Search Results - "proteins"

The structural basis for how the large ribosomal subunit catalyses peptide bond formation

Table of Contents: “…Contents: Overview of protein synthesis by the ribosome -- Nature of the polypeptide exit tunnel in the large subunit -- The ribosome is a ribozyme -- Substrate induced fit at the peptidyl transferase center -- Proton shuttle mechanism and transition state stabilization -- Substrate interactions at the large subunit E-site -- Movie of the peptidyl transferase reaction.…”
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Antibiotics that target the 50S ribosomal subunit resistance and other considerations /

Table of Contents: “…-- Analysis of antibacterial market -- Mechanisms of drug resistance -- Sequestration -- How do antibiotics gain entry into cells -- Porins -- Lack of uptake -- Self-promoted uptake drug modification -- Target modifications -- Drug efflux -- Major superfamilies of transport proteins.…”
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High resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions /

Table of Contents: “…Contents: X-ray crystallography -- Protein synthesis -- High resolution structure of ribosomal subunits -- RNA motifs and interactions -- RNA protein interactions -- Metal ions stabilizing RNA structure -- Functional implications of RNA/RNA and RNA/protein interactions during protein synthesis.…”
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Assembly of the 30S ribosomal subunit in vitro and in cells

Table of Contents: “…Contents: Bacterial ribosome biogenesis -- The Nomura assembly map -- RNA folding and protein binding -- Single molecule fluorescence -- The basis for cooperative assembly -- Isotope pulse chase experiments -- Protein binding kinetics -- The assembly landscape.…”
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Translocation movement of tRNA and mRNA through the ribosome /

Subjects: “…Protein Biosynthesis.…”
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Chemistry of peptide bond formation

Table of Contents: “…Contents: Fundamental processes during protein synthesis -- Peptidyl transfer catalysis by RNA-rich active site -- Ribosome structure solution provided new insights -- Peptide bond formation and peptide release -- Active site of the ribosome -- Universally conserved nucleotides of the active site -- Affinity tag purification of mutant ribosomes -- Active site mutations and rates of peptidyl transfer -- A-site substrates: tRNA vs. puromycin -- "Uninduced" state of ribosome and P-site substrate -- A-site substrates-induced conformational changes -- Peptide release activity of variant ribosomes -- RF catalysis in the large subunit -- RF conserved amino acids in bacteria -- Consequences of RF1 site-directed mutations -- Nucleophile partitioning -- Mutants that lost water specificity -- RF components functioning in activating hydrolysis -- Regulation of translation post-initiation.…”
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Factor independent initiation of protein synthesis by IRES RNAs

Subjects: “…Protein Biosynthesis.…”
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The structure of the intact ribosome and ribosomal subunit interactions

Subjects: “…Protein Biosynthesis.…”
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Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G

Subjects: “…Protein Biosynthesis.…”
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Mechanism of translocon function current insights and models /

Table of Contents: “…Contents: Bacterial protein sorting -- Evolutionary conserved translocons -- Structure of SecYEG complex -- Oligomeric assemblies of the SecYEG complex -- Oligomeric state of the active SecYEG complex -- Orientation of the SecYEG in dimeric complexes -- Active or passive role of ribosome and SecA during channel opening.…”
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Metachromatic leukodystrophy

Subjects: “…Protein Conformation. 110308…”
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Glucose-6-Phosphate dehydrogenase deficiency

Table of Contents: “…Contents: G6PD and X-chromosome -- Genetics -- Protein structure and function -- G6PD and neutrophil function/inflammation -- Role of G6PD in diabetes mellitus -- Hypertension -- G6PD modulates vascular oxidant stress -- Angiogenesis is regulated by G6PD activity -- G6PD and vascular reactivity -- G6PD, cardiomyocytes and ischemia-reperfusion.…”
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Pleiotropic and epistatic genes in sickle cell anemia

Subjects: “…Protein Conformation. 110482…”
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Metachromatic leukodystrophy

Subjects: “…Protein Conformation. 110308…”
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Glucose-6-Phosphate dehydrogenase deficiency

Table of Contents: “…Contents: G6PD and X-chromosome -- Genetics -- Protein structure and function -- G6PD and neutrophil function/inflammation -- Role of G6PD in diabetes mellitus -- Hypertension -- G6PD modulates vascular oxidant stress -- Angiogenesis is regulated by G6PD activity -- G6PD and vascular reactivity -- G6PD, cardiomyocytes and ischemia-reperfusion.…”
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Pleiotropic and epistatic genes in sickle cell anemia

Subjects: “…Protein Conformation. 110482…”
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Maintaining the silenced state of master regulatory genes during development

Subjects: “…Chromosomal proteins.…”
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Mechanism of translocon function current insights and models /

Table of Contents: “…Contents: Bacterial protein sorting -- Evolutionary conserved translocons -- Structure of SecYEG complex -- Oligomeric assemblies of the SecYEG complex -- Oligomeric state of the active SecYEG complex -- Orientation of the SecYEG in dimeric complexes -- Active or passive role of ribosome and SecA during channel opening.…”
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Mechanism of translocon function current insights and models /

Table of Contents: “…Contents: Bacterial protein sorting -- Evolutionary conserved translocons -- Structure of SecYEG complex -- Oligomeric assemblies of the SecYEG complex -- Oligomeric state of the active SecYEG complex -- Orientation of the SecYEG in dimeric complexes -- Active or passive role of ribosome and SecA during channel opening.…”
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The sequence determinants of amyloid fibril formation

Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
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