Search Results - "proteins"

G-Protein coupled receptors in drug discovery

Table of Contents: “…Contents: The G-protein coupled receptor superfamily -- GPCRs as drug targets -- Approved GPCR drugs -- Why the reduction in GPCR drugs -- New screening technologies and new drug targets.…”
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Genome-wide analyses of protein-DNA interactions

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Endoplasmic reticulum, protein synthesis and translocation machinery

Table of Contents: “…Contents: Protein sorting in the eukaryotic cell -- The discovery of the secretory pathway -- Overview discussion of the structure/function of the endoplasmic reticulum -- Experimental protocols and landmark experiments leading to the discovery of protein translocation -- The signal hypothesis -- Signal sequence structure -- Signal sequence recognition -- SRP receptor and targeting to the ER -- Mechanism of protein translocation and the protein translocation channel -- Translational regulation on the ER -- The unfolded protein response -- mRNA partitioning in the cell -- Are there alternative pathways for compartmentalizing protein synthesis?…”
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The role of chaperones and Sec machinery in protein secretion

Table of Contents: “…Contents: Importance of protein translocation -- Identification of Sec factors -- Structure and function of translocon, an evolutionarily conserved membrane protein complex that serves as a polypeptide-conducting channel -- Structure and function of SecA, a translocation-driving ATPase -- Unique regulation of SecA by SecM, a protein that interacts with the ribosomal exit tunnel.…”
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Parathyroid hormone and parathyroid hormone-related protein

Subjects: “…Parathyroid Hormone-Related Protein. 112482…”
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Sustainable Protein Production and Consumption: Pigs or Peas? by Aiking, Harry

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Genome-wide analyses of protein-DNA interactions

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Protein networks and analysis of global gene expression

Table of Contents: “…Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.…”
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Endoplasmic reticulum, protein synthesis and translocation machinery

Table of Contents: “…Contents: Protein sorting in the eukaryotic cell -- The discovery of the secretory pathway -- Overview discussion of the structure/function of the endoplasmic reticulum -- Experimental protocols and landmark experiments leading to the discovery of protein translocation -- The signal hypothesis -- Signal sequence structure -- Signal sequence recognition -- SRP receptor and targeting to the ER -- Mechanism of protein translocation and the protein translocation channel -- Translational regulation on the ER -- The unfolded protein response -- mRNA partitioning in the cell -- Are there alternative pathways for compartmentalizing protein synthesis?…”
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The role of chaperones and Sec machinery in protein secretion

Table of Contents: “…Contents: Importance of protein translocation -- Identification of Sec factors -- Structure and function of translocon, an evolutionarily conserved membrane protein complex that serves as a polypeptide-conducting channel -- Structure and function of SecA, a translocation-driving ATPase -- Unique regulation of SecA by SecM, a protein that interacts with the ribosomal exit tunnel.…”
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Parathyroid hormone and parathyroid hormone-related protein

Subjects: “…Parathyroid Hormone-Related Protein. 112482…”
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G-Protein coupled receptors in drug discovery

Table of Contents: “…Contents: The G-protein coupled receptor superfamily -- GPCRs as drug targets -- Approved GPCR drugs -- Why the reduction in GPCR drugs -- New screening technologies and new drug targets.…”
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Protein degradation and defense against neurodegenerative disease part 1 of 2 /

Table of Contents: “…Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies.…”
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Protein degradation and defense against neurodegenerative disease part 2 of 2 /

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Initiation and elongation of mammalian mitochondrial protein synthesis

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Calcium regulation of transcription in plants

Subjects: “…Calcium-binding proteins.…”
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DNA replication

Table of Contents: “…-- Fidelity: exonuclease activity -- Fidelity of DNA synthesis -- Processivity of the DNA polymerase -- Processivity factors -- DNA unwinding: helicase protein -- Mechanism of double helical DNA strand separation -- Mechanism of ATPase and DNA translocation -- Helicase functions in conjunction with the DNA polymerase -- Synergy between the replication proteins in catalyzing DNA replication -- Primers for DNA replication -- Properties of the DNA primase.…”
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Handbook of biologically active peptides

Subjects: “…Protein engineering.…”
An electronic book accessible through the World Wide Web; click to view

Exploration and analysis of DNA microarray and other high dimensional data / by Amaratunga, Dhammika, 1956-

Subjects: “…Protein microarrays Statistical methods.…”
An electronic book accessible through the World Wide Web; click to view

LKB1 pathway and its role in cancer

Table of Contents: “…Contents: Mutations in LKB1 kinase cause Peutz Jeghers cancer syndrome -- LKB1-activation and effects -- LKB1/AMPK signaling pathway inhibits mTOR -- Evaluating the role of LKB1 in regulating PTEN-induced tumourigenesis -- AMPK-activators-mechanisms of action -- AMPK-activators delay tumor onset in mice -- Metformin as a useful drug in cancer prevention -- The LKB1:STRAD:MO25 complex -- Potential evolution of a pseudokinase -- LKB activation by STRAD and MO25 -- Location of LKB1 cancer mutations -- Activating protein kinases as a key challenge -- Analysis of the NUAK protein kinase -- Studying the role LKB1/NUAK1 signaling pathway in regulating cell adhesiveness and migration -- Modeling the novel LKB1.…”
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