Search Results - "proteins"

Chromatin and transcription

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The hyperphosphorylation of Tau and Alzheimer's disease by Goedert, Michel.spk

Table of Contents: “…Contents: Alzheimer's disease -- Extracellular plaques -- Intracellular tangles -- Tau filaments -- Tau hyperphosphorylation -- Other tauopathies -- Mouse models of tauopathy -- Protein kinase inhibitors -- Protein phosphatase activators.…”
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Structural and mechanistic insights into the neurotensin receptor

Table of Contents: “…Contents: G protein-coupled receptors -- Neurotensin receptor -- Peptide agonist neurotensin tools for crystallization of membrane proteins -- Conformational thermostabilization -- Crystal structure of NTSR1-GW5 -- Binding mode of neurotensin -- Crystal structures of NTSR1-ELF & NTSR1-LF-prerequisites for G protein activation -- Crystal structure of NTSR1-EL -- Constitutive activity -- Molecular dynamics simulations.…”
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Pre-coupling of receptor oligomers and signaling molecules challenging classical pharmacology /

Table of Contents: “…Contents: Pre-coupling of GPCRs with G proteins and adenylyl cyclase -- GPCR homomers and heteromers -- GPCR oligomer-dependent allosteric modulations between orthosteric ligands -- GPCR heteromer-dependent interactions at the adenylyl cyclase level -- The striatal adenosine A2A-dopamine D2 receptor heterotetramer.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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The ERK1/2 MAPK cascade

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The ERK1/2 MAPK cascade

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Hormone mechanisms

Table of Contents: “…Contents: Hormone action via G-protein -- Steroid hormone action in nucleus -- Insulin action in cytosol and nucleus -- Course summary.…”
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Hormone mechanisms

Table of Contents: “…Contents: Hormone action via G-protein -- Steroid hormone action in nucleus -- Insulin action in cytosol and nucleus -- Course summary.…”
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Dicer and R2D2

Table of Contents: “…Contents: Double-stranded RNA (dsRNA) processing by Dicer -- dsRNA-binding domain (dsRBD) protein partners (e.g. R2D2) of Dicer -- Dicer-mediated RISC assembly -- Sensing of thermodynamic asymmetry of small RNA duplexes by the Dicer/dsRBD partner complex.…”
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Dicer and R2D2

Table of Contents: “…Contents: Double-stranded RNA (dsRNA) processing by Dicer -- dsRNA-binding domain (dsRBD) protein partners (e.g. R2D2) of Dicer -- Dicer-mediated RISC assembly -- Sensing of thermodynamic asymmetry of small RNA duplexes by the Dicer/dsRBD partner complex.…”
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Activation of gene expression by double-stranded RNAs

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Translation initiation

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Idiopathic thrombocytopenic purpura

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Idiopathic thrombocytopenic purpura

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PSD-95 dynamic localization of PSD-95 and glutamate receptors at postsynaptic sites /

Table of Contents: “…Contents: PSD-95 -- Structural proteins -- PSD-95 identification and structure -- Glutamatergic synapse -- PSD-95 anchors glutamate receptors -- Alpha-actinin anchors PSD-95 -- AMPAR and NMDAR -- Alpha-actinin function and binding -- Ca2+/CaM binding to PSD-95 -- Effect of Ca2+/CaM on PSD-95 -- Palmitoylation/depalmitoylation cycle of PSD-95 -- Long term depression (LTD) -- Homeostatic downscaling.…”
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Computational modelling of GPCR signalling dynamics

Table of Contents: “…Contents: GPCRs signalling kinetics can be modelled using simple equations -- Link between computational modelling and pharmacology -- Yeast are excellent system for computational models -- RGS proteins show non-intuitive activity -- Kinetic models of GPCRs can model agonist bias.…”
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Computational modelling of GPCR signalling dynamics

Table of Contents: “…Contents: GPCRs signalling kinetics can be modelled using simple equations -- Link between computational modelling and pharmacology -- Yeast are excellent system for computational models -- RGS proteins show non-intuitive activity -- Kinetic models of GPCRs can model agonist bias.…”
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PSD-95 dynamic localization of PSD-95 and glutamate receptors at postsynaptic sites /

Table of Contents: “…Contents: PSD-95 -- Structural proteins -- PSD-95 identification and structure -- Glutamatergic synapse -- PSD-95 anchors glutamate receptors -- Alpha-actinin anchors PSD-95 -- AMPAR and NMDAR -- Alpha-actinin function and binding -- Ca2+/CaM binding to PSD-95 -- Effect of Ca2+/CaM on PSD-95 -- Palmitoylation/depalmitoylation cycle of PSD-95 -- Long term depression (LTD) -- Homeostatic downscaling.…”
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Polycomb epigenetic mechanisms part 1 of 2, role of PcG complexes /

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