Search Results - "proteins"

Cargo receptors for selective autophagy

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Pathogenic mechanisms in prion disease

Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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Pathogenic mechanisms in prion disease

Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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Cargo receptors for selective autophagy

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The interaction network of the GroEL chaperonin

Table of Contents: “…Contents: De novo protein folding and proteome maintenance critically depend on molecular chaperones -- Transitions during protein folding -- Chaperone assisted protein folding -- Productive protein folding is often competed by aggregation -- Reconstitution of GroEL-assisted folding -- GroEL and GroES function as a folding cage for proteins up to 60 kDa -- GroEL structure -- Which proteins need GroEL/GroES for folding? …”
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The recognition of misfolded glycoproteins in the endoplasmic reticulum

Table of Contents: “…Contents: The endoplasmic reticulum -- Protein folding -- Molecular chaperones -- N-glycosylation -- Lectin-type chaperones calnexin and calreticulin -- Link between protein folding and glycosylation -- ER quality control.…”
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The physiology and pathology of coagulation factor XI

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The physiology and pathology of coagulation factor XI

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Mitochondrial transporters and disease part 2 of 2, structure and regulation /

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Mitochondrial transporters and disease part 2 of 2, structure and regulation /

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From CagA to CagA the metamorphoses of the Helicobacter pylori's cytotoxin-associated gene A into the cancer-associated gene A /

Subjects: “…cagA protein, Helicobacter pylori.…”
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Negative regulation of RTKs receptor ubiquitylation, endocytosis and feedback loops /

Table of Contents: “…Contents: Signal transduction by growth factor-activated protein tyrosine kinase receptors -- Receptor endocytosis -- The three vesicular sorting steps occurring at the plasma membrane, in endosomes and in a pre-lysosomal compartment -- The emerging role of mono-ubiquitin and ubiquitin-binding proteins in sorting of active receptors to degradation.…”
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The molecular basis of insulin action

Table of Contents: “…Contents: Mechanisms to diabetes -- The insulin response -- Growth factor receptor tyrosine kinases -- The insulin receptor -- The substrate hypothesis of insulin action -- The family of Irs-proteins -- The insulin signaling cascade -- Role of the Irs2 signaling system.…”
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PI 3-Kinase signalling enzymes & lipid messengers

Subjects: “…Receptor Protein-Tyrosine Kinases.…”
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RTKs activate the ERK 1/2 MAPK cascade

Subjects: “…Receptor Protein-Tyrosine Kinases.…”
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SH2-containing PTPs (Shps) in RTK signaling and disease

Subjects: “…Receptor Protein-Tyrosine Kinases.…”
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Structural basis for Fibroblast Growth Factor (FGF) receptor activation implications in development and disease /

Subjects: “…Receptor Protein-Tyrosine Kinases.…”
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Bioinspired and biomimetic systems for drug, protein and gene delivery / by Gu, Zhongwei

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Protein networks of voltage-gated Ca2+ channels proteomic & functional analysis of local Ca2+ signalling /

“…Protein networks of voltage-gated calcium channels…”
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Endoplasmic reticulum protein folding and control of calcium homeostasis

Table of Contents: “…Contents: Quality control -- Chaperone and folding enzyme system in the endoplasmic reticulum involved in prevention of deployment of misfolded proteins -- Impaired protein folding is responsible for many pathologies in humans including Alzheimer's, CMT and cystic fibrosis -- Deficiency in endoplasmic reticulum calcium binding chaperons impacts on embryonic development due to defect in calcium homeostasis and protein folding.…”
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