in motor neurons -- Compartmentalized signaling by receptor tyrosine kinases and their ligands through localization to discrete membrane domains -- Protein kinases and human disease -- Human cancer genes and protein kinases -- Protein kinases and phosphatases and cancer -- The long road to Gleevec.…”
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Series (Signal transduction)
Series (World of hormones)

The growth hormone/insulin-like growth factor-1 axis in health and disease

Table of Contents: “…Contents: Lack of growth hormone leads to short stature and excess leads to gigantism or acromegaly -- IGF-1 is the main mediator of these effects -- Both hormones have similar but different effects on protein, lipid and carbohydrate metabolism as well as bone development and growth -- The IGF system plays a role in cancer progression.…”
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