Search Results - "proteins"

Fast folding dynamics of small proteins placing limits on diffusional limits /

Table of Contents: “…Contents: Basic time scales and diffusional limits in protein folding -- Applying reaction rate theories to folding -- Kramers behavior and friction -- Internal friction of polymer chains -- Evidence for (or against) internal friction in protein folding -- Fast folding experiments and methodology -- Interpretations: internal time scales versus internal viscosity -- Limitations of the "diffusional limits" picture.…”
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Molecular dynamics simulations of protein dynamics, unfolding and misfolding

Table of Contents: “…Contents: Molecular mechanics force fields and starting structures -- Molecular dynamics (MD) simulations -- Native protein dynamics -- Protein unfolding -- Unfolding pathways of En-HD -- Protein unfolding and disease -- Objectives for MD simulations.…”
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Basic studies of protein folding and stability the folding of related protein families /

Table of Contents: “…Contents: The basics of protein folding studies: protein stability (thermodynamics) and protein folding kinetics -- The shape and interpretation of simple chevron plots -- How protein engineering phi value analysis can be used to investigate the structure of the transition state for protein folding -- How studies of the folding of related proteins can simplify the problem of investigating how proteins fold -- Comparison of the folding of complex, all-beta immunoglobulin-like proteins to the folding of simple 3-helix bundles.…”
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Fundamentals and principles for engineering proteolytic activity

Table of Contents: “…Contents: Protein engineering goals -- Applications of engineered proteins -- Strategies for engineering proteins -- Specific examples of redesigned proteases to understand structure/function relationships -- Engineered catalysis and molecular recognition in proteases.…”
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G-protein coupled receptors essential methods /

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Protein degradation in health and disease

Subjects: “…Proteins Metabolism Congresses.…”
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Hemolymph proteins and functional peptides recent advances in insects and other arthropods. Volume 1 /

“…Hemolymph proteins and functional peptides : recent advances in insects and other arthropods,…”
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Protein kinase CK2

Subjects: “…Protein kinase CK2.…”
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Applied food protein chemistry /

Subjects: “…Proteins in human nutrition.…”
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Neuronal calcium sensor proteins calcium sensors and regulators of diverse cellular functions /

Table of Contents: “…Contents: Introduction to calcium sensors -- The neuronal calcium sensor (NCS) protein family -- The calcium/myristoyl switch -- Dynamics of hippocalcin translocation -- Specific localization of NCS proteins -- Functions of NCS-1 -- Hippocalcin in synaptic plasticity -- KChIP proteins in traffic of potassium channels -- Molecular targets of NCS proteins -- The unique features of the NCS family.…”
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Protein homeostasis during ageing

Table of Contents: “…Contents: Ageing and senescent decline -- Protein modifications during ageing -- Main cellular protein homeostasis mechanisms -- Effects of ageing on protein homeostasis -- Regulation of protein synthesis -- Linking protein synthesis and ageing.…”
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Chaperonin-mediated protein folding part 1 /

Table of Contents: “…Contents: Chaperonin-mediated protein folding by GroEL/GroES -- Folding of newly-translated protein -- Currently known Molecular chaperones (including the Heat shock protein Hsp group) -- Recognition of non native proteins by Hsps and formation of aggregates -- Aggregates and neurodegenerative disease -The discovery of the chaperonin-mediated folding -- The structure of the GroES/GroeEL chaperonin class of molecular chaperones -- The steps of polypeptide binding and folding -- The action of ATP binding and hydrolysis in driving the rings of the machine through cycles of binding and release cycle.…”
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Chaperonin-mediated protein folding part 2 /

Table of Contents: “…Contents: Chaperonin-mediated protein folding by GroEL/GroES -- Folding of newly-translated protein -- Currently known Molecular chaperones (including the Heat shock protein Hsp group) -- Recognition of non native proteins by Hsps and formation of aggregates -- Aggregates and neurodegenerative disease -The discovery of the chaperonin-mediated folding -- The structure of the GroES/GroeEL chaperonin class of molecular chaperones -- The steps of polypeptide binding and folding -- The action of ATP binding and hydrolysis in driving the rings of the machine through cycles of binding and release cycle.…”
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AMP-activated protein kinase regulating cellular and whole body energy balance /

Table of Contents: “…Contents: AMPK-activated protein kinase -- Role as a cellular energy sensor -- Role in lower eukaryotes -- Metabolic pathways targeted by AMPK -- Cytokines, drugs (including metformin) and xenobiotics that target AMPK -- Identification of upstream kinases -- Regulation by AMP, ATP and calcium ions -- Potential of AMPK as a drug target in cancer…”
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Structure and mechanisms of protein phosphatases

Table of Contents: “…Contents: Reversible protein phosphorylation -- Classification of protein phosphatases -- Protein tyrosine phosphatase family, structure of PTP1B, catalytic mechanism, basis for pTyr specificity, recognition of IRK, regulation by ROS and cyclic sulphenamide -- Dual specificity phosphatases -- Eya protein tyrosine phosphatases -- PPP family of Ser/Thr phosphatases, structure of PP1, catalytic mechanism, inhibition by okadaic acid and microcystin, targeting subunits, PP2A, PP2B, PP5 -- PPM family of Ser/Thr phosphatases, structure, catalytic mechanism -- Summary.…”
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Protein folding inside the cell macromolecular crowding and protein aggregation /

Table of Contents: “…Contents: The principle of protein self-assembly -- Discovery of proteins binding to newly synthesized polypeptides -- Discovery of the chaperonins -- Origins of the molecular chaperone concept -- Replacement of spontaneous self-assembly by assisted self-assembly -- Protein aggregation as a universal cellular problem -- Macromolecular crowding and its effects on reaction rates and association constants -- Stimulation of aggregation by crowding -- How chaperones combat aggregation -- Definition of molecular chaperones -- The chaperone function.…”
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Kinetic analysis of protein activity

Table of Contents: “…Contents: Thermodynamics vs. kinetics -- Enzyme catalysis -- Conventional and rapid kinetic methods -- Equilibrium and steady-state approaches -- The phases of an enzymatic reaction -- Graphical and statistical analysis -- Enzyme inhibition -- The importance of kinetics for protein activity.…”
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G-protein coupled receptors hormone membrane receptors /

Table of Contents: “…Contents: Rhodopsin: prototype GPCR -- Major classes of GPCRs: rhodopsin-like, glucagon-like, mGlu-like -- Experimental approaches to study GPCR structure -- Rhodopsin crystal structure -- GPCR activation -- Signal trafficking -- Receptor RNA processing/isoforms -- GRKs/arrestin -- Rhodopsin dimerization -- RAMPs: receptor activity modifying protein -- RAMPs, heterodimers and expression -- GPCRs and disease -- Thyroxine and thyrotropin…”
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Polydactyl zinc finger proteins software and hardware for genomes /

Table of Contents: “…Contents: Development of a universal system for gene regulation -- A diversity of recognition domains -- Phage display -- Targeted endogenous gene regulation in cells and organisms -- The specificity issue and genome size -- Genomic specificity requires polydactyl proteins -- Transcription factor libraries: a powerful new strategy -- Cutting and pasting genes and genomes -- Zinc finger enzymes and designer epigenetic modifications -- Zinc finger nucleases: scissors for genome surgery -- Recombinases -- Gene delivery vehicles.…”
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Yeast prions and protein chaperones a help or a hindrance? /

Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
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