Search Results - "proteins"

WNK1 pathway and its role in regulating hypertension

Table of Contents: “…Contents: Mutations in WNK kinases cause familial hypertension -- WNK1 interacts with and activates SPAK and OSR1 -- Physiological functions of SPAK and OSR1 -- Hyperosmotic conditions affect NKCC1 via WNK1 and SPAK/OSR1 -- A suggested mechanism of action for Thiazide diuretics in Gordon's syndrome patients -- How the WNK pathway regulates blood pressure-a current model -- Defining physiological roles of SPAK in knock-in mice -- MO25 also regulates the activity of SPAK/OSR1 -- Functions and schematic representation of LKB1 and SPAK/OSR1 protein complexes.…”
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Synthetic peptides a user's guide /

Subjects: An electronic book accessible through the World Wide Web; click to view

Chromatin architecture and alterations in the control of gene regulation

Table of Contents: “…Contents: The chromatin environment -- Hierarchical organization of chromatin fibers within interphase chromosomes -- Milestone experiments that linked chromatin architecture and gene expression -- Proteins and processes that influence both chromatin fiber architecture and gene expression -- Core histone N-terminal tail domains -- Core histone sequence variants -- Linker histones -- Heterochromatin proteins -- Histone post-translational modifications -- The structurally dynamic nature of the genome in vivo and its relation to gene expression.…”
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Mapping the molecular chaperone interaction network in yeast

Table of Contents: “…Contents: Large scale proteomic screening in yeast -- The TAP-tag pulldown approach -- Understanding the principles governing protein homeostasis -- Mapping the network of the Hsp90 chaperone using physical and genetic interaction screens -- Unraveling the role of Hsp90 in pre-rRNA processing.…”
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Mapping the molecular chaperone interaction network in yeast

Table of Contents: “…Contents: Large scale proteomic screening in yeast -- The TAP-tag pulldown approach -- Understanding the principles governing protein homeostasis -- Mapping the network of the Hsp90 chaperone using physical and genetic interaction screens -- Unraveling the role of Hsp90 in pre-rRNA processing.…”
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Nucleotide dependent functioning of bacterial enhancer binding proteins, activators of sigma54 RNA polymerase

Table of Contents: “…Contents: Understanding the origins of nucleotide driven conformational change -- Molecular motors powered by ATP -- ATPases belonging to the AAA protein family -- PspF from E.coli -- Phage shock genes -- ATP transition state analogue ADPAlF -- X-ray crystallographic structural analysis -- Initiation of conformational changes -- Role of structural changes in sigma54 subunit -- Formation of open promoter complexes -- Changes in DNA binding properties of sigma54 -- Structural organisation of the RNAP holoenzyme.…”
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Nucleotide dependent functioning of bacterial enhancer binding proteins, activators of sigma54 RNA polymerase

Table of Contents: “…Contents: Understanding the origins of nucleotide driven conformational change -- Molecular motors powered by ATP -- ATPases belonging to the AAA protein family -- PspF from E.coli -- Phage shock genes -- ATP transition state analogue ADPAlF -- X-ray crystallographic structural analysis -- Initiation of conformational changes -- Role of structural changes in sigma54 subunit -- Formation of open promoter complexes -- Changes in DNA binding properties of sigma54 -- Structural organisation of the RNAP holoenzyme.…”
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Nucleotide dependent functioning of bacterial enhancer binding proteins, activators of sigma54 RNA polymerase

Table of Contents: “…Contents: Understanding the origins of nucleotide driven conformational change -- Molecular motors powered by ATP -- ATPases belonging to the AAA protein family -- PspF from E.coli -- Phage shock genes -- ATP transition state analogue ADPAlF -- X-ray crystallographic structural analysis -- Initiation of conformational changes -- Role of structural changes in sigma54 subunit -- Formation of open promoter complexes -- Changes in DNA binding properties of sigma54 -- Structural organisation of the RNAP holoenzyme.…”
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Rab GTPases and membrane trafficking

Subjects: An electronic book accessible through the World Wide Web; click to view

Idiopathic thrombocytopenic purpura

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Serpins and the serpinopathies

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The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui

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Serpins and the serpinopathies

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The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui

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Computational methods in analysis of gene regulation and protein interactions

Table of Contents: “…Contents: Finding regulatory motifs -- Finding motifs using target sets of promoters -- Problem definition -- The Amadeus motif finding algorithm -- Architecture, benchmark results and global analysis -- Finding transcriptional programs and their regulatory motifs -- Problem definition -- The Allegro software for recovering transcriptional program -- Results on yeast osmotic shock expression profiles -- Recovering microRNA binding motifs from 3' UTRs using stem cell expression profiles -- Discovering a novel motif pair in C. elegans -- Utilizing network information -- Using expression and protein interaction data -- Problem definition and the Matisse algorithm -- Demonstration of Matisse on yeast osmotic shock data -- Comparison of Matisse to other algorithms -- Demonstration of Matisse on human stem cell data -- The pluripotency network -- Using expression and protein interaction data with interaction confidence -- The Cezanne algorithm -- DNA damage response in yeast.…”
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Dicer and R2D2

Table of Contents: “…Contents: Double-stranded RNA (dsRNA) processing by Dicer -- dsRNA-binding domain (dsRBD) protein partners (e.g. R2D2) of Dicer -- Dicer-mediated RISC assembly -- Sensing of thermodynamic asymmetry of small RNA duplexes by the Dicer/dsRBD partner complex.…”
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Gene sharing and evolution the diversity of protein functions / by Piatigorsky, Joram

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The silent revolution an introduction to gene regulation by microRNAs /

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Role and regulation of Cdk inhibitors in development and cancer

Table of Contents: “…Contents: Somatic cell cycle -- Rb pathway -- Positive regulation of G1 phase by phosphorylation of the retinoblastoma protein (Rb) by cyclin-dependent kinases (Cdks) -- Negative regulation of G1 by Cdk-inhibitory proteins (CKIs) -- Rb pathway is often disrupted in cancers -- Two families of CKIs, differential expression in embryogenesis and adult mouse tissues -- Loss of p18Ink4c and p19ink4d induces male sterility -- Loss of p19Ink4d induces progressive deafness after birth -- Loss of p19Ink4d and p27Kip1 induces re-entry of differentiated postmitotic neurons in cycle after birth -- Loss of Ink4c and Patched or p53 induces medulloblastoma, a pediatric tumor of the cerebellum -- CKIs are required for exit from and maintenance of cell cycle exit, or quiescence, a reversible state -- Loss of CKIs leads to sterility, deafness and cancers.…”
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Role and regulation of Cdk inhibitors in development and cancer

Table of Contents: “…Contents: Somatic cell cycle -- Rb pathway -- Positive regulation of G1 phase by phosphorylation of the retinoblastoma protein (Rb) by cyclin-dependent kinases (Cdks) -- Negative regulation of G1 by Cdk-inhibitory proteins (CKIs) -- Rb pathway is often disrupted in cancers -- Two families of CKIs, differential expression in embryogenesis and adult mouse tissues -- Loss of p18Ink4c and p19ink4d induces male sterility -- Loss of p19Ink4d induces progressive deafness after birth -- Loss of p19Ink4d and p27Kip1 induces re-entry of differentiated postmitotic neurons in cycle after birth -- Loss of Ink4c and Patched or p53 induces medulloblastoma, a pediatric tumor of the cerebellum -- CKIs are required for exit from and maintenance of cell cycle exit, or quiescence, a reversible state -- Loss of CKIs leads to sterility, deafness and cancers.…”
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