Search Results - "proteins"

Genetic disorders of carbonic anhydrases II and IV

Table of Contents: “…Contents: Carbonic anhydrase deficiencies -- History of the disease -- Roles of CA II and IV in disease -- Sulfonamide inhibitors for treatment of some disorders -- Characterization of CA isozymes -- CA IV discovery and function -- Mouse knockout models of CA deficiencies -- CA IV, unfolded protein response and retinitis pigmentosa -- ER stress and apoptosis in the choriocapillaris -- Chemical chaperones and treatment of retinitis pigmentosa -- Future studies.…”
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Structure-based drug design targeting infectious disease

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Global strategies for disease detection and treatment proteomics /

Subjects: An electronic book accessible through the World Wide Web; click to view

Genetic disorders of carbonic anhydrases II and IV

Table of Contents: “…Contents: Carbonic anhydrase deficiencies -- History of the disease -- Roles of CA II and IV in disease -- Sulfonamide inhibitors for treatment of some disorders -- Characterization of CA isozymes -- CA IV discovery and function -- Mouse knockout models of CA deficiencies -- CA IV, unfolded protein response and retinitis pigmentosa -- ER stress and apoptosis in the choriocapillaris -- Chemical chaperones and treatment of retinitis pigmentosa -- Future studies.…”
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Structure-based drug design targeting infectious disease

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PSD-95 structural aspects of PDZ domain binding /

Subjects: “…Nerve tissue proteins. 82730…”
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PSD-95 structural aspects of PDZ domain binding /

Subjects: “…Nerve tissue proteins. 82730…”
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Protein chaperones and protection from neurodegenerative diseases

“…Wiley series in protein and peptide science.…”
An electronic book accessible through the World Wide Web; click to view

Machine learning for protein subcellular localization prediction / by Wan, Shibiao, Mak, M. W.

Subjects: “…Proteins Physiological transport Data processing.…”
An electronic book accessible through the World Wide Web; click to view

Initiation and elongation of mammalian mitochondrial protein synthesis

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Protein networks and analysis of global gene expression

Table of Contents: “…Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.…”
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G-Protein coupled receptors in drug discovery

Table of Contents: “…Contents: The G-protein coupled receptor superfamily -- GPCRs as drug targets -- Approved GPCR drugs -- Why the reduction in GPCR drugs -- New screening technologies and new drug targets.…”
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Genome-wide analyses of protein-DNA interactions

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Endoplasmic reticulum, protein synthesis and translocation machinery

Table of Contents: “…Contents: Protein sorting in the eukaryotic cell -- The discovery of the secretory pathway -- Overview discussion of the structure/function of the endoplasmic reticulum -- Experimental protocols and landmark experiments leading to the discovery of protein translocation -- The signal hypothesis -- Signal sequence structure -- Signal sequence recognition -- SRP receptor and targeting to the ER -- Mechanism of protein translocation and the protein translocation channel -- Translational regulation on the ER -- The unfolded protein response -- mRNA partitioning in the cell -- Are there alternative pathways for compartmentalizing protein synthesis?…”
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The role of chaperones and Sec machinery in protein secretion

Table of Contents: “…Contents: Importance of protein translocation -- Identification of Sec factors -- Structure and function of translocon, an evolutionarily conserved membrane protein complex that serves as a polypeptide-conducting channel -- Structure and function of SecA, a translocation-driving ATPase -- Unique regulation of SecA by SecM, a protein that interacts with the ribosomal exit tunnel.…”
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Parathyroid hormone and parathyroid hormone-related protein

Subjects: “…Parathyroid Hormone-Related Protein.…”
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Initiation and elongation of mammalian mitochondrial protein synthesis

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Protein networks and analysis of global gene expression

Table of Contents: “…Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.…”
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Protein degradation and defense against neurodegenerative disease part 1 of 2 /

Table of Contents: “…Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies.…”
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Protein degradation and defense against neurodegenerative disease part 2 of 2 /

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