Search Results - "proteins"

Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G

Subjects: “…Protein Biosynthesis. 112510…”
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Modifications of pyruvate handling in health and disease

Subjects: “…Protein Conformation. 111017…”
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Introduction to the ribosome overview of protein synthesis on the ribosome /

Table of Contents: “…Contents: The understanding of heredity and translation of proteins based on the genetic information -- Intensive structural studies of ribosomes, tRNAs and translation factors -- A historical overview -- Main components of translation.…”
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Antibiotic inhibition of ribosome function

Subjects: “…Protein Biosynthesis. 111861…”
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The structural basis for how the large ribosomal subunit catalyses peptide bond formation

Table of Contents: “…Contents: Overview of protein synthesis by the ribosome -- Nature of the polypeptide exit tunnel in the large subunit -- The ribosome is a ribozyme -- Substrate induced fit at the peptidyl transferase center -- Proton shuttle mechanism and transition state stabilization -- Substrate interactions at the large subunit E-site -- Movie of the peptidyl transferase reaction.…”
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Antibiotics that target the 50S ribosomal subunit resistance and other considerations /

Table of Contents: “…-- Analysis of antibacterial market -- Mechanisms of drug resistance -- Sequestration -- How do antibiotics gain entry into cells -- Porins -- Lack of uptake -- Self-promoted uptake drug modification -- Target modifications -- Drug efflux -- Major superfamilies of transport proteins.…”
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High resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions /

Table of Contents: “…Contents: X-ray crystallography -- Protein synthesis -- High resolution structure of ribosomal subunits -- RNA motifs and interactions -- RNA protein interactions -- Metal ions stabilizing RNA structure -- Functional implications of RNA/RNA and RNA/protein interactions during protein synthesis.…”
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Assembly of the 30S ribosomal subunit in vitro and in cells

Table of Contents: “…Contents: Bacterial ribosome biogenesis -- The Nomura assembly map -- RNA folding and protein binding -- Single molecule fluorescence -- The basis for cooperative assembly -- Isotope pulse chase experiments -- Protein binding kinetics -- The assembly landscape.…”
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Translocation movement of tRNA and mRNA through the ribosome /

Subjects: “…Protein Biosynthesis. 112340…”
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Chemistry of peptide bond formation

Table of Contents: “…Contents: Fundamental processes during protein synthesis -- Peptidyl transfer catalysis by RNA-rich active site -- Ribosome structure solution provided new insights -- Peptide bond formation and peptide release -- Active site of the ribosome -- Universally conserved nucleotides of the active site -- Affinity tag purification of mutant ribosomes -- Active site mutations and rates of peptidyl transfer -- A-site substrates: tRNA vs. puromycin -- "Uninduced" state of ribosome and P-site substrate -- A-site substrates-induced conformational changes -- Peptide release activity of variant ribosomes -- RF catalysis in the large subunit -- RF conserved amino acids in bacteria -- Consequences of RF1 site-directed mutations -- Nucleophile partitioning -- Mutants that lost water specificity -- RF components functioning in activating hydrolysis -- Regulation of translation post-initiation.…”
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The structure of the intact ribosome and ribosomal subunit interactions

Subjects: “…Protein Biosynthesis. 112430…”
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Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G

Subjects: “…Protein Biosynthesis. 112510…”
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Targeting protein kinases for cancer therapy by Matthews, David J. (David John), 1965-

Subjects: “…Protein kinases Inhibitors Therapeutic use.…”
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Analysis of aggregates and particles in protein pharmaceuticals

Table of Contents: “…The critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins -- Separation based analytical methods for measuring protein aggregation -- Laser light scattering-based techniques used for the characterization of protein therapeutics -- Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals -- Analytical methods to measure sub-visible particulates -- Detection of visible particles in parenteral products -- Characterization of aggregates and particles using emerging techniques -- Ultraviolet absorption spectroscopy -- Fluorescence spectroscopy to characterize protein aggregates and particles -- Infrared spectroscopy to characterize protein aggregates -- Raman microscopy for characterization of particles -- Microscopic methods for particle characterization in protein pharmaceuticals -- Comparison of methods for soluble aggregate detection and size characterization -- Protein purification and its relation to protein aggregation and particles -- Formulation development and its relation to protein aggregation and particles.…”
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Mammalian cell biotechnology in protein production

Subjects: “…Proteins Biotechnology.…”
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Update on production of recombinant therapeutic protein transient gene expression / by Zhu, Jianwei

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Algorithmic and AI methods for protein bioinformatics /

Subjects: “…Proteins Analysis Mathematics.…”
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Three decades of protein phosphorylation and cancer the identification and characterization of the src gene product /

Table of Contents: “…Contents: The avian sarcoma virus genome and its products -- Cellular responses to the viral oncoprotein, Src -- The search for the ASV src gene product -- The RNA genome of avian sarcoma virus -- Searching for Src a function -- Impact of Src protein identification and characterization.…”
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Phosphorylase and the origin of reversible protein phosphorylation

Table of Contents: “…Contents: A historical account of the discovery of reversible protein phosphorylation -- Video clips of the late Edwin Krebs speaking about our early work -- Reversible protein phosphorylation represents one of the most prevalent mechanism by which cellular events are regulated -- Establishment of the first hormonal cascade of successive enzymatic reactions initiated by cAMP.…”
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Protein kinase structure, function and regulation

Table of Contents: “…Contents: Overview of protein kinase structure and function using PKA as a prototype for this enzyme superfamily -- What we have learned from the overall structural kinome -- Comparison of many protein kinases -- Eukaryotic protein kinase regulation -- Elucidation of general rules of architecture -- Illustration of how PKA is regulated by cAMP and how it is localized to specific macromolecular complexes through scaffold proteins.…”
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