Search Results - "proteins"

GPI-anchored glycoproteins

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The role of MAPT (Tau) in neurodegenerative disease one bullet with many triggers /

Table of Contents: “…Contents: Medical importance of tauopathies -- Microtubule Associated Protein Tau (MAPT) is incorporated into neurofibrillary lesions -- Mutations in the MAPT gene give rise to Frontotemporal dementia with parkinsonism (FTDP-17) -- Common variability in the MAPT, the so-called H1/H1 haplotype and sporadic tauopathies -- Progressive supranuclear Palsy and Cortico-basal degeneration -- Constitutive and conditional transgenic mouse models of tauopathy -- The JNPL3 mouse model of tauopathy -- Neurofibrillary tau pathology in the JNPL3 mice -- A-beta and MAPT pathologies can interact during the development of Alzheimer's disease -- Conditional rTg4510 model of tauopathy -- Major mechanism of neurodegeneration in tauopathy -- Potential therapeutic applications.…”
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Self-perpetuating structural states in biology, disease, and genetics

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Soy protein and formulated meat products by Hoogenkamp, Henk W.

Table of Contents: “…The soy journey -- Soy protein essentials -- Soy protein paradigms and dynamics -- A long and winding road, a history of meat processing -- Lifestyle foods paradigms -- Downsizing super-sized food -- Genetically modified organisms (GMO) -- Functional non-meat protein properties -- Emulsified meats -- Meat patties -- Ingredients for whole muscle meats -- Breaded poultry foods -- Dry fermented sausage -- Liver sausage and patés -- Protein-enhanced fresh meat.…”
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The ubiquitin-proteasome proteolytic system from classical biochemistry to human diseases /

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Structural insights into decoding of mRNA by the ribosome

Subjects: “…Protein Biosynthesis.…”
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Protein degradation and defense against neurodegenerative disease part 1 of 2 /

Table of Contents: “…Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies.…”
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Roles for Hsp40 molecular chaperones in protein misfolding disease

Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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The ERAD network

Table of Contents: “…Contents: Eukaryotic secretory pathway -- ER processes -- ERAD steps -- Substrate recognition -- Glycans as sorting signals -- Yeast ERAD process -- Mammalian ERAD process -- ERAD adapter proteins -- ERAD translocons -- ERAD E3 ligases.…”
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The ERAD network

Table of Contents: “…Contents: Eukaryotic secretory pathway -- ER processes -- ERAD steps -- Substrate recognition -- Glycans as sorting signals -- Yeast ERAD process -- Mammalian ERAD process -- ERAD adapter proteins -- ERAD translocons -- ERAD E3 ligases.…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Human heat shock protein families

Table of Contents: “…Contents: Heat shock proteins -- Regulation and chaperone activity -- Several protein families with many different members -- DNAJ family -- Regulation of differentiation of HSP machines to drive client specificity and differential client processing -- Involvement in folding, proteasomal degradation, autophagy -- Potent suppressors of protein deposit diseases, e.g. …”
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Human heat shock protein families

Table of Contents: “…Contents: Heat shock proteins -- Regulation and chaperone activity -- Several protein families with many different members -- DNAJ family -- Regulation of differentiation of HSP machines to drive client specificity and differential client processing -- Involvement in folding, proteasomal degradation, autophagy -- Potent suppressors of protein deposit diseases, e.g. …”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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Ubiquitin dependent degradation of proteins modified by oxidation, deamidation and glycation role in vision

Table of Contents: “…Contents: Description of cataract and AMD as the ultimate protein misfolding diseases -- Lens development: a model for aging research -- Photo-oxidative stress to the retina -- Etiology -- Environmental factors -- Pathophysiology -- Protein quality control -- Ubiquitin pathway selectivity for oxidatively modified, glutathiolated, deamindated and glycated substrates -- Clinical relevance.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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Ubiquitin dependent degradation of proteins modified by oxidation, deamidation and glycation role in vision

Table of Contents: “…Contents: Description of cataract and AMD as the ultimate protein misfolding diseases -- Lens development: a model for aging research -- Photo-oxidative stress to the retina -- Etiology -- Environmental factors -- Pathophysiology -- Protein quality control -- Ubiquitin pathway selectivity for oxidatively modified, glutathiolated, deamindated and glycated substrates -- Clinical relevance.…”
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Ubiquitin dependent degradation of proteins modified by oxidation, deamidation and glycation role in vision

Table of Contents: “…Contents: Description of cataract and AMD as the ultimate protein misfolding diseases -- Lens development: a model for aging research -- Photo-oxidative stress to the retina -- Etiology -- Environmental factors -- Pathophysiology -- Protein quality control -- Ubiquitin pathway selectivity for oxidatively modified, glutathiolated, deamindated and glycated substrates -- Clinical relevance.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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Promoting non-animal protein sources in sub-Saharan Africa an interdisciplinary study /

Subjects: “…Plant proteins as food Africa, Sub-Saharan.…”
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