Search Results - "proteins"

The sequence determinants of amyloid fibril formation

Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
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The role of immunoglobulin superfamily domains in interactions of immune cells

Table of Contents: “…Contents: Immunoglobulin superfamily (IgSF) domains -- Leukocytes -- Immunoglobulin structure -- Leukocyte membrane proteins -- Cell-surface protein interactions -- Shape and size of membrane proteins -- Rapid evolution of membrane proteins.…”
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The role of immunoglobulin superfamily domains in interactions of immune cells

Table of Contents: “…Contents: Immunoglobulin superfamily (IgSF) domains -- Leukocytes -- Immunoglobulin structure -- Leukocyte membrane proteins -- Cell-surface protein interactions -- Shape and size of membrane proteins -- Rapid evolution of membrane proteins.…”
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GPCR molecular pharmacology and drug targeting shifting paradigms and new directions /

Subjects: “…G proteins.…”
An electronic book accessible through the World Wide Web; click to view

Advancing theory for kinetics and dynamics of complex, many-dimensional systems clusters and proteins /

Subjects: An electronic book accessible through the World Wide Web; click to view

Production of plasma proteins for therapeutic use

Table of Contents: “…Introduction to plasma fractionation -- section 2. Plasma proteins for therapeutic use -- section 3. Pathogen safety of plasma products -- section 4. …”
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Liquid chromatography

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Tumor suppressors

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The pRB/E2F pathway

Table of Contents: “…Contents: The E2F transcription factors control cell cycle entry -- The pRB/E2F pathway -- pRB and E2F are both families of proteins -- Differential roles of the pocket proteins -- Repression and activation of E2F target genes is regulated by distinct E2F complexes -- Rb mutant mice -- Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity -- The activating E2Fs can also induce apoptosis and senescence genes in tumor cells -- Role of pRB-E2F in DNA damage response -- pRB contributes to the activation of pro-apoptotic genes in response to DNA damage.…”
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The glutamate receptors

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The pRB/E2F pathway

Table of Contents: “…Contents: The E2F transcription factors control cell cycle entry -- The pRB/E2F pathway -- pRB and E2F are both families of proteins -- Differential roles of the pocket proteins -- Repression and activation of E2F target genes is regulated by distinct E2F complexes -- Rb mutant mice -- Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity -- The activating E2Fs can also induce apoptosis and senescence genes in tumor cells -- Role of pRB-E2F in DNA damage response -- pRB contributes to the activation of pro-apoptotic genes in response to DNA damage.…”
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RAS and RAF signaling in melanoma biology and therapies /

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Protein folding and dynamics from single molecule spectroscopy

Table of Contents: “…Contents: Concepts in protein folding -- Why study single molecules? -- Development of single molecule methods -- Forster Resonance Energy Transfer (FRET) -- Observing Protein Folding with FRET -- Two-colour confocal fluorescence detection -- The spectroscopic ruler -- End-to-end distance distributions -- Dynamics and averaging regimes -- Equilibrium collapse of an unfolded protein -- Single molecule protein folding kinetics -- Estimating free energy barriers for folding -- Two-state folding of individual protein molecules.…”
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Chaperone mechanisms in cellular protein folding

Table of Contents: “…Contents: The effect of protein aggregation on productive protein folding -- The function of GroEL and GroES as a folding cage for proteins -- Changes in energy landscape within the folding cage -- Cooperation of different chaperone systems in folding pathways: Hsp70 and chaperonins -- Binding of the Hsp70 homologue protein, DnaK, to newly-synthesized polypeptides -- The role of chaperone mechanisms in toxicity suppression of misfolded disease causing proteins -- Potential uses of the chaperone mechanisms in disease therapeutics.…”
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Protein aggregation, metals and oxidative stress in neurodegenerative diseases

Table of Contents: “…Contents: Introduction to protein conformational brain diseases -- Alzheimer's disease, A-beta and tau -- A-beta oligomers and toxicity -- A-beta generates hydrogen peroxide -- Results from experiments using electron spin resonance spectroscopy -- Parkinson's disease -- Generation of hydrogen peroxide from alpha synuclein, toxic fragments of the prion protein and the familial British dementia peptide -- Early oligomers appear to generate hydrogen peroxide -- Huntington's disease -- Protein aggregates could be protective -- Potential common toxic pathway for these brain diseases.…”
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Chaperone mechanisms in cellular protein folding

Table of Contents: “…Contents: The effect of protein aggregation on productive protein folding -- The function of GroEL and GroES as a folding cage for proteins -- Changes in energy landscape within the folding cage -- Cooperation of different chaperone systems in folding pathways: Hsp70 and chaperonins -- Binding of the Hsp70 homologue protein, DnaK, to newly-synthesized polypeptides -- The role of chaperone mechanisms in toxicity suppression of misfolded disease causing proteins -- Potential uses of the chaperone mechanisms in disease therapeutics.…”
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Series (Molecular chaperones)
Series (Protein folding)

Protein aggregation, metals and oxidative stress in neurodegenerative diseases

Table of Contents: “…Contents: Introduction to protein conformational brain diseases -- Alzheimer's disease, A-beta and tau -- A-beta oligomers and toxicity -- A-beta generates hydrogen peroxide -- Results from experiments using electron spin resonance spectroscopy -- Parkinson's disease -- Generation of hydrogen peroxide from alpha synuclein, toxic fragments of the prion protein and the familial British dementia peptide -- Early oligomers appear to generate hydrogen peroxide -- Huntington's disease -- Protein aggregates could be protective -- Potential common toxic pathway for these brain diseases.…”
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Fibrinogen and factor XIII

Table of Contents: “…Contents: Fibrinogen and factor XIII -- Structure -- Biosynthesis -- Fibrin polymerization -- Crosslinking -- Clot mechanical properties -- Interactions with other proteins -- Fibrinolysis -- Platelet aggregation -- Dysfibrinogenemias and variants -- Evolution.…”
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Cathepsin K in bone and joint diseases

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Regulation of blood coagulation by the serpin, antithrombin

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