Search Results - "proteins"

Mechanisms of protein folding reactions

Table of Contents: “…Contents: History of protein folding -- Origin of complexity in protein folding kinetics -- Slow reactions coupled to folding -- Prolyl isomerization -- Non-prolyl isomerization -- Association reactions -- Detection of folding intermediates -- Discrimination between different kinetic mechanisms -- Folding of multi-domain proteins.…”
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Kinetic analysis of protein activity

Table of Contents: “…Contents: Thermodynamics vs. kinetics -- Enzyme catalysis -- Conventional and rapid kinetic methods -- Equilibrium and steady-state approaches -- The phases of an enzymatic reaction -- Graphical and statistical analysis -- Enzyme inhibition -- The importance of kinetics for protein activity.…”
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G-protein coupled receptors hormone membrane receptors /

Table of Contents: “…Contents: Rhodopsin: prototype GPCR -- Major classes of GPCRs: rhodopsin-like, glucagon-like, mGlu-like -- Experimental approaches to study GPCR structure -- Rhodopsin crystal structure -- GPCR activation -- Signal trafficking -- Receptor RNA processing/isoforms -- GRKs/arrestin -- Rhodopsin dimerization -- RAMPs: receptor activity modifying protein -- RAMPs, heterodimers and expression -- GPCRs and disease -- Thyroxine and thyrotropin…”
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Yeast prions and protein chaperones a help or a hindrance? /

Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
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Polydactyl zinc finger proteins software and hardware for genomes /

Table of Contents: “…Contents: Development of a universal system for gene regulation -- A diversity of recognition domains -- Phage display -- Targeted endogenous gene regulation in cells and organisms -- The specificity issue and genome size -- Genomic specificity requires polydactyl proteins -- Transcription factor libraries: a powerful new strategy -- Cutting and pasting genes and genomes -- Zinc finger enzymes and designer epigenetic modifications -- Zinc finger nucleases: scissors for genome surgery -- Recombinases -- Gene delivery vehicles.…”
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AMP-activated protein kinase regulating cellular and whole body energy balance /

Table of Contents: “…Contents: AMPK-activated protein kinase -- Role as a cellular energy sensor -- Role in lower eukaryotes -- Metabolic pathways targeted by AMPK -- Cytokines, drugs (including metformin) and xenobiotics that target AMPK -- Identification of upstream kinases -- Regulation by AMP, ATP and calcium ions -- Potential of AMPK as a drug target in cancer…”
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Structure and mechanisms of protein phosphatases

Table of Contents: “…Contents: Reversible protein phosphorylation -- Classification of protein phosphatases -- Protein tyrosine phosphatase family, structure of PTP1B, catalytic mechanism, basis for pTyr specificity, recognition of IRK, regulation by ROS and cyclic sulphenamide -- Dual specificity phosphatases -- Eya protein tyrosine phosphatases -- PPP family of Ser/Thr phosphatases, structure of PP1, catalytic mechanism, inhibition by okadaic acid and microcystin, targeting subunits, PP2A, PP2B, PP5 -- PPM family of Ser/Thr phosphatases, structure, catalytic mechanism -- Summary.…”
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Chaperonin-mediated protein folding part 1 /

Table of Contents: “…Contents: Chaperonin-mediated protein folding by GroEL/GroES -- Folding of newly-translated protein -- Currently known Molecular chaperones (including the Heat shock protein Hsp group) -- Recognition of non native proteins by Hsps and formation of aggregates -- Aggregates and neurodegenerative disease -The discovery of the chaperonin-mediated folding -- The structure of the GroES/GroeEL chaperonin class of molecular chaperones -- The steps of polypeptide binding and folding -- The action of ATP binding and hydrolysis in driving the rings of the machine through cycles of binding and release cycle.…”
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Chaperonin-mediated protein folding part 2 /

Table of Contents: “…Contents: Chaperonin-mediated protein folding by GroEL/GroES -- Folding of newly-translated protein -- Currently known Molecular chaperones (including the Heat shock protein Hsp group) -- Recognition of non native proteins by Hsps and formation of aggregates -- Aggregates and neurodegenerative disease -The discovery of the chaperonin-mediated folding -- The structure of the GroES/GroeEL chaperonin class of molecular chaperones -- The steps of polypeptide binding and folding -- The action of ATP binding and hydrolysis in driving the rings of the machine through cycles of binding and release cycle.…”
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Protein homeostasis during ageing

Table of Contents: “…Contents: Ageing and senescent decline -- Protein modifications during ageing -- Main cellular protein homeostasis mechanisms -- Effects of ageing on protein homeostasis -- Regulation of protein synthesis -- Linking protein synthesis and ageing.…”
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Mechanical and dynamical principles of protein nanomotors the key to nano-engineering applications / by Khataee, A. R. (Ali Reza), 1977-

Subjects: “…Protein engineering.…”
An electronic book accessible through the World Wide Web; click to view

Protein homeostasis and the chaperone interaction network in Arabidopsis thaliana

Table of Contents: “…Contents: Plant cellular protein quality control systems -- Arabidopsis regulated protein degradation by the proteasome -- Plant stress resistance -- Mechanism of action of molecular chaperones -- Molecular chaperones in Arabidopsis -- Chaperone interaction networks in Arabidopsis.…”
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Human heat shock protein families

Table of Contents: “…Contents: Heat shock proteins -- Regulation and chaperone activity -- Several protein families with many different members -- DNAJ family -- Regulation of differentiation of HSP machines to drive client specificity and differential client processing -- Involvement in folding, proteasomal degradation, autophagy -- Potent suppressors of protein deposit diseases, e.g. …”
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The ERAD network

Table of Contents: “…Contents: Eukaryotic secretory pathway -- ER processes -- ERAD steps -- Substrate recognition -- Glycans as sorting signals -- Yeast ERAD process -- Mammalian ERAD process -- ERAD adapter proteins -- ERAD translocons -- ERAD E3 ligases.…”
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Biogenesis of cellular iron-sulfur proteins part II, the essential role of mitochondria and the CIA machinery /

Table of Contents: “…Contents: Cytosolic and nuclear Fe/S proteins maturation -- Role of mitochondria in cytosolic and nuclear Fe/S protein biogenesis -- Functions of proteins involved in Fe/S protein biogenesis -- Importance of Fe/S protein biogenesis for genome maintenance.…”
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Designing proteins with life sustaining activities part 2 of 2 /

Table of Contents: “…Contents: Novel designed proteins: mechanism of action -- Function rescue experiments using novel proteins -- Evolving novel proteins (generalists vs. specialists) -- Towards artificial proteomes capable of sustaining life.…”
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Design and engineering of zinc-finger domains

Table of Contents: “…Contents: Introduction to zinc finger domains -- Designer zinc-fingers: de novo design and engineering -- Zinc-fingers and DNA binding -- Designer zinc-fingers: DNA-binders -- polydactyl approach -- Designer zinc-fingers: protein-binders.…”
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Design and engineering of zinc-finger domains

Table of Contents: “…Contents: Introduction to zinc finger domains -- Designer zinc-fingers: de novo design and engineering -- Zinc-fingers and DNA binding -- Designer zinc-fingers: DNA-binders -- polydactyl approach -- Designer zinc-fingers: protein-binders.…”
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Simulating protein folding with full atomistic detail

Table of Contents: “…Contents: Protein folding and disease -- Folding kinetics can have a biological impact -- Why use physical simulation? …”
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Oxidation of amino acids, peptides, and proteins kinetics and mechanism / by Sharma, Virender K.

Subjects: An electronic book accessible through the World Wide Web; click to view