Search Results - "proteins"

Nuclear protein quality control degradation

Table of Contents: “…Contents: Ubiquitin-mediated degradation of misfolded proteins in the nucleus -- Protein aggregation in the nucleus -- Toxicity of protein aggregates.…”
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Nuclear protein quality control degradation

Table of Contents: “…Contents: Ubiquitin-mediated degradation of misfolded proteins in the nucleus -- Protein aggregation in the nucleus -- Toxicity of protein aggregates.…”
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Self-Assembled Molecules – New Kind of Protein Ligands Supramolecular Ligands /

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Simulating protein folding with full atomistic detail

Table of Contents: “…Contents: Protein folding and disease -- Folding kinetics can have a biological impact -- Why use physical simulation? …”
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Simulating protein folding with full atomistic detail

Table of Contents: “…Contents: Protein folding and disease -- Folding kinetics can have a biological impact -- Why use physical simulation? …”
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Data management of protein interaction networks by Cannataro, Mario, 1964-

Subjects: “…Protein-protein interactions Information resources.…”
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Genetic disorders of carbonic anhydrases II and IV

Table of Contents: “…Contents: Carbonic anhydrase deficiencies -- History of the disease -- Roles of CA II and IV in disease -- Sulfonamide inhibitors for treatment of some disorders -- Characterization of CA isozymes -- CA IV discovery and function -- Mouse knockout models of CA deficiencies -- CA IV, unfolded protein response and retinitis pigmentosa -- ER stress and apoptosis in the choriocapillaris -- Chemical chaperones and treatment of retinitis pigmentosa -- Future studies.…”
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Serpins and the serpinopathies

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The structure-based mechanism of translation initiation in bacteria and eukaryotes

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Structure-based drug design targeting infectious disease

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Modifications of pyruvate handling in health and disease

Subjects: “…Protein Conformation. 111017…”
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Introduction to the ribosome overview of protein synthesis on the ribosome /

Table of Contents: “…Contents: The understanding of heredity and translation of proteins based on the genetic information -- Intensive structural studies of ribosomes, tRNAs and translation factors -- A historical overview -- Main components of translation.…”
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Antibiotic inhibition of ribosome function

Subjects: “…Protein Biosynthesis. 111861…”
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The structural basis for how the large ribosomal subunit catalyses peptide bond formation

Table of Contents: “…Contents: Overview of protein synthesis by the ribosome -- Nature of the polypeptide exit tunnel in the large subunit -- The ribosome is a ribozyme -- Substrate induced fit at the peptidyl transferase center -- Proton shuttle mechanism and transition state stabilization -- Substrate interactions at the large subunit E-site -- Movie of the peptidyl transferase reaction.…”
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Antibiotics that target the 50S ribosomal subunit resistance and other considerations /

Table of Contents: “…-- Analysis of antibacterial market -- Mechanisms of drug resistance -- Sequestration -- How do antibiotics gain entry into cells -- Porins -- Lack of uptake -- Self-promoted uptake drug modification -- Target modifications -- Drug efflux -- Major superfamilies of transport proteins.…”
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High resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions /

Table of Contents: “…Contents: X-ray crystallography -- Protein synthesis -- High resolution structure of ribosomal subunits -- RNA motifs and interactions -- RNA protein interactions -- Metal ions stabilizing RNA structure -- Functional implications of RNA/RNA and RNA/protein interactions during protein synthesis.…”
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Assembly of the 30S ribosomal subunit in vitro and in cells

Table of Contents: “…Contents: Bacterial ribosome biogenesis -- The Nomura assembly map -- RNA folding and protein binding -- Single molecule fluorescence -- The basis for cooperative assembly -- Isotope pulse chase experiments -- Protein binding kinetics -- The assembly landscape.…”
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Translocation movement of tRNA and mRNA through the ribosome /

Subjects: “…Protein Biosynthesis. 112340…”
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Chemistry of peptide bond formation

Table of Contents: “…Contents: Fundamental processes during protein synthesis -- Peptidyl transfer catalysis by RNA-rich active site -- Ribosome structure solution provided new insights -- Peptide bond formation and peptide release -- Active site of the ribosome -- Universally conserved nucleotides of the active site -- Affinity tag purification of mutant ribosomes -- Active site mutations and rates of peptidyl transfer -- A-site substrates: tRNA vs. puromycin -- "Uninduced" state of ribosome and P-site substrate -- A-site substrates-induced conformational changes -- Peptide release activity of variant ribosomes -- RF catalysis in the large subunit -- RF conserved amino acids in bacteria -- Consequences of RF1 site-directed mutations -- Nucleophile partitioning -- Mutants that lost water specificity -- RF components functioning in activating hydrolysis -- Regulation of translation post-initiation.…”
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The structure of the intact ribosome and ribosomal subunit interactions

Subjects: “…Protein Biosynthesis. 112430…”
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