Search Results - "proteins"

Mapping disordered proteins with single-molecule FRET

Table of Contents: “…Contents: Protein folding and folding landscapes -- Single-molecule FRET -- Protein collapse -- Polymer models to describe protein collapse -- The dynamics of unfolded and intrinsically disordered proteins -- Rouse models -- Internal friction.…”
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Cytoplasmic epigenetics proteins acting as genes /

Table of Contents: “…Contents: Prions (infectious proteins) include several self-propagating amyloids of S. cerevisiae and Podospora anserina and a self-activating enzyme of S. cerevisiae -- these non-chromosomal genetic elements are genes composed of protein, just as nucleic acids can catalyse enzymatic reactions -- the amyloid-based prions [PSI+] and [URE3] are diseases of yeast, but the [Het-s] prion of Podospora carries out a normal function for that organism, heterokaryon incompatibility.…”
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Respiration, reactive oxygen species and uncoupling proteins

Table of Contents: “…Contents: Reactive oxygen species production by mitochondria -- Mitochondrial free radicals and ageing in short-lived and long-lived species -- Topology and sites of ROS production in the electron transport chain -- Regulation of ROS production by mild uncoupling -- Uncoupling of mitochondria by uncoupling proteins -- Superoxide and reactive alkenal activation of UCPs -- A model for UCP activation -- Evidence that UCPs attenuate ROS.…”
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The biogenesis of E. coli inner membrane proteins

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Cytoplasmic epigenetics proteins acting as genes /

Table of Contents: “…Contents: Prions (infectious proteins) include several self-propagating amyloids of S. cerevisiae and Podospora anserina and a self-activating enzyme of S. cerevisiae -- these non-chromosomal genetic elements are genes composed of protein, just as nucleic acids can catalyse enzymatic reactions -- the amyloid-based prions [PSI+] and [URE3] are diseases of yeast, but the [Het-s] prion of Podospora carries out a normal function for that organism, heterokaryon incompatibility.…”
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Respiration, reactive oxygen species and uncoupling proteins

Table of Contents: “…Contents: Reactive oxygen species production by mitochondria -- Mitochondrial free radicals and ageing in short-lived and long-lived species -- Topology and sites of ROS production in the electron transport chain -- Regulation of ROS production by mild uncoupling -- Uncoupling of mitochondria by uncoupling proteins -- Superoxide and reactive alkenal activation of UCPs -- A model for UCP activation -- Evidence that UCPs attenuate ROS.…”
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The biogenesis of E. coli inner membrane proteins

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Mapping disordered proteins with single-molecule FRET

Table of Contents: “…Contents: Protein folding and folding landscapes -- Single-molecule FRET -- Protein collapse -- Polymer models to describe protein collapse -- The dynamics of unfolded and intrinsically disordered proteins -- Rouse models -- Internal friction.…”
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G proteins and the biology of depression and antidepressants

Table of Contents: “…Contents: Depression -- Antidepressant drug targets -- G protein signaling -- GPCR -- Gs alpha lipid raft localization and antidepressant treatment -- Gs alpha Acylation status and lipid raft localization -- Gs alpha palmitoylation status and lipid raft localization -- Blood biomarkers for depression.…”
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Biogenesis of cellular iron-sulfur proteins part 1, structure, function, and assembly in mitochondria /

Table of Contents: “…Contents: Structure and functions of iron-sulfur (Fe/S) clusters and proteins -- Analysis of Fe/S proteins and their biogenesis -- Mechanisms of Fe/S protein assembly in mitochondria -- Mitochondrial "Fe/S diseases."…”
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Biogenesis of cellular iron-sulfur proteins part 1, structure, function, and assembly in mitochondria /

Table of Contents: “…Contents: Structure and functions of iron-sulfur (Fe/S) clusters and proteins -- Analysis of Fe/S proteins and their biogenesis -- Mechanisms of Fe/S protein assembly in mitochondria -- Mitochondrial "Fe/S diseases."…”
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Design and engineering of zinc-finger domains

Table of Contents: “…Contents: Introduction to zinc finger domains -- Designer zinc-fingers: de novo design and engineering -- Zinc-fingers and DNA binding -- Designer zinc-fingers: DNA-binders -- polydactyl approach -- Designer zinc-fingers: protein-binders.…”
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The roles of intrinsic disorder in protein interaction networks

Table of Contents: “…Contents: Introducing the protein intrinsic disorder concept and intrinsically disordered proteins (IDPs) -- Structural peculiarities of IDPs -- Sequence peculiarities of IDPs -- Abundance of IDPs and their functions -- Intrinsic disorder in protein interaction networks -- Peculiarities of disorder-based binding and regulation -- Why are IDPs commonly involved in protein interactions?.…”
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The roles of intrinsic disorder in protein interaction networks

Table of Contents: “…Contents: Introducing the protein intrinsic disorder concept and intrinsically disordered proteins (IDPs) -- Structural peculiarities of IDPs -- Sequence peculiarities of IDPs -- Abundance of IDPs and their functions -- Intrinsic disorder in protein interaction networks -- Peculiarities of disorder-based binding and regulation -- Why are IDPs commonly involved in protein interactions?.…”
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The sequence determinants of amyloid fibril formation

Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
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The protein C-Thrombomodulin mechanism regulating multiple biological systems /

Table of Contents: “…Contents: Protein C and thrombomodulin -- Mechanisms of action in coagulation and inflammation -- Diagnostic and therapeutic insights.…”
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The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription.…”
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Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

Titin 127 a protein with a complex folding landscape /

Table of Contents: “…Contents: Examination of the folding of titin 127 -- Evolution of the protein to withstand stress from mutation, the environment and to withstand mechanical force in the muscle -- Use of a combination of protein engineering, kinetic and thermodynamic measurements, computer simulations and single molecule atomic force microscopy to understand how evolution acts on protein sequences to allow them to adapt to stressful conditions, probably explaining why immunoglobulin-like proteins are used so successfully in evolution to perform a number of functions.…”
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Titin 127 a protein with a complex folding landscape /

Table of Contents: “…Contents: Examination of the folding of titin 127 -- Evolution of the protein to withstand stress from mutation, the environment and to withstand mechanical force in the muscle -- Use of a combination of protein engineering, kinetic and thermodynamic measurements, computer simulations and single molecule atomic force microscopy to understand how evolution acts on protein sequences to allow them to adapt to stressful conditions, probably explaining why immunoglobulin-like proteins are used so successfully in evolution to perform a number of functions.…”
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Metachromatic leukodystrophy

Subjects: “…Protein Conformation.…”
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