Search Results - "proteins"

Protein turnover by Waterlow, J. C. (John Conrad)

Subjects: “…Proteins Metabolism.…”
An electronic book accessible through the World Wide Web; click to view

Protein physics a course of lectures / by Finkelstein, Alexei V.

Subjects: An electronic book accessible through the World Wide Web; click to view

Protein condensation kinetic pathways to crystallization and disease / by Gunton, J. D. (James D.), 1937-

Subjects: “…Proteins.…”
An electronic book accessible through the World Wide Web; click to view

Protein evolution by Patthy, László

Table of Contents: “…Protein-coding genes -- Protein structure -- Mutations -- Evolution of protein-coding genes -- Evolution of orthologous proteins -- Formation of novel protein-coding genes -- Evolution of paralogous proteins -- Protein evolution by assembly from modules -- Genome evolution and protein evolution.…”
An electronic book accessible through the World Wide Web; click to view

Protein degradation

Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Protein crystallography

Table of Contents: “…Contents: Protein crystallography -- Protein crystallization methods -- Crystal symmetry -- X-ray intensity data collection -- Electron density equation -- The Patterson function -- Multiple isomorphous replacement phasing -- Fitting the electron density with a model -- Refinement of the model -- Estimating quality of the model.…”
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Protein folding

Table of Contents: “…Contents: Introduction to principles of protein structure -- The basic facts about protein folding -- Cooperativity of protein structure formation -- Necessary and sufficient conditions for protein sequences to fold -- Concept of energy gap -- Protein folding kinetics -- Intermediates and transition state ensembles -- Allatom folding simulations -- Understanding protein folding pathways at atomic detail.…”
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Molecular interactions and activity in proteins

Subjects: “…Proteins Congresses.…”
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Protein oxidation and removal of oxidized proteins by proteolysis

Table of Contents: “…Contents: Oxidized proteins -- Intracellular proteases -- The 20S core proteasome -- Proteasomal particles -- The proteasome-ubiquitin system -- Protein oxidation and proteasome -- Degradation of oxidized proteins and protein function -- Protein surface hydrophobicity -- Unfolding of oxidized proteins -- Stability of the 20S proteasome towards oxidation -- Oxidative stress and protein turnover -- Oxidation-induced proteolysis -- Degradation of oxidized proteins in cells -- What happens if degradation fails? …”
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Protein oxidation and removal of oxidized proteins by proteolysis

Table of Contents: “…Contents: Oxidized proteins -- Intracellular proteases -- The 20S core proteasome -- Proteasomal particles -- The proteasome-ubiquitin system -- Protein oxidation and proteasome -- Degradation of oxidized proteins and protein function -- Protein surface hydrophobicity -- Unfolding of oxidized proteins -- Stability of the 20S proteasome towards oxidation -- Oxidative stress and protein turnover -- Oxidation-induced proteolysis -- Degradation of oxidized proteins in cells -- What happens if degradation fails? …”
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Protein oxidation and removal of oxidized proteins by proteolysis

Table of Contents: “…Contents: Oxidized proteins -- Intracellular proteases -- The 20S core proteasome -- Proteasomal particles -- The proteasome-ubiquitin system -- Protein oxidation and proteasome -- Degradation of oxidized proteins and protein function -- Protein surface hydrophobicity -- Unfolding of oxidized proteins -- Stability of the 20S proteasome towards oxidation -- Oxidative stress and protein turnover -- Oxidation-induced proteolysis -- Degradation of oxidized proteins in cells -- What happens if degradation fails? …”
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Mobility and function in proteins and nucleic acids

Subjects: An electronic book accessible through the World Wide Web; click to view

The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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Apoprotein research

Subjects: An electronic book accessible through the World Wide Web; click to view

The roles of intrinsic disorder in protein interaction networks

Table of Contents: “…Contents: Introducing the protein intrinsic disorder concept and intrinsically disordered proteins (IDPs) -- Structural peculiarities of IDPs -- Sequence peculiarities of IDPs -- Abundance of IDPs and their functions -- Intrinsic disorder in protein interaction networks -- Peculiarities of disorder-based binding and regulation -- Why are IDPs commonly involved in protein interactions?.…”
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Manufacturing of pharmaceutical proteins : from technology to economy / by Behme, Stefan

Subjects: An electronic book accessible through the World Wide Web; click to view

The structural basis for the modulation of protein function by protein phosphorylation

Table of Contents: “…Contents: Physical-chemical basis for phosphorylation -- Discovery -- Glycogen phosphorylase -- Signaling from adrenaline to phosphorylase -- Phosphorylase kinase still a challenge -- Regulation of the cell cycle by phosphorylation -- Cyclin dependent protein kinase 2 activation and inhibition -- Rb the guardian of the genome -- Control by p27 and cyclin E -- Summary of the structural consequences of phosphorylation.…”
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Probing protein-protein interactions with peptide libraries and arrays

Table of Contents: “…Contents: Protein-protein interactions as key to understanding signaling pathways -- Signaling through tyrosine phosphorylation -- Using peptide libraries to study specificities of protein modules -- Peptide library arrays (OPAL) -- OPAL strategies, examples and advantages.…”
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